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Juan Yang Jing Wang Li Pan Huirong Li Chunbao Rao Xiaobo Zhang Guozhen Niu Jia Qu Ling Hou 《Experimental cell research》2014
Although the differentiation of melanoblasts to melanocytes is known to depend on many distinct factors, it is still poorly understood which factors lead to the induction of melanoblasts. To determine which factors might induce melanoblasts, we examined a set of candidate factors for their ability to induce expression of MITF, a master regulator of melanoblast development, in an ES cell-based melanocyte differentiation system. It appears that BMP4 is capable of inducing MITF expression in stem cells. In contrast, a number of other factors normally implicated in the development of the melanocyte lineage, including WNT1, WNT3a, SCF, EDN3, IGF1, PDGF, and RA, cannot induce MITF expression. Nevertheless, BMP4 alone does not allow MITF-expressing precursors to become differentiated melanocytes, but the addition of EDN3 further promotes differentiation of the precursors into mature melanocytes. Our results support a model in which BMP4 induces MITF expression in pluripotent stem cells and EDN3 subsequently promotes differentiation of these MITF expressing cells along the melanocyte lineage. 相似文献
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Hypoxia-inducible factor 1{alpha} is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells
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Buscà R Berra E Gaggioli C Khaled M Bille K Marchetti B Thyss R Fitsialos G Larribère L Bertolotto C Virolle T Barbry P Pouysségur J Ponzio G Ballotti R 《The Journal of cell biology》2005,170(1):49-59
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Julia C. Cronin John Wunderlich Stacie K. Loftus Todd D. Prickett Xiaomu Wei Katie Ridd Swapna Vemula Allison S. Burrell Neena S. Agrawal Jimmy C. Lin Carolyn E. Banister Phillip Buckhaults Steven A. Rosenberg Boris C. Bastian William J. Pavan Yardena Samuels 《Pigment cell & melanoma research》2009,22(4):435-444