共查询到20条相似文献,搜索用时 93 毫秒
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Codon identity regulates mRNA stability and translation efficiency during the maternal‐to‐zygotic transition 下载免费PDF全文
Ariel A Bazzini Florencia del Viso Miguel A Moreno‐Mateos Timothy G Johnstone Charles E Vejnar Yidan Qin Jun Yao Mustafa K Khokha Antonio J Giraldez 《The EMBO journal》2016,35(19):2087-2103
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Derivative of plant phenolic compound inhibits the type III secretion system of Dickeya dadantii via HrpX/HrpY two‐component signal transduction and Rsm systems 下载免费PDF全文
Yan Li William Hutchins Xiaogang Wu Cuirong Liang Chengfang Zhang Xiaochen Yuan Devanshi Khokhani Xin Chen Yizhou Che Qi Wang Ching‐Hong Yang 《Molecular Plant Pathology》2015,16(2):150-163
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Post‐translational modification directs nuclear and hyphal tip localization of Candida albicans mRNA‐binding protein Slr1 下载免费PDF全文
Chaiyaboot Ariyachet Christian Beißel Xiang Li Selena Lorrey Olivia Mackenzie Patrick M. Martin Katharine O'Brien Tossapol Pholcharee Sue Sim Heike Krebber Anne E. McBride 《Molecular microbiology》2017,104(3):499-519
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We have previously characterized several fungal‐specific proteins from the human pathogen Candida albicans that either encode subunits of mitochondria Complex I (CI) of the electron transport chain (ETC) or regulate CI activity (Goa1p). Herein, the role of energy production and cell wall gene expression is investigated in the mitochondria mutant goa1Δ. We show that downregulation of cell wall‐encoding genes in the goa1Δ results in sensitivity to cell wall inhibitors such as Congo red and Calcofluor white, reduced phagocytosis by a macrophage cell line, reduced recognition by macrophage receptors, and decreased expression of cytokines such as IL‐6, IL‐10 and IFN‐γ. In spite of the reduced recognition by macrophages, the goa1Δ is still killed to the same extent as control strains. We also demonstrate that expression of the epithelial cell receptors E‐cadherin and EGFR is also reduced in the presence of goa1Δ. Together, our data demonstrate the importance of mitochondria in the expression of cell wall biomolecules and the interaction of C. albicans with innate immune and epithelial cells. Our underlying premise is thatmitochondrial proteins such as Goa1p and other fungal‐specific mitochondrial proteins regulate critical functions in cell growth and in virulence. As such, they remain as valid drug targets for antifungal drug discovery. 相似文献