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1.
Pregnant women in developing countries are vulnerable to multiple micronutrient deficiencies. Studies assessing serum levels
of the micronutrients and magnitude of their deficiencies are very scarce in African subjects. This study was aimed at determining
serum levels of micronutrients in 375 pregnant (42 HIV seropositive) and 76 non-pregnant women (20 HIV seropositive) who visited
the University of Gondar Hospital, Gondar, Ethiopia. Serum concentrations of zinc,\ copper, selenium, calcium, and magnesium
were determined using an inductively coupled plasma mass spectrometer. Irrespective of HIV serostatus, pregnant women had
significantly higher serum concentrations of copper and copper/zinc ratio and significantly lower magnesium compared to those
in non-pregnant women (P < 0.05). Except for selenium, which was significantly lower in HIV-seropositive pregnant women (P < 0.05), the mean serum concentrations of zinc, copper, calcium, and magnesium were not significantly different between pregnant
women by HIV serostatus. The prevalence of deficiency in zinc, magnesium, selenium, and calcium in the pregnant women, irrespective
of their HIV serostatus, was 66.7%, 25.6%, 21.9%, and 9.3%, respectively. The magnitude of deficiency in zinc, magnesium,
and selenium was significantly higher in HIV seropositive pregnant women (76.2%, 52.4%, and 45.2%) than that in HIV-seronegative
pregnant women (65.5%, 22.2%, and 18.9%) and in HIV-seronegative non-pregnant women (42.9%, 8.1%, and 30.4%; P < 0.05). Deficiency in one, two, three, or four mineral elements was observed in 44.8%, 14.4%, 9.9%, and 5.1% of the pregnant
women, respectively. Only 25.9% of the pregnant women and 44.7% of the non-pregnant women were not deficient in any of the
micronutrients. The high prevalence of micronutrient deficiencies in pregnant and non-pregnant women in Gondar, Ethiopia warrants
the need for strategies on prevention and control of the deficiencies. 相似文献
2.
The combined effects of vitamin E and selenium were studied in native Anatolian horses subject to strenuous exercise. The
concentrations of copper, zinc, iron, calcium, potassium, and magnesium were determined in serum by atomic absorption spectrometry
in two study groups (n = 25 each), one of which served as untreated controls. After exercising the horses by running 1,500 m in about 7 min, only
the copper level and the copper/zinc ratio significantly increased (p < 0.05), but the concentrations of calcium, potassium, iron, and magnesium remained unchanged. In horses treated with vitamin
E and selenium, the calcium and potassium levels decreased to levels lower than those of untreated controls before and after
exercise. The iron levels were not changed by exercise or treatment alone but increased when the horses had been supplemented
and exercised. The copper level and the copper/zinc ration increased as a result of exercise in both treated and untreated
horses. These changes suggest that supplementation with vitamin E and selenium had an important effect on the serum concentrations
of calcium, potassium, copper, iron, and the copper/zinc ratio. 相似文献
3.
Bülbül Hizel S Sanli C Bayar Muluk N Albayrak M Ozyazici A Apan A 《Biological trace element research》2008,124(2):129-134
The aim of this study was to investigate the effects of topotecan, a topoisomerase I-inhibiting anticancer agent, on hematologic
parameters and serum levels of trace elements. The study was conducted on three groups consisting of 16 and 18 rabbits in
the study groups and 15 rabbits in the control group. Rabbits in group I (n = 16) received high-dose topotecan intravenously (i.v.; 0.5 mg/kg once daily), while rabbits in group II (n = 18) received low-dose topotecan i.v. (0.25 mg/kg once daily) for 3 days. The 15 rabbits comprising the control group did
not receive topotecan. Serum samples were collected from each rabbit on the first day, before the treatment, and on the 15th
day of treatment. Erithrocytes, hemoglobin, white blood cell count, thrombocyte count, and trace elements such as selenium,
copper, lead, zinc, and cobalt were analyzed. Hemoglobin levels and erythrocyte counts were lower in both study groups than
in the control group. However, thrombocyte and leukocyte counts were similar in all three groups (p > 0.005). Serum trace element levels (copper, lead, zinc, and cobalt) did not differ significantly between groups. However,
serum selenium levels were significantly lower in both study groups than the control group (p < 0.001). The results revealed that topotecan treatment causes a decrease in erythrocyte counts and hemoglobin levels due
to bone marrow suppression, and these effects must be taken into account during treatment. In addition, selenium supplementation
might be helpful in cancer patients receiving topotecan to increase the effect of the chemotherapeutic agent. 相似文献
4.
Sovik Mondal Sudipto Haldar Pinaki Saha Tapan Kumar Ghosh 《Biological trace element research》2010,137(2):190-205
Supplementation of broiler diets with copper, manganese, and zinc at levels higher than that stipulated by the National Research
Council 1994 reportedly improved live weight, feed conversion, and cured leg abnormality supposedly caused by inadequate intake of Mn
and Zn. The objective of the study was to ascertain the effects of plethoric supplementation of copper (Cu), manganese (Mn),
and zinc (Zn) on performance and metabolic responses in broiler chickens. The study also aimed to discriminate the responses
of the birds when the mineral elements were supplemented either in an inorganic or in an organic form. Cobb 400 broiler chickens
(1-day old, n = 300) were assigned to three dietary treatments each containing nine replicates with ten birds for 39 days. The treatments
included a control in which the diet was devoid of supplemental trace elements and treatments supplemented with an inorganic
trace element premix (ITM) and supplemented with a combination of the inorganic and an organic trace element premix (OTM).
The ITM contained (per kilogram) copper, 15 g; iron, 90 g; manganese, 90 g; zinc, 80 g (all as sulfated salts); iodine (as
potassium iodide), 2 g; and selenium (as sodium selenite), 0.3 g. The OTM on the other hand, contained copper, 2.5 g; iron,
15 g; manganese, 15 g; zinc, 13.33 g; and chromium, 0.226 g (all as protein chelates). Plethoric supplementation of trace
elements improved live weight gain and feed/gain ratio (p < 0.05). Leg abnormality developed in the 16% of the control group of birds but not in the supplemented group. Metabolizability
of dry matter, organic matter, and protein was higher (p < 0.01) in the ITM and OTM groups. Excretion of Cu, Fe, and Zn decreased (p < 0.1) due to supplementation of the trace elements leading to increased apparent absorption of the said mineral elements
(p < 0.01). Concentration of the concerned trace elements in serum, liver, and composite muscle samples was higher (p < 0.05) in the ITM and OTM dietary groups indicating an increased deposition of the said mineral elements due to supplementation.
Although the study revealed subtle difference between the inorganic and organic mineral premixes with regards to the parameters
mentioned above, it became apparent that it is possible to reduce excretion of these trace elements by a judicious escalation
in the level of supplementation. The results of the present investigation further revealed that the trace mineral requirement
of broiler chickens suggested by the National Research Council may not be optimum to support the maximum growth potential
of the high yielding strains, and it is reasonable to consider a review of the current NRC recommendations to meet the needs
of the modern birds. 相似文献
5.
Ayhan Dogukan Nurhan Sahin Mehmet Tuzcu Vijaya Juturu Cemal Orhan Muhittin Onderci James Komorowski Kazim Sahin 《Biological trace element research》2009,131(2):124-132
The present study was conducted to investigate the effects of chromium histidinate (CrHis) against experimentally induced
type II diabetes and on chromium (Cr), zinc (Zn), selenium (Se), manganese (Mn), iron (Fe), and copper (Cu) in serum, liver,
and kidney of diabetic rats. The male Wistar rats (n = 60, 8 weeks old) were divided into four groups. Group I received a standard diet (12% of calories as fat); group II were
fed standard diet and received CrHis (110 mcg CrHis/kg body weight per day); group III received a high-fat diet (HFD; 40% of calories as fat) for 2 weeks and then
were injected with streptozotocin (STZ) on day 14 (STZ, 40 mg/kg i.p.; HFD/STZ); group IV were treated as group III (HFD/STZ)
but supplemented with 110 mcg CrHis/kg body weight per day. The mineral concentrations in the serum and tissue were determined
by atomic absorption spectrometry. Compared to the HFD/STZ group, CrHis significantly increased body weight and reduced blood
glucose in diabetic rats (p < 0.001). Concentrations of Cr, Zn, Se, and Mn in serum, liver, and kidney of the diabetic rats were significantly lower
than in the control rats (p < 0.0001). In contrast, higher Fe and Cu levels were found in serum and tissues from diabetic versus the non-diabetic rats
(p < 0.001). Chromium histidinate supplementation increased serum, liver, and kidney concentrations of Cr and Zn both in diabetic
and non-diabetic rats (p < 0.001). Chromium supplementation increased Mn and Se levels in diabetic rats (p < 0.001); however, it decreased Cu levels in STZ-treated group (p < 0.001). Chromium histidinate supplementation did not affect Fe levels in both groups (p > 0.05). The results of the present study conclude that supplementing Cr to the diet of diabetic rats influences serum and
tissue Cr, Zn, Se, Mn, and Cu concentrations. 相似文献
6.
Tascilar ME Ozgen IT Abaci A Serdar M Aykut O 《Biological trace element research》2011,143(1):188-195
The quality of the diet of obese children is poor. Eating habits may alter micronutrient status in obese patients. In this
study, we determined the serum levels of selenium, zinc, vanadium, molybdenum, iron, copper, beryllium, boron, chromium, manganese,
cobalt, silver, barium, aluminum, nickel, cadmium, mercury, and lead in obese Turkish children. Thirty-four obese and 33 healthy
control subjects were enrolled in the study. Serum vanadium and cobalt levels of obese children were significantly lower than
those of the control group (0.244 ± 0.0179 vs. 0.261 ± 0.012 μg/l, p < 0.001, and 0.14 ± 0.13 vs. 0.24 ± 0.15 μg/l, p = 0.011, respectively). There was no significant difference between groups regarding the other serum trace element levels.
In conclusion, there may be alterations in the serum levels of trace elements in obese children and these alterations may
have a role in the pathogenesis of obesity. 相似文献
7.
Lucianna Fernandes J. C. Marques Carmen Marino Donangelo Juliana Gastao Franco Luciane Pires Aderval Severino Luna Gustavo Casimiro-Lopes Patricia Cristina Lisboa Josely Correa Koury 《Biological trace element research》2011,142(3):415-423
Intense physical activity is associated with biological adaptations involving hormones and trace elements. Zinc supplementation
may affect plasma copper concentration, thyroid-stimulating hormone (TSH), thyroid hormones, insulin, and glucose homeostasis,
but data in athletes are scarce. The aim of this study was to evaluate in competitive athletes (cyclists, n = 7, 32 ± 8 years) the effect of zinc supplementation (22 mg/day as zinc gluconate) during 30 days, and discontinuation using
placebo (maltodextrin) during the following 30 days, on plasma zinc and copper concentrations, serum thyroid hormones, insulin
and glucose levels, and HOMA2-IR. Compared to baseline, plasma zinc and Zn:Cu plasma ratio increased, but plasma copper decreased
after zinc supplementation (day 30) and discontinuation (day 60) (p < 0.05). Zn supplementation and discontinuation had no effect on TSH, T3, and T4. Fasting serum insulin and HOMA2-IR increased
(27% and 47%, respectively) on day 60 compared to baseline (p = 0.03), suggesting a delayed effect of zinc supplementation. Moreover, plasma zinc was positively associated with serum
insulin (r = 0.87, p = 0.009) and HOMA2-IR (r = 0.81, p = 0.03) after zinc supplementation (day 30), indicating that supplemental zinc may impair glucose utilization in cyclists. 相似文献
8.
Neural tube defects are important causes of infant mortality and childhood morbidity. We investigated the relationship between
zinc, selenium, copper, and lead concentrations and neural-tube-defect occurrence in women with a second-trimester termination
due to fetal-neural-tube defects (NTDs) in this case-control study. Fourteen pregnant women whose pregnancies were terminated
as a result of second-trimester ultrasonographic diagnosis of neural tube defects were recruited as cases. The control group
(n=14) consisted of women who were selected among age-, gravidity-, and socio-economic-state (SES)-matched women who had a normal
triple-screen and targeted ultrasound during the second trimester with documented normal fetal outcome. Zinc and copper determinations
were made using flame atomic absorption spectrophotometer (AAS). Graphite furnace AAS was used for Pb, and Se levels were
measured with hydride generation AAS. Cases had significantly low serum zinc and selenium levels (62.48±15.9 vs 102.6±23.7
and 55.16±11.3 vs 77.4±5.5, respectively, p<0.001). Serum Cu and whole-blood Pb levels were significantly high when compared to controls. There was a negative correlation
between serum zinc and selenium levels, and serum copper levels (r=−425 and −0.443, p<0.05). Our results are consistent with some previous reports. The etiology of NTDs cannot be explained with one strict etiologic
mechanism. On the contrary, an interaction among environmental, genetic, and nutritional factors such as trace elements and
vitamins would explain these anomalies. If folic acid supplementation is given, additional Zn supplementation should be considered
for the further decrease in the recurrence and occurrence of NTDs. 相似文献
9.
Gürgöze MK Olçücü A Aygün AD Taskin E Kiliç M 《Biological trace element research》2006,111(1-3):23-29
In the present study, the serum and hair levels of zinc, selenium, and copper were determined in children with iron-deficiency
anemia (IDA). A total of 52 anemic children aged 1–4 yr constituted the study group. Fortysix healthy children acted as controls.
The copper and zinc levels were measured with an atomic absorption spectrophometer. Serum and hair selenium was determined
by a spectroflourometric method. The serum zinc and selenium concentrations in the IDA group were found to be significantly
lower and serum copper significantly higher than those in the controls (p<0.05). Lower iron, zinc, and selenium concentrations (p<0.001) but not copper were found in hair (p>0.05). 相似文献
10.
The serum concentrations of copper, zinc, iron, and cobalt and copper/zinc ratio were investigated in horses infected with
equine herpesvirus-1 (EHV-1). Nine horses were naturally infected with the virus and nine healthy horses served as controls.
The concentrations of copper, zinc, iron, and cobalt were determined spectrophotometrically in the blood serum of all horses.
The results were (expressed in micrograms per deciliters) copper 2.80 ± 0.34 vs 1.12 ± 0.44, zinc 3.05 ± 0.18 vs 0.83 ± 0.06,
iron 2.76 ± 0.17 vs 3.71 ± 0.69, cobalt 0.19 ± 0.37 vs 0.22 ± 0.45, and copper/zinc ratio 0.72 ± 0.38 vs 1.41 ± 0.36 for control
vs infected group, respectively. In conclusion, copper and zinc concentrations of the infected group were lower than the control
group (p < 0.001), whereas iron concentration and the copper/zinc ratio of the infected group were higher than the control group (p < 0.05 and p < 0.001). The cobalt concentration was not found to be statistically different between two groups. It might be emphasized
that copper/zinc ratio was significantly affected by the EHV-1 infection, so it could be taken into consideration during the
course of infection.
An erratum to this article can be found at 相似文献
11.
Mustafa Akil Umit Gurbuz Mursel Bicer Abdullah Sivrikaya Rasim Mogulkoc Abdulkerim Kasim Baltaci 《Biological trace element research》2011,142(3):651-659
The present study aims to evaluate the effect of selenium supplementation on lipid peroxidation and lactate levels in rats
subjected to acute swimming exercise. Thirty-two adult male rats of Sprague–Dawley type were divided into four groups. Group
1, control; group 2, selenium-supplemented; group 3, swimming control; group 4, selenium-supplemented swimming group. The
animals in groups 2 and 4 were supplemented with (i.p.) 6 mg/kg/day sodium selenite for 4 weeks. The blood samples taken from
the animals by decapitation method were analyzed in terms of erythrocyte-reduced glutathione (GSH), serum glutathione peroxidase
(GPx) and superoxide dismutase (SOD), and plasma malondialdehyde (MDA) and lactate using the colorimetric method, and serum
selenium values using an atomic emission device. In the study, the highest MDA and lactate values were found in group 3, while
the highest GSH, GPx and SOD values were obtained in group 4 (p < 0,001). Group 2 had the highest and group 3 had the lowest selenium levels (p < 0,001). Results of the study indicate that the increase in free radical production and lactate levels due to acute swimming
exercise in rats might be offset by selenium supplementation. Selenium supplementation may be important in that it supports
the antioxidant system in physical activity. 相似文献
12.
Ersan Kara Mehmet Gunay İbrahim Cicioglu Mehmet Ozal Mehmet Kilic Rasim Mogulkoc Abdulkerim Kasim Baltaci 《Biological trace element research》2010,134(1):55-63
This study aims to examine the effect of zinc supplementation on free-radical formation and antioxidant system in individuals
who are actively engaged in wrestling as a sport. The study registered a total of 40 male subjects, of whom 20 were wrestlers
and 20 were sedentary individuals. The subjects were equally allocated to four groups: group 1, zinc-supplemented sportsmen
group; group 2, sportsmen group without supplementation; group 3, zinc-supplemented sedentary group; group 4, sedentary group
without supplementation. Blood samples were collected from all subjects twice, once at the beginning of the study and once
again at the end of 8-week procedures. The blood samples collected were analyzed to determine the levels of malondialdehyde
(MDA), serum glutathione (GSH), serum glutathione peroxidase (GPx) activity, serum superoxide dismutase (SOD) activity (ELISA
colorimetric method) and zinc (colorimetric method). No difference was found between MDA levels of the study groups in the
beginning of the study. The highest MDA value at the end of the study was obtained in group 4 (p < 0.01). MDA levels in group 2 were established to be significantly higher than those in groups 1 and 3 (p < 0.01). GSH level, GPx, and SOD activities and zinc level measured in the beginning of the study were not different between
groups. Measurements performed at the end of the study showed that groups 1 and 3 (zinc-supplemented groups) had the highest
GSH level, GPx, and SOD activities and zinc level (p < 0.01). These parameters were not different in the groups without supplementation (groups 2 and 4). Results obtained at
the end of the study indicate that zinc supplementation prevents production of free radicals by activating the antioxidant
system. In conclusion, physiologic doses of zinc supplementation to athletes may beneficially contribute to their health and
performance. 相似文献
13.
The effects of magnesium supplementation on plasma magnesium, zinc, and copper levels were determined in young adult tae-kwon-do
athletes and sedentary controls at rest and exhaustion. After a 4-week supplementation period with 10 mg/day/kg Mg, the plasma
magnesium, copper, and zinc levels significantly increased in sedentary and training (90–120 min training 5 days a week) subjects
when compared to nonsupplemented controls (p < 0.05). 相似文献
14.
Lu Rongzhu Wang Suhua Xing Guangwei Ren Chunlan Han Fangan Jing Junjie Michael Aschner 《Biological trace element research》2009,130(1):39-47
The mechanism of toxicity of acrylonitrile (AN) has not been fully defined. The research described herein was undertaken to
investigate the possible effects of AN on the levels of metallic elements in liver and brain of mice. Thirty-two mice were
randomly assigned to four separate groups and treated intraperitoneal (i.p.) once daily for 1 week. Mice in the control group
received normal saline, and mice in the three exposure groups received 5, 10, or 20 mg AN/kg b.w. Samples of brain and liver
were collected immediately after decapitation. Tissue levels of trace elements (zinc, copper, iron) were determined with flame
atomic absorption spectrophotometer or double channel atomic fluorescence absorption spectrophotometer (selenium). Mean brain
weights of AN-treated mice were increased as a function of dose compared to controls, but there was no significant change
in the ratio of liver/body weight in the four groups. While mean brain zinc decreased as a function of AN dosage, mean liver
zinc of the low-dose group significantly increased (p < 0.05); mean liver copper in the medium-dose AN group was significantly higher compared to controls (p < 0.05); however, mean brain copper was increased, but the difference did not attain statistical significance in the three
AN groups when compared with the controls (p > 0.05). Mean brain iron levels were significantly decreased in the middle-dose AN group (p < 0.05), but there were no consistent changes in liver iron. Tissue levels of selenium in brain and liver were similar for
the control and AN treatment groups. AN induces significant and differential changes in the levels of zinc, copper, and iron
in brain and liver. These changes likely play a pivotal role in mediating AN toxicity, most likely via changes in cellular
redox status. 相似文献
15.
Dietary Zinc Glycine Chelate on Growth Performance,Tissue Mineral Concentrations,and Serum Enzyme Activity in Weanling Piglets 总被引:2,自引:0,他引:2
One hundred twenty crossbred piglets (Duroc × Landrace × Yorkshire) were used to determine the effects of dietary zinc glycine
chelate on growth performance, tissue mineral concentrations, and serum enzyme activity. All pigs were allotted to four treatments
and fed with basal diets supplemented with 0, 50, and 100 mg/kg Zn as zinc glycine chelate or 3,000 mg/kg Zn as zinc oxide
(ZnO). After the 35-day feeding trial, results of the study showed that, compared to the control, average daily gain was improved
(P < 0.05) for pigs fed 100 mg/kg Zn from zinc glycine chelate or 3,000 mg/kg Zn from ZnO and Zn concentrations in serum and
M. longissimus dorsi were significantly enhanced by 100 mg/kg dietary zinc glycine chelate and 3,000 mg/kg ZnO. In addition, supplementation of
100 mg/kg zinc glycine chelate decreased (P < 0.05) the liver Fe level, liver Zn level, spleen Cu level, and kidney Cu level compared to that of the 3,000-mg/kg ZnO
group. For feces mineral excretion, 3,000 mg/kg Zn from ZnO greatly increased the concentration of fecal Zn (P < 0.01) and Mn (P < 0.05) compared to that of the control or the 100-mg/kg zinc glycine chelate group. Moreover, alkaline phosphatase and Cu/Zn
superoxide dismutase activities of pigs in 100 mg/kg zinc glycine chelate and ZnO treatments were greatly higher than that
of the control. The results of present study showed that supplementation with zinc glycine chelate could improve growth and
serum enzyme activities and could also decrease zinc excretion in feces in weanling pig compared to high dietary ZnO. 相似文献
16.
Milan Dastych Dagmar Procházková Antonin Pokorný Libor Zdražil 《Biological trace element research》2010,133(3):265-269
The purpose of this study was to determine the different levels of copper and zinc in the serum, urine, and scalp hair of
patients with Wilson’s disease receiving different, currently accepted methods of treatment to reduce the copper load (penicillamine—group
1, n = 8; zinc—group 2, n = 8; penicillamine+zinc—group 3, n = 8). Blood, urine, and hair samples were collected from the patients. All three treatments resulted in a significant decrease
of the serum copper levels. Significantly increased levels of zinc in the serum were detected in the patients in groups 2
and 3 (19.1 and 18.8 μmol/l, respectively; p < 0.05). Copper excretion in the urine significantly increased during its administration to groups 1 and 3 (11.5 and 7.94 μmol/24 h
respectively; p < 0.001) due to the effect of penicillamine. The administration of zinc as monotherapy (group 2) or in combination with penicillamine
(group 3) led to an increase of its excretion (25.3 and 22.4 μmol/24 h, respectively; p < 0.01). Only an insignificant rise of the copper content in the hair was found in all three groups of patients. The content
of zinc in the hair did not differ significantly in any of the groups in comparison with the control group. 相似文献
17.
Hasan Aydın Oğuzhan Deyneli Dilek Yavuz Hülya Gözü Nilgün Mutlu Işık Kaygusuz Sema Akalın 《Biological trace element research》2010,133(2):136-143
Magnesium has been shown to increase bone mineral density when used in the treatment of osteoporosis, yet its mechanism of
action is obscure. In this study, the effects of daily oral magnesium supplementation on biochemical markers of bone turnover
were investigated. Twenty postmenopausal women have been divided into two groups. Ten patients were given magnesium citrate
(1,830 mg/day) orally for 30 days. Ten postmenopausal women of matching age, menopause duration, and BMI were recruited as
the control group and followed without any medication. Fasting blood and first-void urine samples were collected on days 0,
1, 5, 10, 20, and 30, respectively. Total magnesium, calcium, phosphorus, iPTH and osteocalcin were determined in blood samples.
Deoxypyridinoline levels adjusted for creatinine were measured in urine samples. Thirty consecutive days of oral magnesium
supplementation caused significantly decrease in serum iPTH levels in the Mg-supplemented group (p < 0.05). Serum osteocalcin levels were significantly increased (p < 0.001) and urinary deoxypyridinoline levels were decreased (p < 0.001) in the Mg-supplemented group. This study has demonstrated that oral magnesium supplementation in postmenopausal
osteoporotic women suppresses bone turnover. 相似文献
18.
We have determined the trace element composition of anti-influenza virus mushrooms using atomic absorption spectrophotometer.
The elements present in greater concentration in Ganoderma lucidum samples are selenium, iron, and zinc, with selenium being the element with the highest concentration of all, at 416 ± 38.5 mg/kg;
in Cordyceps militaris samples are iron, selenium, and zinc, with iron being the element with the highest concentration of all, at 291 ± 20.9 mg/kg;
in Kuehneromyces mutabilis samples are selenium, iron, and manganese, with selenium being the element with the highest concentration of all, at 203 ± 9.8
mg/kg; in Inonotus hispidus samples are zinc, selenium, and iron, with zinc being the element with the highest concentration of all, at 194 ± 16.9mg/kg;
in the Collybia maculata samples are iron, selenium, and zinc, with iron being the element with the highest concentration of all, at 274 ± 22.2 mg/kg,
respectively. The average metal concentrations in mushrooms decreases in the order: selenium > iron > zinc > chromium > manganese > copper > magnesium > lead.
After the mice were administered (orally) with mushroom extracts for 8 weeks and inoculated intranasally with viral suspension,
element levels in serum were also measured. Highly significantly increased values of Se, Zn, and Mg in the serum of mice supplemented
with anti-influenza virus mushrooms were a characteristic finding. Se, Zn, and Mg present in mushrooms may play a direct or
indirect role in their anti-influenza virus nature. They may provide prophylactic protection against influenza infection via
stimulation of host innate immune response. 相似文献
19.
X-ray radiation is detrimental to human cells and may lead to development of life-threatening diseases. Cigarette paper and
cigarette smoke contain toxic elements, whereas vitamins C and E (VCE) may have regulator effects on the elements. We investigated
effects of VCE administration on X-ray-induced element changes in blood of smoker and nonsmoker X-ray technicians. Twenty
technicians and 30 healthy age-matched control subjects were used in the study. Ten of the X-ray technicians and 15 of the
control were smokers. Blood serum samples were taken from the control. Oral vitamins C (500 mg) and E (150 mg) were supplemented
daily to the smoker and nonsmoker X-ray technicians for 5 weeks. Serum samples were taken from the X-ray technicians before
and after 5 weeks. Copper, zinc, selenium, aluminum, iron, magnesium, and calcium levels were investigated in control and
X-ray technicians, both smokers and nonsmokers. Copper, zinc, and selenium levels were lower in the total X-ray group and
smoker X-ray group than in control and nonsmoker X-ray group, although iron, magnesium, and calcium levels were higher in
X-ray group than in control. The copper, zinc, selenium, and aluminum levels were higher in the VCE treatment group than those
in X-ray group, although magnesium and calcium levels were decreased by the treatment. The serum zinc, copper, selenium, and
magnesium levels were lower in smoker control group when compared to nonsmoker control group. The serum zinc levels were lower
in smoker X-ray group than nonsmoker X-ray group, although iron level was higher in smoker X-ray group than in nonsmoker X-ray
group. VCE prevents the smoke and X-ray-induced selenium, zinc, magnesium, and copper decrease to strengthen the antioxidant
trace element levels in the serum of the technicians. 相似文献
20.
Lopes PA Santos MC Vicente L Rodrigues MO Pavão ML Nève J Viegas-Crespo AM 《Biological trace element research》2004,100(1):1-17
Serum levels of selenium, copper, and zinc were systematically determined in healthy subjects of the Lisbon population. The
sample consisted of 183 blood donors of both genders who were divided into two age groups: 20–44 and 45–70 yr of age; relationships
with gender, age, the lipid profile, and tobacco consumption were investigated. In the female group, the intake of oral contraceptives
and pregnancy were considered for the youngest women, and hormonal replacement therapy (HRT) was taken into account for the
oldest ones. Serum concentrations of these elements were in the same range as those found for populations of other European
countries. Differences between genders were observed for the three elements studied, with serum selenium and zinc concentrations
higher in men and copper levels higher in women. Age-dependent differences were found for selenium: The oldest subjects (regardless
gender) presented the highest concentrations of selenium in serum as further demonstrated by the positive correlation with
age. In both pregnant and contraceptive-using women, copper was greatly increased, confirming the influence of estrogen status
and/or oral contraceptive intake on increased serum copper levels. However, in postmenopausal women, HRT did not significantly
affect serum copper levels. Selenium, copper, and zinc status were not different between normolipidemic and hyperlipidemic
subjects for the same gender and age range, but selenium levels tended to increase with hyperlipidemia when considering the
whole group of subjects. With respect to the lifestyle, higher serum zinc levels were found in tobacco-consuming men. Albumin
serum levels were similar for all considered subgroups, except for the pregnant women, for whom a decrease in this parameter
was observed. The present study allowed one to obtain reference values for this healthy group of population, which will serve
for a comparative study with groups having pathological conditions, such as cardiovascular disease. 相似文献