健康宣教在小儿狭窄性腱鞘炎围手术期应用价值

目的：对手术疗法治疗狭窄性腱鞘炎的小儿患者采取系统的整体健康宣教,使得患儿疗程缩短,治愈率高,复发率降至最低,功能康复效果良好,提高护理质量。方法：在保守治疗无效的情况下,手术疗法切除部分狭窄腱鞘,围手术期实施系统的全面的功能康复训练及宣教。结果：54例患儿完全治愈,随访3~26个月,无复发及并发症,愈后功能良好。结论：细致、周密的做好围手术期对家长及患儿的双重健康宣教工作,使得护患关系融洽,患者自护能力大大加强,治疗及护理效果满意。     

健康宣教在小儿狭窄性腱鞘炎围手术期应用价值

目的:对手术疗法治疗狭窄性腱鞘炎的小儿患者采取系统的整体健康宣教,使得患儿疗程缩短,治愈率高,复发率降至最低,功能康复效果良好,提高护理质量。方法:在保守治疗无效的情况下,手术疗法切除部分狭窄腱鞘,围手术期实施系统的全面的功能康复训练及宣教。结果:54例患儿完全治愈,随访3~26个月,无复发及并发症,愈后功能良好。结论:细致、周密的做好围手术期对家长及患儿的双重健康宣教工作,使得护患关系融洽,患者自护能力大大加强,治疗及护理效果满意。     

超声联合手部滑膜炎与腱鞘炎判断RA患者的疾病活动度的可行性

摘要 目的：探究超声联合手部滑膜炎与腱鞘炎判断RA患者的疾病活动度的可行性。方法：选择2018年9月至2019年9月我院收治的103例RA患者,采用GS和PD超声检查患者手部关节和腱鞘,比较超声指标与DAS28-CRP的相关性以及超声检查手部滑膜炎与联合检查手部滑膜炎和腱鞘炎对病情诊断情况的差异。结果：关节GS总分、关节PD总分、腱鞘GS总分、腱鞘PD总分、联合GS总分、联合PD总分与DAS28-CRP均显著相关（P<0.05）。在基于DAS28-CRP的情况下,对比超声只检查手部滑膜炎与超声检查手部滑膜炎和腱鞘炎时发现：只存在腱鞘炎患者共有9名,即9名患者将被认为病情缓解,占所有患者的8.70 %。结论：超声联合手部滑膜炎与腱鞘炎可以更准确地评估患者疾病活动度,减少误诊或遗漏的概率,值得在临床推广使用。     

注射器针头划拨法治疗儿童拇指狭窄性腱鞘炎的临床疗效及与病程的关系

目的:探讨注射器针头划拨法治疗儿童拇指狭窄性腱鞘炎临床疗效,分析病程长短与治疗效果的相关性。方法:纳入2015年4月至2018年10月于我院治疗的拇指狭窄性腱鞘炎患儿59例,根据患儿发病时间分为短程组(发病时间≤6个月,n=28)和长程组(发病时间6个月,n=31),所有患儿采用7#注射器针头划拨法进行治疗,术后1个月及6个月门诊复查并评定临床疗效,观察记录是否残留屈曲挛缩,触发弹响感、主动屈伸拇指指间关节活动度改善情况及术后并发症情况,分析两组患儿病程与治疗效果相关性,记录术后随访结果。结果:短程组治疗有效率为96.43%,长程组治疗有效率为93.55%,两组有效率比较无统计学差异(P0.05)。术后1个月及6个月复查56例患儿均成功解除屈曲挛缩畸形,主动屈伸拇指指间关节活动度改善情况满意,触发激痛点消失,后续随访6～46个月未见复发,未愈的3例患儿经外科手术治疗后达到治愈效果。两组患儿病程长短与治疗效果不存在线性相关性(P0.05)。结论:注射器针头划拨法治疗儿童拇指狭窄性腱鞘炎临床疗效确切,治疗器械普通,创口小,简单易行,在治疗病程大于6个月的儿童拇指狭窄性腱鞘炎也能取得较满意的临床疗效。     

Embryo and Endosperm Function and Failure inSolanumSpecies and Hybrids

Although the importance of the endosperm as a food store inmany angiosperm seeds is well known, its significance duringearly embryogenesis has been neglected. In many interspecifichybrids, and in some other situations, embryos do not developfully and abort. It has often been stated that this is causedby the endosperm failing to conduct sufficient nutrients tothe embryo, but seldom has it been suggested that the endospermactively controls most of the early stages of morphogenesisof the embryo. Information gleaned from a broad survey of theliterature, combined with additional evidence presented here,obtained fromSolanum incanumand interspecific hybrids, indicatethat the endosperm is dynamic and very active in regulatingearly embryo development. This requires highly integrated geneticcontrol of rapidly changing metabolism in the endosperm. Ininterspecific hybrids, lack of coordination may cause unbalancedproduction of growth regulating substances by the endospermand hence abortion of the embryo, or even unregulated productionof nucleases and proteases resulting firstly in autolysis ofthe endosperm and then digestion of the embryo. The endospermmay thus serve to detect inappropriate hybridization of speciesor ploidy levels and so prevent waste of resources by producingseeds that would result in sterile hybrids or unthrifty subsequentgenerations. This discriminatory function of the endosperm hasdiminished during evolution and domestication of the crop plantSolanummelongenaL.Copyright 1998 Annals of Botany Company Solanum, embryo morphogenesis, endosperm, hybrid, seed development.     

环腺苷酸应答元件结合蛋白与学习记忆

环腺苷酸(cAMP)应答元件结合蛋白(cAMP response element binding protein,CREB)是一种核转录因子,可与cAMP反应元件结合,调节基因转录,具有调节精子生成,昼夜节律,学习记忆等功能.近年来关于其在学习记忆中的作用成为医学研究热点.CREB是神经元内多条信息传递途径的汇聚点,参与长时记忆形成和突触可塑性.长时记忆(long-term memory)形成需依赖CREB介导的基因转录,干扰或抑制CREB活性可破坏长时记忆.长时程增强(long-term potentiation,LTP)是研究学习记忆的理想模型,在LTP诱导和维持过程中均可观察到CREB活性持续升高.但增龄过程中,海马CREB活性下降,影响学习记忆功能,与许多神经退行性疾病发生有关.     

HIFs and tumors--causes and consequences

For most organisms oxygen is essential fo life. When oxygen levels drop below those required to maintain the minimum physiological oxygen requirement of an organism or tissue it is termed hypoxia. To counter act possible deleterious effects of such a state, an immediate molecular response is initiated causing adaptation responses aimed at cell survival. This response is mediated by the hypoxia-inducible factor-1 (HIF-1), which is a heterodimer consisting of an alpha- and a beta-subunit. HIF-1 alpha protein is stabilized under hypoxic conditions and therefore confers selectivity to this response. Hypoxia is characteristic of tumors, mainly because of impaired blood supply resulting from abnormal growth. Over the past few years enormous progress has been made in the attempt to understand how the activation of the physiological response to hypoxia influences neoplastic growth. In this review some aspects of HIF-1 pathway activation in tumors and the consequences for pathophysiology and treatment of neoplasia are discussed.