共查询到20条相似文献,搜索用时 218 毫秒
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Seidametova E. A. Shakirzyanova M. R. Ruzieva D. M. Gulyamova T. G. 《Applied Biochemistry and Microbiology》2004,40(6):560-562
A method of adaptation to cobalt nitrate at high concentrations allowed us to isolate 46 strains of propionic acid bacteria Propionibacterium acidipropionici, resistant to excessive amounts of Co2+ in the medium. Studies of these strains revealed cultures that were most potent in synthesizing vitamin B12. The yield of vitamin B12 was increased 3 times, compared to parent strains. 相似文献
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A third vitamin B12 binding protein present in normal serum has been shown to participate in transport of labelled vitamin B12 absorbed from the gut. All three vitamin B12 binding proteins in serum were labelled at the same time after oral administration of vitamin B12, implying that “free” vitamin B12 reached the portal blood from the gut mucosa. 相似文献
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Toshiko Tanaka Paul Scheet Betti Giusti Stefania Bandinelli Maria Grazia Piras Gianluca Usala Sandra Lai Antonella Mulas Anna Maria Corsi Anna Vestrini Francesco Sofi Anna Maria Gori Rosanna Abbate Jack Guralnik Andrew Singleton Goncalo R. Abecasis David Schlessinger Manuela Uda Luigi Ferrucci 《American journal of human genetics》2009,84(5):712
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Bj?rn Regland Sara Forsmark Lena Halaouate Michael Matousek Birgitta Peilot Olof Zachrisson Carl-Gerhard Gottfries 《PloS one》2015,10(4)
Background
Patients with myalgic encephalomyelitis (ME, also called chronic fatigue syndrome) may respond most favorably to frequent vitamin B12 injections, in vital combination with oral folic acid. However, there is no established algorithm for individualized optimal dosages, and rate of improvement may differ considerably between responders.Objective
To evaluate clinical data from patients with ME, with or without fibromyalgia, who had been on B12 injections at least once a week for six months and up to several years.Methods
38 patients were included in a cross-sectional survey. Based on a validated observer’s rating scale, they were divided into Good (n = 15) and Mild (n = 23) responders, and the two groups were compared from various clinical aspects.Results
Good responders had used significantly more frequent injections (p<0.03) and higher doses of B12 (p<0.03) for a longer time (p<0.0005), higher daily amounts of oral folic acid (p<0.003) in good relation with the individual MTHFR genotype, more often thyroid hormones (p<0.02), and no strong analgesics at all, while 70% of Mild responders (p<0.0005) used analgesics such as opioids, duloxetine or pregabalin on a daily basis. In addition to ME, the higher number of patients with fibromyalgia among Mild responders was bordering on significance (p<0.09). Good responders rated themselves as “very much” or “much” improved, while Mild responders rated “much” or “minimally” improved.Conclusions
Dose-response relationship and long-lasting effects of B12/folic acid support a true positive response in the studied group of patients with ME/fibromyalgia. It’s important to be alert on co-existing thyroid dysfunction, and we suspect a risk of counteracting interference between B12/folic acid and certain opioid analgesics and other drugs that have to be demethylated as part of their metabolism. These issues should be considered when controlled trials for ME and fibromyalgia are to be designed. 相似文献20.
Alternate Requirement for Vitamin B12 or Methionine in Mutants of Pseudomonas denitrificans, a Vitamin B12-producing Bacterium 总被引:4,自引:2,他引:2 下载免费PDF全文
Experiments are described which indicate that Pseudomonas denitrificans, an organism that overproduces vitamin B(12), uses the B(12) pathway exclusively for methionine synthesis. 相似文献