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Mucous cysts: the dorsal distal interphalangeal joint ganglion 总被引:1,自引:0,他引:1
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Introduction
Cervical cancer is among the most common cancers in women worldwide. Discovery of biomarkers for the early detection of cervical cancer would improve current screening practices and reduce the burden of disease.Objective
In this study, we report characterization of the human cervical mucous proteome as the first step towards protein biomarker discovery.Methods
The protein composition was characterized using one- and two-dimensional gel electrophoresis, and liquid chromatography coupled with mass spectrometry. We chose to use this combination of traditional biochemical techniques and proteomics to allow a more comprehensive analysis.Results and Conclusion
A total of 107 unique proteins were identified, with plasma proteins being most abundant. These proteins represented the major functional categories of metabolism, immune response, and cellular transport. Removal of high molecular weight abundant proteins by immunoaffinity purification did not significantly increase the number of protein spots resolved. We also analyzed phosphorylated and glycosylated proteins by fluorescent post-staining procedures. The profiling of cervical mucous proteins and their post-translational modifications can be used to further our understanding of the cervical mucous proteome. 相似文献4.
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BRYGOO ER 《Annales de l'Institut Pasteur》1952,83(6):820-822
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Mucous cells of the tracheobronchial tree in the ferret 总被引:1,自引:0,他引:1
Mucosubstances in the tracheobronchial tree of the ferret were studied histochemically. The submucous glands contained predominantly neutral mucins. Scattered between these were cells containing sulphated mucins and sialidase-labile and sialidase-resistant sialomucins. Most of the goblet cells in the trachea, as well as those in the bronchi and larger bronchioles, contained sulphated mucins. A smaller proportion of the goblet cells showed sialidase-labile and sialidase-resistant sialomucins. It will be interesting to see whether ferrets can be used to produce animal models for hypersecretory diseases such as cystic fibrosis and chronic bronchitis. 相似文献
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Summary Mucosubstances in the tracheobronchial tree of the ferret were studied histochemically. The submucous glands contained predominantly neutral mucins. Scattered between these were cells containing sulphated mucins and sialidase-labile and sialidase-resistant sialomucins. Most of the goblet cells in the trachea, as well as those in the bronchi and large pronchioles, contained sulphated mucins. A smaller proportion of the goblet cells showed sialidase-labile and sialidase-resistant sialomucins. It will be interesting to see whether ferrets can be used to produce animal models for hypersecretory diseases such as cystic fibrosis and chronic bronchitis. 相似文献
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Whether mental operations can be reduced to the biological properties of the brain has intrigued scientists and philosophers alike for millennia. New microstimulation experiments on awake, behaving monkeys establish causality between activity of specialized cortical neurons and a controlled behavior. 相似文献
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In this study dermatoglyphic traits in 16 populations in northern Hungary were examined. The occurrence and probability of the manifestation of finger pattern types were analysed. Certain relationships were found that show that if a given pattern type is present on one of the fingers, then, in these cases, the frequency of pattern types on the other nine fingers typically is different from that in the entire sample. We termed this relationship or effect; pattern influence. In most cases there was a strong significant difference in frequency values between the entire sample and the studied cases. We studied the relationship of populations and pattern types using correspondence analysis. In the entire sample, most populations are located around the ulnar loop and the whorl. This arrangement is significantly and typically different in pattern-influence cases. Most populations aggregated around the pattern type in which pattern influence was studied. Pattern influence was found in all populations studied, and in both sexes. 相似文献
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KOPEC M SENDYS N KOWALSKI E 《Polski tygodnik lekarski (Warsaw, Poland : 1960)》1950,5(51-52):1766-1768
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The life cycle of the malaria parasite (Plasmodium) is remarkably complex. Malaria parasites must engage in highly specific and varied interactions with cell types of both the mammalian host and the mosquito vector. In this issue of Cell, report detailed molecular insights into an intimate interaction between a malaria parasite protein and its host cell receptor that enables the parasite to invade erythrocytes. 相似文献
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H. Moe 《Biotechnic & histochemistry》1952,27(3):141-146
A method is described for determining the number of goblet cells of the villi and crypts of Lieberkuhn in the small intestine with an accuracy far exceeding that which appears to be possible by counting on tissue sections. In groups of intact villi or crypts, previously isolated by microdissection, the goblet cells are stained, with as little staining as possible of the other tissue elements; thereafter the preparations are made transparent by embedding in a medium possessing a refractive index similar to that of the tissue. The staining is performed by the McManus-Hotchkiss periodic-leucofuchsin method (1948) with the modification that SchifPs reagent is diluted with 3 parts of water, the staining period cut down to 2V4-3 minutes, and the rinsing with bisulfite solution to 4-6 minutes. The embedding medium consists of colophonium and quinine hydrochloride in anise oil (Aurell, 1938). By this procedure, all the stained cells of the preparation may be visualized by manipulating the fine adjustment of the microscope. Counting of the goblet cells of the villi may be performed with great accuracy by projecting the picture of the preparation from the microscope on sectional paper and placing dots in the positions of the stained cells. The degree of magnification is determined by a corresponding projection of the scale of a micrometer disc. 相似文献
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Targeting the sticky fingers of HIV-1 总被引:1,自引:0,他引:1
Although human blood plasma contains molecules that inhibit the activity of HIV-1, their identity is largely unknown. Münch et al. (2007) now identify a peptide corresponding to a portion of alpha1-antitrypsin that potently inhibits entry of HIV-1 into host cells by binding to a hydrophobic segment of the viral envelope glycoprotein gp41. 相似文献