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During the past five years, 127 newborn infants with marked anoxia, severe cardiac failure or respiratory problems secondary to a cardiac lesion were operated upon at l''Hôpital Ste-Justine, Montreal, Quebec.Infants in cardiorespiratory distress from a cardiac lesion for which the surgical treatment is well established, such as complicated coarctation of the aorta, were either cured or improved in 78% of cases. The fatal outcome following medical treatment of patients suffering from lesions for which the surgical treatment is not yet well established, e.g. interruption of the aortic arch, led us to operate upon these infants with the hope of salvaging some of them despite the high surgical risk.The decision to operate was usually based on clinical grounds; however, cine-angiocardiography was at times required to establish the exact diagnosis. Light anesthesia was essential to the success of the operation. Postoperative care was facilitated by a team of nurses well experienced in the treatment of newborn subjects with heart lesions. Fluids were administered in a minimum quantity of 700 c.c./m.2 for 24 hours, and potassium was the only electrolyte added to the replacement fluids. Respiratory problems were reduced to a minimum by active physiotherapy. However, intubation with aspiration of tracheobronchial secretions was carried out when necessary. 相似文献
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S. Carreau 《Andrologie》2000,10(2):141-147
Aromatase is the terminal enzyme responsible for estrogen biosynthesis. Besides somatic cells, the aromatase gene expression and its transduction in a fully active protein in germ cells of rodent testes in one hand, the widespread distribution of estrogen receptors (ERα and ERβ) in the genital tract of the male in an other hand, are clearly in favour of a physiological role for estrogens in the regulation of mammalian testicular functions. In mouse and man, the aromatase deficiency is associated with severe bone maturation problems and sterility. Therefore, together with gonadotrophins and androgens, estrogens (or the balance androgens/estrogens) likely play a physiological role (either directly or via testicular somatic cells) in maintenance of male gonadal functions and obviously, several steps are concerned especially the spermatid production (both in terms of quality and number) and epididymal sperm maturation. 相似文献
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Sans résumé
Avec planches I et II 相似文献
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Centrally generated signals from premotor areas play a key role in voluntary muscle force perception. Indeed, sensations of effort, rather than sensations of intramuscular tension, make it possible to evaluate the intensity of willed muscle forces. We suggest that the sense of effort is involved in agency, the cognitive process by which one is aware of one’s actions. We argue that effort awareness accompanies each action and is the key component of the feeling of will. In delusions of alien control, patients with schizophrenia do not recognize some of their acts as their own and are convinced that they are under the control of someone else. Some experimental data suggest that delusions of control are related to an altered awareness of effort and an exaggerated awareness of afferent neural information, caused by neurological disorders in the frontal and parietal lobes. This impairment could lead to the inability to identify the author of an action. In this pathological condition, the cerebral state coding for “I intend to act” might move toward the state coding for “someone else intends to act”, even in the absence of another agent. 相似文献
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M. Auroux 《Andrologie》1995,5(4):465-475
Up to now, studies concerning the progeny of males undergoing chemotherapy have been difficult to interpret because of their heterogeneity and conflicting nature. Morever, the long term follow up of children has not been carried out. Experimental studies carried out with the cytostatic drug cyclophosphamide have shown that if mating of male rats takes place during the treatment, the frequency of post-implantation losses and fetal malformations increases. If this mating takes place after a recovery period of one to two seminiferous cycles, there is no malformation but only neonatal deaths, and behavioral disorders in adult progeny including diminished learning capacity. These abnormalities are inherited and can present the characteristics of dominant autosomic syndromes. Biochemical analyses of the brains of the first and second generation offspring from treated males show a decrease in two biochemical substrates of memory: hippocampal choline acetyltransferase and fronto-parietal cortex norepinephrine. Abnormalities can also present complex genetic rearrangements revealed in the third generation by, amongst other things, increases in weight gain. Finally, the experimental results suggest that genetic repair may be possible with time. These data and the uncertainty concerning the consequences of chemotherapy in males should systematically lead to: - the cryopreservation of sperm before any mutagenic treatment; - a minimum of two years contraception from the end of treatment; - the long term follow up of children born from treated fathers. 相似文献
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S. M. Gueye S. N. Diop P. A. Fall E. K. Dagadou M. O. C. Abdallahi M. Ba A. Mensah 《Andrologie》1999,9(4):515-518
Objective
To assess the etiological factors of erectile dysfunction in male diabetics.Material and methods
We have performed a prospective evaluation including 69 diabetic patients suffering from erectile dysfunction. Studied parameters including age, type and duration of diabetes, complications, treatments and associated risk factors were analysed. Comparison was done with a control group of 138 diabetic patients without erectile dysfunction.Results
There was a significant difference between the diabetic with neurologic complications and the others without neuropathy (p=0.0004). The duration of the diabete was was another risk factor of erectile dysfunction (p=0.049)Conclusion
We confirm various authors who demonstrated that diabetic impotence seems to be mainly neuropathic in etiology even though it was a multifactorial discomfort. 相似文献10.
《Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie》1998,321(6):501-508
We test herein the hypothesis that the succession of low tides — during which biomass increases — and high tides — during which biomass decreases — controls the dynamic behaviour of the microphytobenthic compartment. Results indeed show that during a complete lunar cycle (14 d) biomass exhibits a series of oscillations due to biomass increases during low tides and decreases during high tides. Moreover, the datasets show that the production level is in the range of previously recorded values and they indicate that the major part of the photosynthetically produced biomass during low tide can be exported into the water column during high tide. This clearly suggests that microphytobenthos is the major autochtonous source of organic matter production in the littoral zone and that it directly supplies the associated pelagic trophic web. 相似文献
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AimTo assess the role of [18F]FDG-PET in solitary plasmacytoma with regards to staging, therapeutic follow-up and monitoring.Patients and methodsTwenty consecutive patients were included in the present study when following conditions were met: (i) solitary plasmacytoma histologically confirmed (bone, n = 16; extramedullary, n = 4); (ii) [18F]FDG-PET scan from July 2004 to April 2009. The clinical follow-up was over than 2 years for 13 patients. Ten patients underwent a post-therapy PET scan. PET scans were visually analysed.ResultsPET scan enabled confirmation of all main lesions (sensitivity: 100%) and also detected infra-clinical lesions in eight cases. Follow-up for more than 2 years showed a progression disease into myeloma in five from six cases (83%) with infraclinical lesions at the baseline PET scan. Among 10 patients who underwent post-therapeutic PET scan, six experienced a complete response at the main lesion site and four experienced a partial response.ConclusionFDG-PET may play an important role in plasmacytoma staging and enables detection of smaller lesions (otherwise undetected). 相似文献
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《Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie》1997,320(5):393-398
Prions are responsible for spongiform diseases such as scrapie and bovine spongiform encephalopathy. It is now generally accepted that the disease mechanism involves the conversion from the normal form, PrPC, to the pathogenic form, PrPSc, and that this isoform is infectious. In the case of scrapie, 15 different forms of the disease have been described and some of these different phenotypes can be conferred by infectious prions that are themselves encoded by normal genes. We propose here that a prion with an altered structure has a correspondingly altered preference for lipids; this altered preference creates a proteolipid domain containing different lipids and other factors such as chaperonins and enzymes responsible for post-translational modifications. Normal prions associated with this abnormal domain adopt the conformation dictated by its lipidic composition (and by the other factors present) and so acquire the lipidic preference of the original pathogenic prions. These transformed prions could then create new proteolipid domains. This process may be considered as semi-conservative replication in which prion and lipids are analogous to the Watson and Crick strands and the proteolipid domain to the double helix itself. 相似文献
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B. Diao M. R. Sy B. Fall Y. Sow A. Sarr S. Mohamed B. Sine P. A. Fall A. K. Ndoye M. Ba B. A. Diagne 《Andrologie》2012,22(1):29-35
Introduction
Male responsibility in couple infertility has been established in several studies. The purpose of this research was to report varicocele clinical and spermatic aspects and assess the outcomes of open retroperitoneal varicocelectomy.Patients and methods
Our study is a retrospective assessment of the outcomes of open retroperitoneal varicocelectomy at the urology department of Aristide Le Dantec teaching hospital (Senegal). Our focus is on patients with varicocelectomy facing couple infertility (inability for sexually active couples who are not using contraceptive methods to obtain a pregnancy over a year), patients among which no other infertility cause was revealed in their partner or partners in polygamist households. To assess the results, we compared the averages of preoperative and postoperative spermatic parameters by using the Z test (comparison test of two averages on two mated series). A difference was regarded as significant if P ?? 0.05.Results
Five hundred and fourteen cases were examined over 6 years (January 2005?CDecember 2010). The average age of the patients was 36.5 ± 7.3 years. The infertility was primary in 62.4%. The analysis of the preoperative spermograms revealed that severe oligozoospermia (33.7%) was the most common abnormalities in the sperm cells concentrations. The abnormalities in the sperm cells concentrations were variously connected with an asthenozoospermia and to a theratozoospermia. The patients were monitored with an average hindsight of 22 months (6?C48 months). The improvement of the parameters was more significant on the concentration and the mobility of sperm cells. The natural pregnancy rate obtained in our study was 20.8%. The registered pregnancies were more important in the group IV (48%). No case of natural pregnancy was noted in the group I but an induction of the spermatogenesis was noted in 20.5% of the cases. About two thirds of natural pregnancies (64%) were noted during the first 12 post-operative months.Conclusion
The surgical treatment of varicocele allows improving the spermatic parameters. Not only do these improvements help obtain natural pregnancies but also simplify the techniques of ART planned with the preoperative spermatic parameters. 相似文献14.
《Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie》1997,320(3):259-266
Four survival curves of plant parasitic nematodes are analysed with Teissier's model. The model is based upon the assumption of an exponential decrease with time of the life expectancy, E(t) = E0 exp(−αt), with E0 the life expectancy at time 0 and α a decay coefficient. By integrating this formula we obtain an expression for the number of survivors at time t, S(t), as a function of the time, t, and S0, the number of individuals at time 0, and the parameters E0 and α: S(t) = S0exp[αt −(exp(αt) −1)/αE0. S0 is a scaling parameter, related to the initial number of individuals in the population, thus the form of the curve depends only on the parameters E0 and α, which are readily understandable in a biological model. These parameters E0 and α are estimated by fitting the model to experimental data using a non-linear regression based on a least squares procedure. The results show a highly significant fit of the model to the data indicating the ability of the model to describe the plant parasitic nematodes survival curve. Results are discussed and the hypothesis of Teissier is compared with other related hypotheses. 相似文献
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《L'Anthropologie》2021,125(5):102968
Palaeolithic archaeology in Tohoku region has long been discussed on constructing chronology, however it is difficult to build reliable chronological order because of poor stratigraphic excavations. In recent radiocarbon dating has advanced. In this paper I discuss the relation between chronology and radiocarbon dating in Tohoku region. At first, I categorize the Palaeolithic industries and establish the chronology by analyzing tool typology, lithic technology, and stratigraphic data. I correlate it with radiocarbon data from sites in Tohoku region. The result of analysis shows that Upper Palaeolithic industries are divided into 18 categories and 8 periods on chronology. The calibration curve IntCal 13 indicated that oldest Early Upper Palaeolithic site appeared around 37,000 cal BP, and late Upper Palaeolithic started about 27,000 cal BP. The pottery first appeared as far back as around 16,000 cal BP. Now we do not have enough radiocarbon data, so we have to gather and examine more 14C data. 相似文献
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A. Gomez-Brouchet 《Médecine Nucléaire》2008,32(3):138-141
The diagnosis of a bone infection is sometimes made difficult when clinical signs and imaging are not typical. In these cases, the role of a pathologist is important since he makes the diagnosis and improves the management of the infection. The main histopathological features of a bone infection and its complications, as well as the involvement of a pathologist in this pathology, are described in this article. 相似文献
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