A single chemosensory GPCR is required for a concentration-dependent behavioral switching in C. elegans

1. Download : Download high-res image (109KB)
2. Download : Download full-size image

     

The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes for retrieval from cilia

1. Download : Download high-res image (228KB)
2. Download : Download full-size image

     

Autonomous sensing of the insulin peptide by an olfactory G protein-coupled receptor modulates glucose metabolism

1. Download : Download high-res image (176KB)
2. Download : Download full-size image

     

Evolving cryo-EM structural approaches for GPCR drug discovery

1. Download : Download high-res image (264KB)
2. Download : Download full-size image

     

Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors

1. Download : Download high-res image (247KB)
2. Download : Download full-size image

     

Dual mechanisms of cholesterol-GPCR interactions that depend on membrane phospholipid composition

1. Download : Download high-res image (207KB)
2. Download : Download full-size image

     

The adhesion GPCRs CELSR1–3 and LPHN3 engage G proteins via distinct activation mechanisms

1. Download : Download high-res image (349KB)
2. Download : Download full-size image

     

Molecular insights into the biased signaling mechanism of the μ-opioid receptor

1. Download : Download high-res image (155KB)
2. Download : Download full-size image

     

Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry

1. Download : Download high-res image (159KB)
2. Download : Download full-size image

     

Cholesterol occupies the lipid translocation pathway to block phospholipid scrambling by a G protein-coupled receptor

1. Download : Download high-res image (118KB)
2. Download : Download full-size image

     

Delineating the conformational landscape of the adenosine A2A receptor during G protein coupling

1. Download : Download high-res image (171KB)
2. Download : Download full-size image

     

Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling

1. Download : Download high-res image (150KB)
2. Download : Download full-size image

     

Molecular Insight into Recognition of the CGRPR Complex by Migraine Prevention Therapy Aimovig (Erenumab)

1. Download : Download high-res image (204KB)
2. Download : Download full-size image

     

Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions

1. Download : Download high-res image (221KB)
2. Download : Download full-size image

     

Modulation of adenosine A2a receptor oligomerization by receptor activation and PIP2 interactions

1. Download : Download high-res image (214KB)
2. Download : Download full-size image

     

Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G protein subunits

1. Download : Download high-res image (137KB)
2. Download : Download full-size image

     

Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response

1. Download : Download high-res image (288KB)
2. Download : Download full-size image

     

System-wide mapping of peptide-GPCR interactions in C. elegans

1. Download : Download high-res image (239KB)
2. Download : Download full-size image

     

A sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo

1. Download : Download high-res image (156KB)
2. Download : Download full-size image

     

Functions of Opsins in Drosophila Taste

1. Download : Download high-res image (230KB)
2. Download : Download full-size image