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Regulation of transcriptional initiation in yeast mitochondria 总被引:3,自引:0,他引:3
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Tandem promoters direct E. coli ribosomal RNA synthesis. 总被引:46,自引:0,他引:46
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Transcription products from the rplKAJL-rpoBC gene cluster 总被引:12,自引:0,他引:12
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Wagner R 《Journal of molecular microbiology and biotechnology》2002,4(3):331-340
The global regulatory nucleotides (p)ppGpp are major effectors for the control of ribosomal RNA in bacteria. The effector molecules accumulate to different cellular levels at amino acid deprivation or during different growth rates. They change the activity of RNA polymerase to transcribe from sensitive promoters (e.g. ribosomal RNA promoters). Sensitive promoters are characterized by a GC-rich discriminator element in addition to further structural requirements not completely understood. ppGpp must also be regarded as a mediator for growth rate control although it appears that ppGpp-independent regulatory mechanisms exist. Inhibition occurs at various steps during initiation but also during elongation where RNA polymerase pausing is observed. From the existing data a mechanistic model for the action of ppGpp is suggested considering structural details of RNA polymerase obtained at high resolution. 相似文献
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Nucleotide sequence of the gene for ribosomal protein S20 and its flanking regions 总被引:24,自引:0,他引:24
G A Mackie 《The Journal of biological chemistry》1981,256(15):8177-8182
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