PAM binding ensures orientational integration during Cas4-Cas1-Cas2-mediated CRISPR adaptation

1. Download : Download high-res image (190KB)
2. Download : Download full-size image

     

High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation

1. Download : Download high-res image (147KB)
2. Download : Download full-size image

     

Octopamine mediates sugar relief from a chronic-stress-induced depression-like state in Drosophila

1. Download : Download high-res image (167KB)
2. Download : Download full-size image

     

Direct Visualization of Native CRISPR Target Search in Live Bacteria Reveals Cascade DNA Surveillance Mechanism

1. Download : Download high-res image (161KB)
2. Download : Download full-size image

     

DNA topology regulates PAM-Cas9 interaction and DNA unwinding to enable near-PAMless cleavage by thermophilic Cas9

1. Download : Download high-res image (274KB)
2. Download : Download full-size image

     

Multiple adaptations underly co-option of a CRISPR surveillance complex for RNA-guided DNA transposition

1. Download : Download high-res image (212KB)
2. Download : Download full-size image

     

Type IV-A CRISPR-Csf complex: Assembly,dsDNA targeting,and CasDinG recruitment

1. Download : Download high-res image (312KB)
2. Download : Download full-size image

     

The Circadian Clock Gene Circuit Controls Protein and Phosphoprotein Rhythms in Arabidopsis thaliana

1. Download : Download high-res image (116KB)
2. Download : Download full-size image

     

Parinarioidins A-B,unprecedented flavonoids from the bark of Brosimum parinarioides Ducke

1. Download : Download high-res image (450KB)
2. Download : Download full-size image

     

Predicting Successful Generation and Inhibition of Seizure-like Afterdischarges and Mapping Their Seizure Networks Using fMRI

1. Download : Download high-res image (185KB)
2. Download : Download full-size image

     

Opto-katanin,an optogenetic tool for localized,microtubule disassembly

1. Download : Download high-res image (204KB)
2. Download : Download full-size image

     

Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases

1. Download : Download high-res image (218KB)
2. Download : Download full-size image

     

Large-scale genome sequencing reveals the driving forces of viruses in microalgal evolution

1. Download : Download high-res image (277KB)
2. Download : Download full-size image

     

Spatial transcriptional mapping of the human nephrogenic program

1. Download : Download high-res image (216KB)
2. Download : Download full-size image

     

Brain microvasculature has a common topology with local differences in geometry that match metabolic load

1. Download : Download high-res image (230KB)
2. Download : Download full-size image

     

Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding

1. Download : Download high-res image (220KB)
2. Download : Download full-size image

     

Temperature and Sweet Taste Integration in Drosophila

1. Download : Download high-res image (164KB)
2. Download : Download full-size image

     

NAD precursors cycle between host tissues and the gut microbiome

1. Download : Download high-res image (125KB)
2. Download : Download full-size image

     

Cyclic CMP and cyclic UMP mediate bacterial immunity against phages

1. Download : Download high-res image (159KB)
2. Download : Download full-size image

     

Nutritional reprogramming of mouse liver proteome is dampened by metformin,resveratrol, and rapamycin

1. Download : Download high-res image (236KB)
2. Download : Download full-size image