共查询到20条相似文献,搜索用时 140 毫秒
1.
A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levels. 总被引:9,自引:0,他引:9
下载免费PDF全文
![点击此处可从《Journal of virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Guey-Chuen Perng Barak Maguen Ling Jin Kevin R. Mott Nelson Osorio Susan M. Slanina Ada Yukht Homayon Ghiasi Anthony B. Nesburn Melissa Inman Gail Henderson Clinton Jones Steven L. Wechsler 《Journal of virology》2002,76(3):1224-1235
2.
3.
Herpes simplex virus type 1 serum neutralizing antibody titers increase during latency in rabbits latently infected with latency-associated transcript (LAT)-positive but not LAT-negative viruses.
下载免费PDF全文
![点击此处可从《Journal of virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Guey-Chuen Perng Susan M. Slanina Ada Yukht Homayon Ghiasi Anthony B. Nesburn Steven L. Wechsler 《Journal of virology》1999,73(11):9669-9672
4.
5.
Jiang X Chentoufi AA Hsiang C Carpenter D Osorio N BenMohamed L Fraser NW Jones C Wechsler SL 《Journal of virology》2011,85(5):2325-2332
6.
The locus encompassing the latency-associated transcript of herpes simplex virus type 1 interferes with and delays interferon expression in productively infected neuroblastoma cells and trigeminal Ganglia of acutely infected mice
下载免费PDF全文
![点击此处可从《Journal of virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Peng W Henderson G Inman M BenMohamed L Perng GC Wechsler SL Jones C 《Journal of virology》2005,79(10):6162-6171
7.
8.
Three herpes simplex virus type 1 latency-associated transcript mutants with distinct and asymmetric effects on virulence in mice compared with rabbits
下载免费PDF全文
![点击此处可从《Journal of virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Perng GC Esmaili D Slanina SM Yukht A Ghiasi H Osorio N Mott KR Maguen B Jin L Nesburn AB Wechsler SL 《Journal of virology》2001,75(19):9018-9028
9.
10.
11.
12.
13.
14.
A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
下载免费PDF全文
![点击此处可从《Journal of virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Guey-Chuen Perng Susan M. Slanina Ada Yukht Barbara S. Drolet William Keleher Jr. Homayon Ghiasi Anthony B. Nesburn Steven L. Wechsler 《Journal of virology》1999,73(2):920-929
15.
16.
17.
18.
19.
20.
The region of the herpes simplex virus type 1 LAT gene that is colinear with the ICP34.5 gene is not involved in spontaneous reactivation. 总被引:4,自引:3,他引:1
下载免费PDF全文
![点击此处可从《Journal of virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
G C Perng K Chokephaibulkit R L Thompson N M Sawtell S M Slanina H Ghiasi A B Nesburn S L Wechsler 《Journal of virology》1996,70(1):282-291
The goal of this report was to determine if the region of the LAT gene that is colinear with ICP34.5 (kb 6.2 to 7.1 of LAT) is involved in spontaneous reactivation of herpes simplex virus type 1. We inserted one copy of the ICP34.5 gene into the unique long region of a herpes simplex virus type 1 (strain McKrae) mutant lacking both copies of ICP34.5 (one in each viral long repeat) and the corresponding 917-nucleotide colinear portion of LAT (kb 6.2 to 7.1). Rabbits were ocularly infected with this mutant, and spontaneous reactivation relative to that for the wild-type virus and the original mutant was measured. As we previously reported, the original ICP34.5-deleted virus (d34.5) was significantly impaired for spontaneous reactivation and virulence (G. C. Perng, R. L. Thompson, N. M. Sawtell, W. E. Taylor, S. M. Slanina, H. Ghiasi, R. Kaiwar, A. B. Nesburn, and S. L. Wechsler, J. Virol. 69:3033-3041, 1995). In contrast, we report here that restoration of one copy of ICP34.5 at a distant location completely restored the wild-type level of in vivo spontaneous reactivation, despite retention of the deletion in LAT (spontaneous reactivation rate = 0.3 to 1.4% for the ICP34.5 deletion mutant, 7.7 to 19.6% for the wild type, and 9 to 16.1% for virus with one copy of ICP34.5). Thus, the 917-nucleotide region of LAT from kb 6.2 to 7.1 was not involved in the LAT function required for wild-type spontaneous reactivation. We also found that restoration of a single ICP34.5 gene in a novel location did not restore wild-type virulence (rabbit death rate = 0% [0 of 15] for the original ICP34.5 deletion mutant, 8% [2 of 24] for the single-copy IPC34.5 virus, and 52% [14 of 27] for wild-type virus; P < 0.001 for one versus two copies of ICP34.5). It is likely that either two gene doses of ICP34.5 or its location in the long repeat is essential for full functionality of ICP34.5's virulence function. Furthermore, the ability of the single-copy ICP34.5 virus to reactivate at wild-type levels despite being significantly less virulent than wild-type virus separates the spontaneous reactivation phenotype from the virulence phenotype. 相似文献