Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A

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Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex

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PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway

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RIPK1 Promotes Energy Sensing by the mTORC1 Pathway

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RIF1 suppresses the formation of single-stranded ultrafine anaphase bridges via protein phosphatase 1

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IQGAP1 Negatively Regulates HIV-1 Gag Trafficking and Virion Production

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TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1

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Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors

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Self-incompatibility requires GPI anchor remodeling by the poppy PGAP1 ortholog HLD1

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A non-canonical target-binding site in Munc18-1 domain 3b for assembling the Mint1-Munc18-1-syntaxin-1 complex

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HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway

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Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism

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H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ

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Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes

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Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation

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Molecular insight into the PCNA-binding mode of FBH1

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HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways

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Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA

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Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex

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Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery

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