共查询到20条相似文献,搜索用时 15 毫秒
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
Look GC Vacin C Dias TM Ho S Tran TH Lee LL Wiesner C Fang F Marra A Westmacott D Hromockyj AE Murphy MM Schullek JR 《Bioorganic & medicinal chemistry letters》2004,14(6):1423-1426
Solid-phase synthetic methods for biaryl-based compounds were developed resulting in the construction of two 1000-member libraries. Numerous compounds were identified by high-throughput screening using whole cell screens to exhibit anti-microbial activity against Gram-positive bacteria. A series of biaryl compounds containing natural and unnatural amino acids were made to explore the SAR of the amino acid functionality. 相似文献
13.
14.
15.
16.
17.
18.
19.
Johanna Faist Werner Seebacher Christian Schlapper Marcel Kaiser Reto Brun Robert Saf Robert Weis 《Bioorganic & medicinal chemistry》2009,17(10):3595-3603
Several bicyclic amides and esters of dialkylamino acids were prepared. Their activities against a multiresistant strain of Plasmodium falciparum and against Trypanosoma brucei rhodesiense (STIB 900) were examined. Structure–activity relationships were discussed. Particularly the ester compounds showed good antiplasmodial and antitrypanosomal activity and a single compound was tested in vivo against Plasmodium berghei. 相似文献
20.
Cultures of Lemna paucicostata 6746 were exposed to a single96-hr dark period followed by continuous illumination at 24?1?C.Flowering percentage increased to a maximum 3 days after theend of the dark period and then fell off to 0% on the 5th day.Among 20 amino acids and 2 amides tested, addition of asparagine,aspartate, glutamate, -alanine, glycine and serine clearly increasedthe flowering percentages and retarded the regression of floralbuds by 23 days. These substances given after the endof the long dark period were more effective than those givenduring the dark period, suggesting that they favored the flower-producingprocess following the inductive dark process. On the other hand,if the above amino acids or amide were applied under repeatedlight-dark cycles, they shortened the critical dark period by12 hr and almost completely nullified the light-breakeffect. They seem to promote the flower-inductive dark process,too. Glutamate, for instance, was effective even at 5 µM, whilethis amino acid is found in the plant body in large quantities.The mechanism of flower promotion by these amino acids and amideremains unknown. (Received June 3, 1976; ) 相似文献