The miniature CRISPR-Cas12m effector binds DNA to block transcription

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Structure of the type V-C CRISPR-Cas effector enzyme

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Structure and engineering of the type III-E CRISPR-Cas7-11 effector complex

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CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank

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Viral recombination systems limit CRISPR-Cas targeting through the generation of escape mutations

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Cleavage of viral DNA by restriction endonucleases stimulates the type II CRISPR-Cas immune response

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Distribution and phasing of sequence motifs that facilitate CRISPR adaptation

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Structure of the miniature type V-F CRISPR-Cas effector enzyme

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DNA topology regulates PAM-Cas9 interaction and DNA unwinding to enable near-PAMless cleavage by thermophilic Cas9

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Structural basis of target DNA recognition by CRISPR-Cas12k for RNA-guided DNA transposition

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A target expression threshold dictates invader defense and prevents autoimmunity by CRISPR-Cas13

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Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools

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Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells

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PAM binding ensures orientational integration during Cas4-Cas1-Cas2-mediated CRISPR adaptation

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Cas9 deactivation with photocleavable guide RNAs

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Cas12n nucleases,early evolutionary intermediates of type V CRISPR,comprise a distinct family of miniature genome editors

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Structural basis for self-cleavage prevention by tag:anti-tag pairing complementarity in type VI Cas13 CRISPR systems

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High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation

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A naturally DNase-free CRISPR-Cas12c enzyme silences gene expression

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Localized EMT reprograms glial progenitors to promote spinal cord repair

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