共查询到20条相似文献,搜索用时 31 毫秒
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Erika Varkonyi-Gasic Nick Gould Manoharie Sandanayaka Paul Sutherland Robin M MacDiarmid 《BMC plant biology》2010,10(1):159
Background
Plant microRNAs (miRNAs) are a class of small, non-coding RNAs that play an important role in development and environmental responses. Hundreds of plant miRNAs have been identified to date, mainly from the model species for which there are available genome sequences. The current challenge is to characterise miRNAs from plant species with agricultural and horticultural importance, to aid our understanding of important regulatory mechanisms in crop species and enable improvement of crops and rootstocks. 相似文献4.
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Background
Pollen development in flowering plants requires strict control of the gene expression program and genetic information stability by mechanisms possibly including the miRNA pathway. However, our understanding of the miRNA pathway in pollen development remains limited, and the dynamic profile of miRNAs in developing pollen is unknown. 相似文献10.
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Zheng Li Chao Jiang Xingye Li William K.K. Wu Xi Chen Shibai Zhu Chanhua Ye Matthew T.V. Chan Wenwei Qian 《Cell proliferation》2018,51(1)
Objectives
Steroid‐induced osteonecrosis of the femoral head (ONFH) is a common orthopaedic disease of which early detection remains clinically challenging. Accumulating evidences indicated that circulating microRNAs (miRNAs) plays vital roles in the development of several bone diseases. However, the association between circulating miRNAs and steroid‐induced ONFH remains elusive.Materials and methods
miRNA microarray was performed to identify the differentially abundant miRNAs in the serums of systemic lupus erythematosus (SLE) patients with steroid‐induced ONFH as compared with SLE control and healthy control group. We predicted the potential functions of these differentially abundant miRNAs using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses and reconstructed the regulatory networks of miRNA‐mRNA interactions.Results
Our data indicated that there were 11 differentially abundant miRNAs (2 upregulated and 9 downregulated) between SLE‐ONFH group and healthy control group and 42 differentially abundant miRNAs (14 upregulated and 28 downregulated) between SLE‐ONFH group and SLE control group. We also predicted the potential functions of these differentially abundant miRNAs using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses and reconstructed the regulatory networks of miRNA‐mRNA interactions.Conclusions
These findings corroborated the idea that circulating miRNAs play significant roles in the development of ONFH and may serve as diagnostic markers and therapeutic targets. 相似文献13.
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Edyta Koscianska Vesselin Baev Konstantinia Skreka Katerina Oikonomaki Ventsislav Rusinov Martin Tabler Kriton Kalantidis 《BMC molecular biology》2007,8(1):79
Background
MicroRNAs (miRNAs) are one of the most abundant groups of regulatory genes in multicellular organisms, playing important roles in many fundamental cellular processes. More than four hundred miRNAs have been identified in humans and the deregulation of miRNA expression has been also shown in many cancers. Despite the postulated involvement of miRNAs in tumourigenesis, there are only a few examples where an oncogene or a tumour suppressor has been identified as a miRNA target. 相似文献16.
Alain?Sewer Nicodème?Paul Pablo?Landgraf Alexei?Aravin Sébastien?Pfeffer Michael?J?Brownstein Thomas?Tuschl Erik?van Nimwegen Mihaela?Zavolan
Background
MicroRNAs (miRNAs) are endogenous 21 to 23-nucleotide RNA molecules that regulate protein-coding gene expression in plants and animals via the RNA interference pathway. Hundreds of them have been identified in the last five years and very recent works indicate that their total number is still larger. Therefore miRNAs gene discovery remains an important aspect of understanding this new and still widely unknown regulation mechanism. Bioinformatics approaches have proved to be very useful toward this goal by guiding the experimental investigations. 相似文献17.
Mingming Xin Yu Wang Yingyin Yao Chaojie Xie Huiru Peng Zhongfu Ni Qixin Sun 《BMC plant biology》2010,10(1):123
Background
MicroRNAs (miRNAs) are a class of small non-coding regulatory RNAs that regulate gene expression by guiding target mRNA cleavage or translational inhibition. MiRNAs can have large-scale regulatory effects on development and stress response in plants. 相似文献18.
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Stephen F Madden Susan B Carpenter Ian B Jeffery Harry Björkbacka Katherine A Fitzgerald Luke A O'Neill Desmond G Higgins 《BMC bioinformatics》2010,11(1):257