共查询到20条相似文献,搜索用时 31 毫秒
1.
2.
3.
Pavlov V Raedler H Yuan S Leisman S Kwan WH Lalli PN Medof ME Heeger PS 《Journal of immunology (Baltimore, Md. : 1950)》2008,181(7):4580-4589
Decay-accelerating factor (DAF) is a cell surface regulator that accelerates the dissociation of C3/C5 convertases and thereby prevents the amplification of complement activation on self cells. In the context of transplantation, DAF has been thought to primarily regulate antibody-mediated allograft injury, which is in part serum complement-dependent. Based on our previously delineated link between DAF and CD4 T cell responses, we evaluated the effects of donor Daf1 (the murine homolog of human DAF) deficiency on CD8 T cell-mediated cardiac allograft rejection. MHC-disparate Daf1(-/-) allografts were rejected with accelerated kinetics compared with wild-type grafts. The accelerated rejection predominantly tracked with DAF's absence on bone marrow-derived cells in the graft and required allograft production of C3. Transplantation of Daf1(-/-) hearts into wild-type allogeneic hosts augmented the strength of the anti-donor (direct pathway) T cell response, in part through complement-dependent proliferative and pro-survival effects on alloreactive CD8 T cells. The accelerated allograft rejection of Daf1(-/-) hearts occurred in recipients lacking anti-donor Abs. The results reveal that donor DAF expression, by controlling local complement activation on interacting T cell APC partners, regulates the strength of the direct alloreactive CD8(+) T cell response. The findings provide new insights into links between innate and adaptive immunity that could be exploited to limit T cell-mediated injury to an allograft following transplantation. 相似文献
4.
5.
6.
Transcription factor Sp1 binds to and activates a human hsp70 gene promoter. 总被引:7,自引:6,他引:1
下载免费PDF全文
![点击此处可从《Molecular and cellular biology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
W D Morgan 《Molecular and cellular biology》1989,9(9):4099-4104
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
Tone M Powell MJ Tone Y Thompson SA Waldmann H 《Journal of immunology (Baltimore, Md. : 1950)》2000,165(1):286-291