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Brun-Buisson C 《Médecine sciences : M/S》2005,21(1):78-82
In addition to the IRB (Institutional review board), the DSMB (data safety and monitoring board) takes an increasing role in the monitoring of clinical trials, especially in large multicenter trials. The DSMB is a an expert committee, independent from the investigators and the sponsor of the trial, which periodically examines the safety data accumulated during progress of the trial and ensures that the benefit/risk ratio remains acceptable for participating patients. The DSMB is also a safeguard for the scientific integrity of the trial. It is the only committee which can have access to unblinded data from the trial. The DSMB may recommend termination of the trial in three situations : (1) occurrence of unanticipated adverse events which may pose a serious risk for participating patients; (2) demonstration of efficacy before the planned accrual \; (3) and because of "futility" (the most difficult situation), i.e. in absence of a reasonable probability that the trial may reach a conclusion within its planned frame. 相似文献
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Organizers Conference Free-Radical Mechanisms of Brain Pathologies: Theoretical Practical Aspects Moscow November –December Abstracts 《Neurochemical research》2001,26(7):859-865
Abstract List
Abstracts from Neirokhimiya, Vol. 17, No. 1, 2000 相似文献4.
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Philippe Janvier 《Geobios》1982,15(3):433-434
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Robert J. Wilson 《Journal of Insect Conservation》2010,14(4):423-424
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《动物学报》1962,(2)
This is the second part of a series of papers dealing with the Copepoda-fauna of theWu-Li Lake, Wu-Sih, Kiangsu Province, China. It comprises 21 species of Cyclopoida,of which 5 species (those marked with an asterisk in the list) are for the first time re-corded in China and two species of Tropocyclops are found to be new to science. All 相似文献
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