提高《生物工程设备》课程教学质量的探索与实践

《生物工程设备》是生物工程专业本科生的学科专业课程。针对《生物工程设备》课程的教学现状,本着调整课程教学体系、优化教学内容、革新教学方法和手段、重视实践教学基地建设和师资队伍建设、注重培养学生创新能力等形式和原则, 对课程进行了教学改革和实践。     

提高《生物工程设备》课程教学质量的探索与实践

《生物工程设备》是生物工程专业本科生的学科专业课程。针对《生物工程设备》课程的教学现状,本着调整课程教学体系、优化教学内容、革新教学方法和手段、重视实践教学基地建设和师资队伍建设、注重培养学生创新能力等形式和原则,对课程进行了教学改革和实践。     

“生物工程设备”国家一流本科课程建设与实践

生物技术产业是我国战略新兴产业,近年来发展极为迅速,对实践创新型人才需求极大。作为生物工程专业核心课程,“生物工程设备”在生物技术产业实践创新型人才培养中具有重要意义。本课程针对当前课程教学中的设备可及性低、工程实训机会少和学生学习缺乏主动性等痛点,以设备资源和素材库建设、虚实结合工程实训、学生学习积极性调动为抓手,构建“育德、育智、育能(实践创新能力)、对接社会发展新需求、融入学科前沿新进展、引入科研实践新成果(三育三新)”教学内容,创新教学方式和优化考核评价,通过课内外联动-校内外联动、引入前沿进展及科研成果、多样化资源集成、线上线下结合等手段,提高学生的主动性和创新能力,以达到“三会一能”。通过教学探索和实践,提高了课程教学的有效性,学生实践创新能力显著提升。     

热烈庆祝镇江东方生物工程设备技术公司成立10周年！

东方生物工程公司经过十年的不断发展，已经取得了相当的成就，在这里我们感谢各位用户对我们的信任和支持!祝愿我们的朋友们鹏程万里，与我们携手走向更美好的明天。     

生物工程专业酶工程网络课程运行模式的实践与探索

酶工程网络课程建设是生物工程专业教学模式改革的重要部分,通过网络平台可将学生与授课教师有机结合,同时能更好地整合教学资源,提高学习效果,优化学习结构,为学生多媒体教学后的复习与知识拓展、疑难问题的及时解决创造了良好的条件。因此,为了进一步提高网络课程的建设质量,需优化课程设计体系,突出网络学习优点,并紧密结合学科发展前沿和本院教师科研方向,以促进网络课程的应用及实践。     

生物工程专业课程群的改革探索

在对本校生物工程专业人才培养过程中发现的问题入手,对专业课程群建设的现状进行分析,对于优化课程体系以及相关教学内容的有效衔接、强化学生工程实践能力培养等方面提出了相应的改革思路,以期提高本专业的办学水平。     

生物工程专业微生物学教学改革与实践

针对生物工程专业微生物学理论教学与实验教学如何围绕学生工程能力和创新能力的培养组织教学进行探讨,从教材选定,教学内容重组与更新,培养学生的科学精神和综合思考能力,注重理论联系实际以及教学方法、教学手段、实验考核制度的改革等进行了一些有益的尝试,取得了较为满意的效果。     

生物工程专业发酵课程群建设探索

针对生物工程专业的培养方案和就业方向,提出了以课程群建设推动专业发展的教学改革思路。以"生物工艺学"和"生物反应工程"为主干课,还包括"生物工程设备"、"代谢控制与发酵"、"生物过程检测与控制"等相关课程,同时结合"发酵工艺实验"、"生产实习"和"毕业设计"等实践教学环节,构建了发酵课程群。介绍了发酵课程群对教学内容的整合,分析了课堂教学与实践环节有机结合的教学模式。实践证实,发酵课程群的建设对学生的就业以及后续工作能力的提升起到了显著的促进作用。     

生物工程专业实验教学改革与实践

从生物工程专业实验的课程设置、实验内容、教学方式、考核方式以及为学生提供实验平台等方面进行改革及实践,提升了实验教学质量,提高了学生的整体素质,培养了学生的创新精神,为学生进一步深造或就业奠定了坚实基础。     

生物工程设备课程教学模式的改革

对生物工程设备专业课程的现状进行了分析,并对专业课课堂教学模式进行了改革,探索出一种新的专业课课堂教学模式。     

基于神经网络的生化过程预估优化控制

综观历史与现状,生化过程数学模型的建立是很困难的。不多的一些数学模型也往往由于精度低,应用范围窄而无法在实际中应用。这是由于生化过程的机理非常复杂,具有高度非线性和时变特性。并且不同于一般物理过程的是生化过程是个物理上不可逆的过程。近几年来,人工神经网络(ANN)得到了迅速发展,并被广泛应用到各个领域。同样,ANN也为生化过程控制提供了一种新方法。本文以工业生产中发酵过程的补料控制为例,叙述了ANN如何用干生化过程预估和优化控制。相应地,对结果进行了分析讨论。     

Bioprocess intensification: a potential aqueous two-phase process for the primary recovery of B-phycoerythrin from Porphyridium cruentum

A process for the primary recovery of B-phycoerythrin from Porphyridium cruentum exploiting aqueous two-phase systems (ATPS) was developed in order to reduce the number of unit operations and benefit from an increased yield of the protein product. The evaluation of system parameters such as poly(ethylene glycol) (PEG) molecular mass, concentration of PEG as well as salt, system pH and volume ratio was carried out to determine under which conditions the B-phycoerythrin and contaminants concentrate to opposite phases. PEG 1450-phosphate ATPS proved to be suitable for the recovery of B-phycoerythrin because the target protein concentrated to the top phase whilst the protein contaminants and cell debris concentrated in the bottom phase. An extraction ATPS stage comprising volume ratio (Vr) equal to 1.0, PEG 1450 24.9% (w/w), phosphate 12.6% (w/w) and system pH of 8.0 allowed B-phycoerythrin recovery with a purity of 2.9 (estimated as the relation of the 545-280 nm absorbances). The use of ATPS resulted in a primary recovery process that produced a protein purity of 2.9 +/- 0.2 and an overall product yield of 77.0% (w/w). The results reported demonstrated the practical implementation of ATPS for the design of a primary recovery process as a first step for the commercial purification of B-phycoerythrin produced by P. cruentum.     

Bioprocess design: Study of a case

We developed a scale-up process design for the production of the 18 kDa heat shock recombinant protein from Mycobacterium leprae cloned in Saccharomyces cerevisiae (1). Here we present some of the costs associated with running a process based in our laboratory and pilot scale data. Based on these values and assuming the demand of the 18kDa-hsp protein as 500g/year we can review costs at least on an approximate basis.     

Bioprocess engineering: now and beyond 2000

Abstract: Bioprocess engineering may be defined as the translation of life-science discoveries into practical products, processes, or systems capable of serving the needs of society. It is a critical link from discovery to commercialization. Current bioprocess engineering is primarily focused on biopharmaceutical products of high dollar value per gram such as erythropoietin or growth hormones. However, other products of current interest include ethanol, amino acids, organic acids, antibiotics, and specialty chemicals. Current challenges for increased use of bioprocesses for producing bulk and semi-bulk chemicals include both technical and infrastructural barriers. Technical barriers are easy to identify and at times can be overcome by engineering improvements or changes brought about radical developments in science (e.g. recombinant DNA). Infrastructural barriers, such as raw-material substitutions or educational limitations are more difficult to define and change. Recently the National Academy of Sciences examined barriers to bioprocess engineering and issued a report entitled: "Putting Biotechnology to Work: Bioprocess Engineering". A key recommendation was the establishment of a coordinated long-range plan of research, development, training and education in bioprocess engineering involving participation by industry, academe and the federal government. The report was the first national analysis devoted entirely to bioprocess engineering and covered new topics such as space bioprocess engineering. Other topics covered by the author include the current state of the US chemical industry and future directions in three promising areas of bioprocess engineering environmental bioprocess engineering, marine bioprocess engineering and microsystem bioprocess engineering.     

医药类高等院校生物物理课程建设的思考

医用生物物理学是研究生命物质的物理性质,生命过程的物理和物理化学规律以及物理因素对生物系统作用机制的科学,是物理学和生物学相结合而产生的一门边缘学科。在促进物理学和生命科学进步方面都显现出强大的生命力和推动力。基于医用生物物理学发展和我校学科建设发展的现实需要,本文讨论了我校建设医用生物物理学必修课或者选修课的必要性,并从本课程和学校学生特点两个方面考虑,对该课程建设的内容进行了初步的整合。旨在对教学内容进行整合、优化,增加一些新概念、新知识及前沿动态,把新旧知识联系到了一起,教会学生如何应用基础知识解决问题的方法以及缓解目前学时少、内容多这一矛盾。     

军校五年制学员营养学PBL教学模式的构建及效果评价

目的:探讨PBL教学模式在营养学教学中的作用及不足,并评价其教学效果。方法:采用随机抽样的方法,选取第四军医大学2012级五年制营养学专业学员(114名)实施PBL教学,2011级五年制临床专业学员(159名)实施传统教学;从四个方面(考试成绩、教学满意度、学员解决未知问题的方式、学习兴趣及积极性)综合评价PBL教学效果。结果:与传统教学组相比较,PBL教学组的考试成绩、教学满意度、学员解决未知问题的方式以及学习兴趣均显著升高。结论:PBL教学模式不仅提高了学员的考试成绩,还提高了学员的学习能力与素质,有必要进一步优化并大力推广。     

发酵工艺学课程教学改革探讨

根据学科建设及专业发展的需要,结合发酵工艺学课程的教学实践对如何改革该课程的教学内容、教学方法及实践内容进行了初步探讨。     

Data Mining for Bioprocess Optimization

Although developed for completely different applications, the great technological potential of data analysis methods called “data mining” has increasingly been realized as a method for efficiently analyzing potentials for optimization and for troubleshooting within many application areas of process, technology. This paper presents the successful application of data mining methods for the optimization of a fermentation process, and discusses diverse characteristics of data mining for biological processes. For the optimization of biological processes a huge amount of possibly relevant process parameters exist. Those input variables can be parameters from devices as well as process control parameters. The main challenge of such optimizations is to robustly identify relevant combinations of parameters among a huge amount of process parameters. For the underlying process we found with the application of data mining methods, that the moment a special carbohydrate component is added has a strong impact on the formation of secondary components. The yield could also be increased by using 2 m³ fermentors instead of 1 m³ fermentors.     

四阶段四层次医学实验动物学教学模式的建立

通过基础理论、实验操作、应用实践和在职培训四个阶段学习,构建医学特色突出,符合国家法规的医学实验动物学课程体系.针对不同学科专业的培养要求,以及教学对象的素质结构,合理调整教学内容,区别对待研究生、本科生、医学实验专业技术学生和实验动物学专业学员的实验动学教学,制订四层次教学重点与大纲,强化实验动物学与医学生物学的融合,突出专业特点.