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1.
BackgroundThe number of known boron-containing compounds (BCCs) is increasing due to their identification in nature and innovative synthesis procedures. Their effects on the fungal kingdom are interesting, and some of their mechanisms of action have recently been elucidated.MethodsIn this review, scientific reports from relevant chemistry and biomedical databases were collected and analyzed.ResultsIt is notable that several BCC actions in fungi induce social and economic benefits for humans. In fact, boric acid was traditionally used for multiple purposes, but some novel synthetic BCCs are effective antifungal agents, particularly in their action against pathogen species, and some were recently approved for use in humans. Moreover, most reports testing BCCs in fungal species suggest a limiting effect of these compounds on some vital reactions.ConclusionsNew BCCs have been synthesized and tested for innovative technological and biomedical emerging applications, and new interest is developing for discovering new strategic compounds that can act as environmental or wood protectors, as well as antimycotic agents that let us improve food acquisition and control some human infections. 相似文献
2.
J. De Rudder J. Leclerc M Mercier G. Gosselin J. L. Imbach 《Nucleosides, nucleotides & nucleic acids》2013,32(1-2):221-223
Abstract D-Xylo and Lyxofuranonucleosides have not been extensively studied. Therefore in order to perform a systematic Structure-Antiviral Activity Relationship of the nucleoside analogs we have first synthesized their α and β anomers, some of them being unknown or their structure doubtful in the literature. 相似文献
3.
Dan Peters Anna-Britta Hörnfeldt Salo Gronowitz Nils Gunnar Johansson 《Nucleosides, nucleotides & nucleic acids》2013,32(6):1151-1173
Abstract 5-Cyclopropyl-2′-deoxycytidine and some 5-aryl-2′-deoxyuridines and -cytidines have been prepared and their inhibition of HIV have been tested. 相似文献
4.
《Revista iberoamericana de micología》2014,31(2):119-124
BackgroundMany Alternaria species have been studied for their ability to produce bioactive secondary metabolites, such as tentoxin (TEN), some of which have toxic properties. The main food contaminant toxins are tenuazonic acid, alternariol (AOH), alternariol monomethyl ether (AME), altenuene, and altertoxins i, ii and iii.AimsTo determine the profiles of secondary metabolites characteristic of Alternaria strains isolated from tomato for their chemotaxonomic classification.MethodsThe profiles of secondary metabolites were determined by HPLC MS.ResultsThe Alternaria isolates obtained from spoiled tomatoes belong, according to their morphological characteristics, to the species groups Alternaria alternata, Alternaria tenuissima and Alternaria arborescens, with A. tenuissima being the most frequent. The most frequent profiles of secondary metabolites belonging to the species groups A. alternata (AOH, AME, TEN), A. tenuissima (AOH, AME, TEN, tenuazonic acid) and A. arborescens (AOH, AME, TEN, tenuazonic acid) were determined, with some isolates of the latter being able to synthesize AAL toxins.ConclusionsSecondary metabolite profiles are a useful tool for the differentiation of small spored Alternaria isolates not easily identifiable by their morphological characteristics. 相似文献
5.
Abstract In this work we have considered the features of thecal plates of some mediterranean species of Podolampas. The thecal plates have pores different in size and distribution according to their position and to the species considered. We have found some constant structures: kind of perforations of the apical, preequatorial and postequatorial thecal plates. The antiapical thecal plates have both constant and distinctive specific features. 相似文献
6.
BackgroundParasitic infections are a public health problem since they have high morbidity and mortality worldwide. In parasitosis such as malaria, leishmaniasis and trypanosomiasis it is necessary to develop new compounds for their treatment since an increase in drug resistance and toxic effects have been observed. Therefore, the use of different compounds that couple vanadium in their structure and that have a broad spectrum against different parasites have been proposed experimentally.ObjectiveReport the mechanisms of action exerted by vanadium in different parasites.ConclusionIn this review, some of the targets that vanadium compounds have were identified and it was observed that they have a broad spectrum against different parasites, which represents an advance to continue investigating therapeutic options. 相似文献
7.
Marwa Zayane Ameur Rahmouni Mejda Daami-Remadi Mohamed Ben Mansour Anis Romdhane 《Journal of enzyme inhibition and medicinal chemistry》2016,31(6):1566-1575
We designed and synthesized new series of diverse triazoles, isoxazoles, isoxazolines, and aziridines linked 4-methylumbelliferone 1 using intermolecular 1,3-dipolar cycloaddition reactions. Structures of these compounds were established on the basis of 1H NMR, 13C NMR, and ESI-HRMS. All prepared compounds were evaluated for their antimicrobial, anticoagulant, and anticholinesterase activities. Interestingly, among the tested molecules, some of the analogs displayed better activities than the parent 4-methylumbelliferone 1 such as 6a and 6d for their antifungal properties. Moreover, compounds 4, 5, 6, and 7 showed the importance of the added fragments to 4-methylumbelliferone 1 via the linker methylene to have good activity. 相似文献
8.
D. Cech C.-D. Pein E. A. Kubareva E. S. Gromova T. S. Oretskaya Z. A. Shabarova 《Nucleosides, nucleotides & nucleic acids》2013,32(5-6):585-588
Abstract To study the interaction of the restriction endonucleases Mval and Eco RII with DNA we have synthesized some modified oligonucleotides. The results of hydrolysis demonstrate that both enzymes cleave their substrate by different mechanism. 相似文献
9.
《Revista espa?ola de geriatría y gerontología》2021,56(6):361-363
BackgroundThe acceleration of the epigenetic clock has been associated with a reduction in life expectancy. Individuals diagnosed with a psychiatric disorder have a reduction in life expectancy, and some studies have correlated it with accelerated aging.ObjectiveThe present study aims to explore whether the presence of any psychiatric disorder could accelerate the epigenetic clock in monozygotic twins.MethodsA total of 15 pairs of monozygotic twins were included. Epigenetic age in peripheral blood cells was estimated by previously published algorithms, using the 450K Beadchip microarray.ResultsWe found that in twins with a diagnosis of a psychiatric disorder, the epigenetic clock could increase compared to their twin without a psychiatric disorder.Discussion and conclusionThe presence of some psychiatric disorder could accelerate the epigenetic clock in homozygous twins, but studies with larger samples are required to clarify this relationship. 相似文献
10.
《Journal of enzyme inhibition and medicinal chemistry》2013,28(3):323-330
An ideal anti-inflammatory drug should have the desired effect in minimum dose with minimum side effects. Antimicrobial actions associated with such agents will be an added advantage as they broaden the spectrum of the compounds. Promising anti-inflammatory and antimicrobial activity together with low ulcerogenic properties of some 2(3H)-furanones, synthesized in our previous study, prompted us to investigate the effect of the isobutyl group on their pharmacological profile. Since compounds 3, 9, 13, and 14 have both anti-inflammatory and analgesic effects in addition to low ulcerogenic incidence, they were selected for investigation of their inhibitory effects on various cyclo-oxygenase enzymes. It was found that they were more selective toward COX-2 enzymes. An MIC of 6.25 μg/mL was recorded for compounds 3, 13, and 14 against S. aureus, E. coli, R. oryza, and P. citrum. The study supports the development of furanone derivatives as potential anti-inflammatory agents with antimicrobial activity. 相似文献
11.
Yi Zhang Chang-Zhong Liu Xiao-Jun Li Zi-Liang Wang Hai-Tang Zhang Zhi-Guo Miao 《Journal of molecular modeling》2010,16(8):1369-1376
The radicals and anions generated from chlorpyrifos by removing a hydrogen atom have been investigated using the hybrid density
functional B3PW91 method. The results show that all the radicals have been classified as three groups and their stability
order is methylene (radical 1, 3, 5, and 7) > methyl (radical 9, 11 and 13) > ring (15); the anions have the relative energetic order: methyl > methylene > ring. Moreover, some decomposition reactions are also
reported. The large HOMO-LUMO gaps indicate that both radicals and anions are predicted to be high-kinetic stable molecules.
We also find that radicals 9, 11 and 13 have the highest AEAs and anions 2, 4 and 6 have higher VDEs. Additionally, natural population analysis charges show that there is the lowest Δq (0.14) for the C7 and C9 atoms. We hope that our theoretical results may provide a reference for further experiment and practical
application. 相似文献
12.
Jyoti Chattopadhyaya Alexander Dömling Klaus Lorenz Wolfgang Richter Ivar Ugi Birgit Wener 《Nucleosides, nucleotides & nucleic acids》2013,32(5-6):843-848
Abstract Various new one-pot multicomponent reactions (MCRs) of CII and PIII derivatives and their libraries are described here. The preparation of some nucleobase- and phospholipid compound libraries by MCRs have been carried out. 相似文献
13.
14.
ABSTRACT Capsule: Fitting geolocators to Common Sandpipers Actitis hypoleucos did not affect their return rates, return dates, body condition or reproductive success, but did cause leg injuries in some individuals. Aims: To investigate the effect of fitting geolocators to Common Sandpipers on their return rates and timing, the condition in which they return and their subsequent breeding success. Methods: We fitted geolocators to colour-ringed Common Sandpipers and monitored them throughout the breeding seasons prior to migration and following return from their wintering grounds. We then compared return rate, return date, change in body condition, hatching success, and fledging success between birds with and without the tags. We also fitted a number of smaller geolocators to wintering individuals in Africa and compared their return rates with a control group. Results: We found no significant differences between birds with and without geolocators in any of the variables measured. However, several individuals fitted with the larger tags were found to have incurred leg injuries. Conclusion: Our study highlights the need for complete transparency when reporting the effects of geolocators and shows the importance of continuous monitoring of individuals when carrying out tracking studies. 相似文献
15.
《Plains anthropologist》2013,58(56):85-90
AbstractRecent cutbacks in research funding and the burgeoning population of anthropology graduate departments may soon force cultural anthropologists to recognize what their archaeological colleagues have long known: their own “backyard” is a field for fertile research. Specifically, cultural anthropologists may turn increasingly to using long-neglected data sources - rich in documentation - on Anglo-Saxon America. This paper briefly investigates some reasons for the study of American historical data and presents a preliminary analysis of some data. 相似文献
16.
Phytosterols of marine algae: Insights into the potential health benefits and molecular pharmacology
《Phytomedicine》2020
BackgroundMarine algae are rich in some unique biologically active secondary metabolites having diverse pharmacological benefits. Of these, sterols comprise a group of functional lipid compounds that have attracted much attention to natural product scientists.PurposeThis review was aimed to update information on the health effects of algae-derived phytosterols and their molecular interactions in various aspects of human health and diseases and to address some future perspectives that may open up a new dimension of pharmacological potentials of algal sterols.MethodsA literature-based search was carried out to retrieve published research information on the potential health effects of algal phytosterols with their pharmacological mechanisms from accessible online databases, such as Pubmed, Google Scholar, Web of Science, and Scopus, using the key search terms of ‘marine algae sterol’ and ‘health potentials such as antioxidant or anti-inflammatory or anti-Alzheimer's or anti-obesity or cholesterol homeostasis or hepatoprotective, antiproliferative, etc.’ResultsPhytosterols of marine algae, particularly fucosterol, have been investigated for a plethora of health benefits, including anti-diabetes, anti-obesity, anti-Alzheimer's, antiaging, anticancer, and hepatoprotection, among many others, which are attributed to their antioxidant, anti-inflammatory, immunomodulatory and cholesterol-lowering properties, indicating their potentiality as therapeutic leads. These sterols interact with enzymes and various other proteins that are actively participating in different cellular pathways, including antioxidant defense system, apoptosis and cell survival, metabolism, and homeostasis.ConclusionIn this review, we briefly overview the chemistry, pharmacokinetics, and distribution of algal sterols, and provide critical insights into their potential health effects and the underlying pharmacological mechanisms, beyond the well-known cholesterol-lowering paradigm. 相似文献
17.
Martin Macouzet Benjamin K. Simpson Byong H. Lee 《Critical reviews in biotechnology》2013,33(3):179-196
ABSTRACT:?Fish metabolism needs special enzymes that have maximum activity at very different conditions than their mammalian counterparts. Due to the differences in activity, these enzymes, especially cold-adapted proteases, could be used advantageously for the production of some foods. In addition to the enzymes, this review describes some other unique fish polypeptides such as antifreeze proteins, fluorescent proteins, antitumor peptides, antibiotics, and hormones, that have already been cloned and used in food processing, genetic engineering, medicine, and aquaculture. Recombinant DNA technology, which allows these biological molecules to be cloned and overexpressed in microorganisms is also described, highlighting innovative applications. The expected impact of cloning fish proteins in different fields of technology is discussed. 相似文献
18.
Süreyya Ölgen Zuhal Kiliç Ahmet O. Ada Tulay Çoban 《Journal of enzyme inhibition and medicinal chemistry》2013,28(4):457-462
We have previously reported on the synthesis of novel indole derivatives where some compounds showed significant antioxidant activity. Here, we report the synthesis of novel N–H and N-substituted indole-2- and 3-carboxamide derivatives and investigated their antioxidant role in order to identify structural characteristics responsible for activity. Although all compounds showed a strong inhibitory (95–100%) effect on superoxide anion (SOD) only compounds 4, 5 and 6 showed simliar potency for the inhibition of lipid peroxidation (81–94%) which revealed that compounds 4, 5 and 6 possessed highly potent antioxidant properties. Substitution in the 1-position of the indole ring caused the significant differences between the activity results regarding lipid peroxidation inhibition. 相似文献
19.
Mohamed F. Abdel-Megeed Mohamed A. Saleh Youssef L. Aly Ibrahim M. Abdo 《Nucleosides, nucleotides & nucleic acids》2013,32(9-10):1985-1996
Abstract A series of some new acetylated S-glycosides of 2-thioxoquinazolin-4-ones, their thiono analogues and 3,1-benzothazin-2,4-dithione derivatives, including a D-glucose and a D-galactose derivatives and a D-xylose, and an L-arabinose derivatives have been synthesized. The conformation and configuration of these carbohydrate derivatives were determined by analysing their 1H and 13C NMR chemical shifts and coupling constants. The biological activity of these compounds has been studied. 相似文献
20.
G. Gosselin M. C. Bergogne J. L. Imbach J. De Rudder E. De Clercq 《Nucleosides, nucleotides & nucleic acids》2013,32(1-2):65-72
Abstract The α-and β-D-Xylofuranosyl and -lyxofuranosyl analogues of the five naturally occurring nucleic acid bases have been the subject of a systematic synthesis and examination of some of their biological properties, i.e. antiviral, antimetabolic and cytostatic activities. 相似文献