共查询到20条相似文献,搜索用时 750 毫秒
1.
L Chan H Jin T Stefanac W Wang J F Lavallée J Bédard S May 《Bioorganic & medicinal chemistry letters》1999,9(17):2583-2586
Structure-activity relationship studies on our newly identified anti-HCMV compounds, the 1,6-naphthyridines led to the identification of isoquinoline-6-carboxamides as potent and selective anti-HCMV agents. 相似文献
2.
N Nguyen-Ba L Chan M Quimpère N Turcotte N Lee H Mitchell J Bédard 《Nucleosides & nucleotides》1999,18(4-5):821-827
We have developed a novel class of 2-phosphonate 1,3-dioxolane nucleotide analogues, from which the guanine derivative displayed weak anti-HCMV activity. Further SAR studies led to the identification of both cis and trans guanine derivatives of tetrahydrofuran analogues as potent anti-HCMV agents, both in vitro and in vivo, compared to ganciclovir and HPMPC. 相似文献
3.
Paul Nguyen-Ba Nathalie Turcotte Leonard Yuen Jean Bédard Miguel Quimpère Laval Chan 《Bioorganic & medicinal chemistry letters》1998,8(24):113-3566
We have recently described the discovery of new leads in the area of anti-HCMV research. Further structure - activity relationship studies have allowed us to identify potent and selective anti-HCMV nucleotide analogs. The synthesis as well as structure - activity relationship studies are described. 相似文献
4.
N. Nguyen-ba L. Chan M. Quimpère N. Turcotte N. Lee H. Mitchell 《Nucleosides, nucleotides & nucleic acids》2013,32(4-5):821-827
Abstract We have developed a novel class of 2-phosphonate 1,3-dioxolane nucleotide analogues, from which the guanine derivative displayed weak anti-HCMV activity. Further SAR studies led to the identification of both cis and trans guanine derivatives of tetrahydrofuran analogues as potent anti-HCMV agents, both in vitro and in vivo, compared to ganciclovir and HPMPC. 相似文献
5.
Feng-Jung Yang Kai-Hsiang Shu Hung-Yuan Chen I-Yu Chen Fang-Yun Lay Yi-Fang Chuang Chien-Sheng Wu Wan-Chuan Tsai Yu-Sen Peng Shih-Ping Hsu Chih-Kang Chiang George Wang Yen-Ling Chiu 《Immunity & ageing : I & A》2018,15(1):15
Background
Accumulating evidence indicates that persistent human cytomegalovirus (HCMV) infection is associated with several health-related adverse outcomes including atherosclerosis and premature mortality in individuals with normal renal function. Patients with end-stage renal disease (ESRD) exhibit impaired immune function and thus may face higher risk of HCMV-related adverse outcomes. Whether the level of anti-HCMV immune response may be associated with the prognosis of hemodialysis patients is unknown.Results
Among 412 of the immunity in ESRD study (iESRD study) participants, 408 were HCMV seropositive and were analyzed. Compared to 57 healthy individuals, ESRD patients had higher levels of anti-HCMV IgG. In a multivariate-adjusted logistic regression model, the log level of anti-HCMV IgG was independently associated with prevalent coronary artery disease (OR?=?1.93, 95% CI?=?1.2~?3.2, p =?0.01) after adjusting for age, sex, hemoglobin, diabetes, calcium phosphate product and high sensitivity C-reactive protein. Levels of anti-HCMV IgG also positively correlated with both the percentage and absolute number of terminally differentiated CD8+ and CD4+?CD45RA+?CCR7- TEMRA cells, indicating that immunosenescence may participate in the development of coronary artery disease.Conclusion
This is the first study showing that the magnitude of anti-HCMV humoral immune response positively correlates with T cell immunosenescence and coronary artery disease in ESRD patients. The impact of persistent HCMV infection should be further investigated in this special patient population.6.
临床试用大蒜制剂预防和治疗人巨细胞病毒感染取得了明显效果。在此基础上我们应用细胞病变(CPE)抑制试验和空斑抑制试验,对大蒜中的抗人巨细胞病毒成份进行了初步筛选和比较,证实新鲜大蒜中存在多种抗该病毒的有效成份,其中至少包括大蒜新素(二丙烯三硫)和Ajoene类似物。 相似文献
7.
Paul Nguyen-Ba Nola Lee Helen Mitchell Laval Chan Miguel Quimpère 《Bioorganic & medicinal chemistry letters》1998,8(24):3675-3560
A novel class of cyclic nucleotide analogs has shown anti-HCMV activity. The synthesis as well as structure - activity relationship studies are presented. 相似文献
8.
Falardeau G Lachance H St-Pierre A Yannopoulos CG Drouin M Bédard J Chan L 《Bioorganic & medicinal chemistry letters》2005,15(6):1693-1695
A novel class of macrocyclic 1,6-napthyridines designed to adopt the presumed bioactive conformation of anti-HCMV acyclic 1,6-napthyridines are described. Both 14- and 15-membered macrocycles were shown to be highly potent against HCMV HSV-1 and HSV-2. 相似文献
9.
A series of novel fluorocyclopropyl nucleosides were synthesized using the Simmons-Smith reaction as a key reaction starting from 1,3-dihydroxyacetone. All the nucleosides synthesized were assayed against several viruses. Among the compounds synthesized, the 5-fluorouracil analogue 15 showed significant anti-HCMV activity (9.22 microM). 相似文献
10.
Chan L Stefanac T Lavallée JF Jin H Bédard J May S Falardeau G 《Bioorganic & medicinal chemistry letters》2001,11(2):103-105
1,6-Naphthyridine-2-carboxylic acid benzylamides are potent anti-HCMV compounds. Replacement of the amide moiety by other groups containing internal hydrogen bonds was undertaken to extend the SAR. Our results indicated that the urca derivatives showed very good activity. 相似文献
11.
The synthesis of new rigid guanine analogues with anti-HIV-1 and anti-herpes viral activities is described. The phosphonate of difluorocyclopropane nucleoside analogue 26 exhibits in vitro anti-HIV-1 activity similar to that of PMEA in MT-4 cells. Further, analogue 20 shows moderate anti-HCMV activity in MRC cells. 相似文献
12.
Kelleher MR McGuigan C Andrei G Snoeck R De Clercq E Balzarini J 《Nucleosides, nucleotides & nucleic acids》2005,24(5-7):639-641
2'3'-Dideoxy furanopyrimidines were shown to display anti-HCMV activity via a non-nucleoside mechanism. Further studies into highly modified sugar derivatives led to the preparation of N-and O-alkylated C10 furanopyrimidine analogues, and this work is described herein. These compounds were tested against HCMV strains, and the first case of submicromolar activity was observed. 相似文献
13.
Gerona-Navarro G Pérez de Vega MJ García-López MT Andrei G Snoeck R Balzarini J De Clercq E González-Muñiz R 《Bioorganic & medicinal chemistry letters》2004,14(9):2253-2256
Different Phe-derived 1-acyl-beta-lactams, analogous to a series of 2-azetidinones acting as HCMV serine protease inhibitors, were synthesized. Some of these compounds were modest inhibitors of the HCMV replication. Interestingly, removal of the carbonyl group of the beta-lactam ring, most likely acting as the serine trap, resulted in an azetidine derivative with anti-HCMV activity comparable to that of the reference compound ganciclovir. 相似文献
14.
Novel D- and L-2'-azido-2',3'-dideoxyribofuranosyl-4'-thiopyrimidines and purines have been synthesized starting from L-xylose and D-xylose, respectively. Among synthesized compounds tested against several viruses such as HIV-1, HSV-1, HSV-2, and HCMV, D-beta-N6-methyladenine (ent-22a) and D-alpha-N6-methyladenine (ent-22b) analogues were found to exhibit significant anti-HCMV activity. 相似文献
15.
Martinez A Gil C Castro A Pérez C Prieto C Otero J 《Bioorganic & medicinal chemistry》2003,11(11):2395-2402
Two new series of BTD derivatives have been synthesised allowing to explore the steric requirements for their biological activity. The N3-alkylBTD compounds have shown antiviral activity in the same order or lower than previously prepared compounds. However, the cytotoxicity values observed prevent this new series of BTD derivatives from its potential therapeutic application. Concerning BTD derivatives with the modified linker attached to N1 position, we have obtained new non-nucleoside anti-HCMV derivatives. The activity against HCMV is shown at concentrations that were 10-fold lower than the concentration that was toxic for the host cells, which confirm that these derivatives show a specific antiviral effect against HCMV. SAR conclusions derived from these last compounds have provided new knowledge about the structural requirements of BTD showing certain positions that could be modified for enhancing the anti-HCMV action. 相似文献
16.
Hua Li Jin Cheol Yoo Eunae Kim Joon Hee Hong 《Nucleosides, nucleotides & nucleic acids》2013,32(11):945-960
The synthesis of new rigid guanine analogues with anti-HIV-1 and anti-herpes viral activities is described. The phosphonate of difluorocyclopropane nucleoside analogue 26 exhibits in vitro anti-HIV-1 activity similar to that of PMEA in MT-4 cells. Further, analogue 20 shows moderate anti-HCMV activity in MRC cells. 相似文献
17.
18.
Zhaoda Zhang Jean A. Smith Adrienne P. Smyth Warren Eisenberg Alexandra Nichols Gregory S. Pari 《Nucleosides, nucleotides & nucleic acids》2013,32(7-9):1169-1172
Abstract Several thiono triester containing oligonucleotide phosphorothioates linked with a lipophilic group have been synthesized. Some of these modified antisense oligonucleotides show potent anti-HCMV activity as well as improved cellular association and nuclease resistance. 相似文献
19.
A series of novel acyclic nucleosides 10, 11, 21, and 22 were synthesized efficiently starting from D-lactose. The condensation of the mesylate 5 and 16 with an adenine and cytosine base under standard nucleophilic substitution conditions (K2CO3, 18-Crown-6, DMF) afforded a series of acyclic novel nucleosides. Compound 21 displayed moderate anti-HCMV activity in the AD-169 cells (EC50 = 18.5 microg/mL) without exhibiting any cytotoxicity up to 100 microM. 相似文献
20.
Jeong LS Moon HR Hong JH Yoo SJ Choi WJ Kim HO Ahn HS Baek HW Chun MW Kim HD Kim J Choi JR 《Nucleosides, nucleotides & nucleic acids》2001,20(4-7):657-660
Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Apio dideoxydidehydro nucleosides showed moderate to potent anti-HCMV activity, but their bioisosteric thioapio dideoxydidehydro nucleosides did not exhibit any significant antiviral activity. 相似文献