Prevention of Deep Vein Thrombosis by Intermittent Pneumatic Compression of Calf

A consecutive, randomly allocated, controlled clinical trial of the prophylactic effect of intermittent pneumatic compression of the calf on the incidence of postoperative deep vein thrombosis showed that in patients without malignant disease there was a highly significant reduction in the incidence of thrombosis. In patients with malignant disease the incidence of thrombosis was higher than in those without, and there was no reduction in incidence by the application of intermittent compression. In the absence of malignant disease, severity of operation and the age of the patient were the most significant aetiological factors. We found no relation between the incidence of deep venous thrombosis and obesity, length of preoperative stay, location of hospital, or duration of anaesthesia. We suggest that intermittent pneumatic compression as used in this trial is a safe, effective, and extremely practical method of preventing postoperative deep vein thrombosis in patients not suffering from malignant disease.     

Effect of intravenous dextran 70 and pneumatic leg compression on incidence of postoperative pulmonary embolism.

The incidence of pulmonary embolism and deep vein thrombosis was measured in 50 matched pairs of patients undergoing common surgical procedures with preoperative and postoperative ventilation-perfusion lung scans and the fibrinogen uptake test. One patient in each pair was treated with intravenous dextran 70 and pneumatic leggings. The incidence of pulmonary embolism among the treated patients was significantly reduced from 24% to 8%, but the incidence of deep vein thrombosis was not significantly reduced (34% to 24%).     

Dextran-related complications in head and neck microsurgery: do the benefits outweigh the risks? A prospective randomized analysis

Increased experience with free-tissue transfer has minimized flap loss secondary to microvascular thrombosis, yet pharmacologic antithrombotic prophylaxis continues to be used routinely. Currently there is no consensus on the ideal pharmacologic agent, dosing, or efficacy. Low-molecular-weight dextran has been widely used for prophylaxis due to its properties of volume expansion and enhanced microrheology. Significant systemic morbidity (pulmonary morbidity, cardiac morbidity, anaphylaxis) is known to occur with use of low-molecular-weight dextran. The purpose of this study was to evaluate morbidity associated with postoperative low-molecular-weight dextran and aspirin prophylaxis in head and neck microsurgery patients. This study was a randomized prospective analysis of 100 consecutive patients undergoing microvascular reconstruction for head and neck malignancy during a 2-year period. Patients were randomized into one of three postoperative antithrombotic prophylaxis treatment groups: low-molecular-weight dextran 20 cc/hour for 48 hours (n = 35), low-molecular-weight dextran 20 cc/hour for 120 hours (n = 32), or aspirin 325 mg/day for 120 hours (n = 27). Six patients were excluded intraoperatively due to the need for systemic heparin therapy. Treatment groups were compared for age, sex, prior medical problems, duration of anesthesia, and intraoperative fluid intake. Flap outcome and the incidence of local and systemic complications were evaluated in the treatment groups. Patient ages ranged from 12 to 84 years (mean age, 58 years). No significant difference was found among the treatment groups with respect to age, sex, prior medical problems, duration of anesthesia, intraoperative fluid intake, and the distribution of donor and recipient sites. There were no total flap losses and two partial flap losses in this series. Three flaps were reexplored and all were salvaged. The incidence of systemic complications (congestive heart failure, myocardial infarction, pulmonary edema, pleural effusion, and pneumonia) was as follows: low-molecular-weight dextran 120 hours, 51 percent; low-molecular-weight dextran 48 hours, 29 percent; and aspirin, 7 percent. Analysis of these data suggests that the method of prophylaxis had no effect on overall flap survival. However, the incidence of systemic complications was significantly related to the method of prophylaxis, with patients receiving low-molecular-weight dextran 120 hours and 48 hours at a 7.2 and 3.9 times greater relative risk, respectively, of developing a systemic complication compared with patients receiving aspirin. The results of this study have eliminated the routine use of low-molecular-weight dextran prophylaxis at our institution in an effort to reduce morbidity in head and neck microsurgical reconstruction.     

间歇性充气加压疗法对下肢深静脉血栓患者血液流变学的影响

目的：观察间歇性充气加压疗法（intermittent pneumatic compression,IPC）对下肢深静脉血栓形成（deep vein thrombosis oflower limbs,DVT）患者的治疗效果,并从血液流变学方面探讨间歇性充气加压的作用机理。方法：2003年3月-2010年9月我科收治的243例下肢深静脉血栓患者,将其中42例IPC治疗病例定为B组实验组,145例单纯药物治疗病例中选取60例定为A组对照组。观察两组患者血液流变学指标和小腿肿胀消退情况的对比。结果：两组患者全血粘度、红细胞聚集指数、红细胞电泳时间、红细胞变形性,在治疗第1天较入院时无差异,组间无差异（P〉0.05）,第3天较入院时有差异（P〈0.05）,组间第3天有差异（P〈0.05）,两组患者下肢肿胀度均明显消退,但B组肿胀消退速度明显快于对照组（P〈0.05）。结论：间歇性充气加压治疗仪可有效改变血液流变学状态,改善血液高凝状态,有效缓解肢体肿胀症状,缩短住院时间。且不增加治疗难度,使用简单,治疗依从性好。     

Dextran 70 in prophylaxis of thromboembolic disease after surgery: a clinically oriented randomized double-blind trial.

A randomized double-blind trial of prophylaxis of thromboembolism in surgical patients judged by clinical morbidity has been completed. Altogether 831 patients over 40 years of age who underwent elective surgery of the stomach, biliary system, or colon received either dextran 70 or normal saline before the operation. Thirteen of the 435 patients on saline and three of the 396 on dextran developed pulmonary embolism. Eight of these 16 patients died of pulmonary embolism--seven in the saline group and one in the dextran group. As detected either clinically or by 125I-fibrinogen scanning the incidence of deep vein thrombosis was similar in the two groups. There was no increased incidence of excessive bleeding in patients on dextran though clinical impression suggested that some patients on dextran bled excessively. This trial showed that dextran 70 administered by intravenous drip during operation is effective in preventing pulmonary embolism and, in particular, reducing mortality from this cause. It seems to be as effective as subcutaneous heparin but is easier to administer and places less of a burden on nursing services.     

Comparison of aerosol ipratropium bromide and salbutamol in chronic bronchitis and asthma.

The effects of inhaling 200 mu g of salbutamol were compared with those of inhaling 40 mu g of ipratropium bromide singly and in combination with salbutamol in eight patients with bronchitis and eight asthmatic patients in a double-blind controlled trial. Changes in airways resistance were assessed by measuring the forced expiratory volume in 1 second and specific airways conductance. Both drugs were significantly better in relieving airways obstruction than placebo. Salbutamol was significantly more effective than ipratropium bromide in patients with asthma, but in the patients with bronchitis there was no significant difference between salbutamol and ipratropium bromide. The combination of the two drugs produced a slightly greater and longer response than either drug alone but this was not significant.     

Incidences of fatal postoperative pulmonary embolism after prophylaxis with dextran 70 and low-dose heparin: an international multicentre study.

A total of 4352 patients were admitted to a prospective'' randomised multicentre trial comparing the prophylactic efficacy of dextran 70 and low-dose heparin against fatal pulmonary embolism after elective operations for general, orthopaedic, urological, and gynaecological conditions. Out of 3984 patients correctly admitted, 1993 were allocated to receive dextran 70 and 1991 to receive low-dose heparin. Withdrawal of prophylaxis because of bleeding or technical difficulties occurred more often in the heparin group, but allergic reactions were more common in the dextran group. Of the 75 patients who died within 30 days after operation, 38 had been given dextran and 37 low-dose heparin. Necropsy was performed in 33 and 32 of these cases respectively. In six patients in each group pulmonary embolism was the sole or a contributory cause of death. Of these, five patients in the dextran group and two in the heparin group had received a full course of prophylaxis. There was no statistically significant difference between the two treatment groups in the incidence of fatal pulmonary embolism after a full course of prophylaxis.     

Mechanisms of blood flow during pneumatic vest cardiopulmonary resuscitation

Mechanisms of blood flow during cardiopulmonary resuscitation (CPR) were studied in a canine model with implanted mitral and aortic flow probes and by use of cineangiography. Intrathoracic pressure (ITP) fluctuations were induced by a circumferential pneumatic vest, with and without simultaneous ventilation, and by use of positive-pressure ventilation alone. Vascular volume and compression rate were altered with each CPR mode. Antegrade mitral flow was interpreted as left ventricular (LV) inflow, and antegrade aortic flow was interpreted as LV outflow. The pneumatic vest was expected to elevate ITP uniformly and thus produce simultaneous LV inflow and LV outflow throughout compression. This pattern, the passive conduit of "thoracic pump" physiology, was unequivocally demonstrated only during ITP elevation with positive-pressure ventilation alone at slow rates. During vest CPR, LV outflow started promptly with the onset of compression, whereas LV inflow was delayed. At compression rates of 50 times/min and normal vascular filling pressures, the delay was sufficiently long that all LV filling occurred with release of compression. This is the pattern that would be expected with direct LV compression or "cardiac pump" physiology. During the early part of the compression phase, catheter tip transducer LV and left atrial pressure measurements demonstrated gradients necessitating mitral valve closure, while cineangiography showed dye droplets moving from the large pulmonary veins retrograde to the small pulmonary veins. When the compression rate was reduced and/or when intravascular pressures were raised with volume infusion, LV inflow was observed at some point during the compressive phase. Thus, under these conditions, features of both thoracic pump and cardiac pump physiology occurred within the same compression. Our findings are not explained by the conventional conceptions of either thoracic pump or cardiac compression CPR mechanisms alone.     

Deep venous thrombosis and pulmonary embolus after face lift: a study of incidence and prophylaxis

Deep venous thrombosis and pulmonary embolus are known risks of surgery. However, the incidence of these conditions in face lift is unknown. In this study, the incidence of deep venous thrombosis/pulmonary embolus after face lift is studied and factors associated with thromboembolic complications are evaluated. One-third of the active members of the American Society for Aesthetic Plastic Surgery were randomly selected. Participating surgeons completed a one-page survey providing information on face-lift procedures during a 12-month study period. A response rate of 80 percent was achieved, with 273 of the 342 surgeons responding to the survey. A total of 9937 face-lift procedures were reported in the 1-year study period. There were 35 patients with deep venous thrombosis (0.35 percent), 14 patients with pulmonary embolus (0.14 percent), and 1 patient death in the series. Although 43.5 percent of patients underwent face lift under general anesthesia, 83.7 percent of deep venous thrombosis/pulmonary embolus events occurred with general anesthesia. For prophylaxis for deep venous thrombosis/pulmonary embolus, 19.7 percent of the surgeons used intermittent compression devices, 19.6 percent used thromboembolic disease hose or Ace wraps, and 60.7 percent used no prophylaxis. Of patients developing deep venous thrombosis/pulmonary embolus, 4.1 percent were treated prophylactically with intermittent compression devices, 36.7 percent with thromboembolic disease hose/Ace wraps, and 59.2 percent with no prophylaxis. It was found that deep venous thrombosis/pulmonary embolus after face lift is a measurable complication experienced by one of nine surgeons surveyed. Deep venous thrombosis/pulmonary embolus is more likely to occur when the procedure is performed under general anesthesia. The majority of plastic surgeons surveyed used no prophylaxis for deep venous thrombosis when performing face-lift procedures. Intermittent compression devices were associated with significantly fewer thromboembolic complications, whereas Ace wrap/thromboembolic disease hose afforded no protection against deep venous thrombosis/pulmonary embolus when used alone. In conclusion, aesthetic surgeons should consider adopting intermittent compression devices when performing face lift under general anesthesia.     

输尿管镜钬激光碎石术与气压弹道碎石术治疗下段输尿管结石的临床疗效分析

目的:探讨输尿管镜钬激光碎石术与气压弹道碎石术治疗下段输尿管结石的临床疗效。方法:选取146例输尿管下段结石患者,将所有患者随机分为试验组和治疗组两组,其中试验组患者均采取输尿管镜钬激光碎石术进行治疗,而对照组患者则采取气压弹道碎石术进行治疗,比较两组患者手术前后的血清肌酐(Serum creatinine,Sc R)和血尿素氮(Blood urea nitrogen,BUN)等手术指标。结果:对照组患者完成手术所需要的时间和住院时间以及血尿时间均明显长于试验组患者,对照组患者之中的碎石成功率为71.91%(105例),明显低于试验组患者的碎石成功率84.25%(123例),两组患者之间的数据比较均有统计学意义(均P0.05)。两组患者手术之前的BUN和Sc R水平均无明显差异,而在手术之后两组患者的BUN和Sc R水平均显著降低,并且试验组患者的降低幅度明显大于对照组患者(均P0.05)。试验组患者在术后一个月时的结石排净率为94.52%,明显高于对照组患者的83.56%(P0.05);试验组患者的并发症发生率为3.42%,明显低于对照组患者的13.01%(P0.05);并且试验组患者的止痛药使用比例为20.00,明显低于对照组患者的34.62(均P0.05)。结论:输尿管镜钬激光碎石术在治疗输尿管下段结石方面效果显著,且具有安全性高和创伤小以及恢复速度快等优势。     

Importance of hypovolaemic shock and endoscopic signs in predicting recurrent haemorrhage from peptic ulceration: a prospective evaluation.

The incidence of rebleeding was studied prospectively in 177 patients with acute gastrointestinal haemorrhage from peptic ulceration with reference to the degree of haemodynamic insult on admission and the presence of endoscopic signs of recent haemorrhage on initial endoscopy. Rebleeding occurred in two (2%) of 114 patients without shock, in seven (18%) of 38 with tachycardia (pulse rate greater than 100 beats/min, systolic blood pressure greater than 100 mm Hg), and in 12 (48%) of 25 with shock (systolic blood pressure less than 100 mm Hg). A similar gradient was noted with the presence of endoscopic signs alone. Rebleeding occurred in four (5%) of 79 patients with no endoscopic signs, in none of 40 with black spot only, in 11 (23%) of 48 with a clot, and in five (50%) of 10 with a visible vessel on endoscopy. When the incidence of rebleeding was assessed in shocked patients, however, it was significantly higher in those with important signs (clot or visible vessel), in 11 (79%) out of 14 patients, than in those with no signs, in one (9%) out of 11 (p less than 0.001). These data suggest that the association of shock with important endoscopic signs is a stronger predictor of rebleeding than either shock or important signs alone. More aggressive treatment may be warranted in this small group of patients.     

Cost-effectiveness of primary and secondary prevention of fatal pulmonary embolism in high-risk surgical patients.

Because death due to pulmonary embolism is relatively rare following general surgery, many question the need for prophylaxis. In addition, there has been reluctance to apply new interventions whose cost-effectiveness has not been adequately evaluated. A cost-effectiveness analysis based on over 1000 high-risk patients undergoing abdominothoracic surgery, with effectiveness measured in terms of numbers of deaths from pulmonary embolism averted, has shown subcutaneous administration of heparin in low doses starting 2 hours before the operation to be the most cost-effective of several active approaches to prophylaxis. It averted seven of the eight deaths expected without active prophylaxis per 1000 such patients and cost half as much as the traditional approach of intervening only when venous thromboembolism becomes clinically apparent. Intravenous administration of dextran, although effective, was expensive, and leg scanning with iodine-125-labelled fibrinogen was extremely expensive. Intermittent pneumatic compression of the legs was inexpensive, but, as with leg scanning, its effectiveness has not been determined in randomized trials.     

Prevention of Early Postoperative Deep Vein Thrombosis by Intermittent Compression of the Leg during Surgery

A clinical trial is described in which the effect of intermittent compression of the lower limb during surgery on the incidence of early postoperative deep vein thrombosis was assessed. Deep vein thromboses were diagnosed by the ¹²⁵I-fibrinogen uptake test. Peroperative intermittent compression was achieved by means of an inflatable plastic splint coupled to a pneumatic controller. By compressing only one leg of each patient, each patient acted as his own control.With a sequential statistical analysis, 39 patients were required to pass the 5% level of significance. Eleven thrombi were detected in the control (uncompressed) legs and two occurred in the compressed legs; one of the latter was bilateral. The investigation shows that increasing the pulsatility of the venous flow in the leg is a potent prophylactic against postoperative deep vein thrombosis.     

围手术期介入治疗对伽玛刀治疗肝癌肝硬化临床疗效及预后的影响

目的:探究围手术期介入治疗对伽玛刀治疗肝癌肝硬化临床疗效及预后的影响。方法:选取2013年1月～2015年1月在我院就诊的肝癌肝硬化患者共61例,按照随机数字表法分为对照组(30例)和观察组(31例),对照组患者仅进行伽玛刀治疗,观察组患者进行围手术期介入治疗联合伽玛刀治疗,比较两组患者治疗后的总有效率、治疗后1年和3年的生存率以及不良反应的发生情况。结果:观察组患者治疗后总有效率为77.4%,显著高于对照组(53.3%,P0.05);观察组治疗后1年和3年生存率分别为74.2%、45.2%,均显著高于对照组(53.3%、20.0%,P0.05);两组患者治疗后均发生不同程度的不良反应,但经对症治疗均有效好转,两组不良反应发生率比较差异无统计学意义(P0.05)。结论:围手术期介入治疗联合伽玛刀治疗肝癌患者可以有效提高治疗的总有效率以及治疗后1年和3年的生存率,且安全性好。     

蓝科肤宁联合胶原贴敷料治疗颜面再发性皮炎的临床观察

目的:探讨蓝科肤宁联合胶原贴敷料治疗颜面再发性皮炎的疗效和安全性。方法:将90例入选的颜面再发性皮炎的患者随机分成治疗组、对照1组和对照2组,每组各30例。治疗组给予蓝科肤宁湿敷,早晚各一次,同时给予胶原贴敷料每晚1次,连用4周;对照1组外用蓝科肤宁湿敷;对照2组外用胶原贴敷料每晚1次,连用4周。治疗结束后4周,观察和比较各组患者的主观症状感觉、皮损情况及不良反应的发生情况。结果:所有患者均按要求完成整个疗程。治疗4周后,三组患者的症状评分均显著低于治疗前,且治疗组的症状评分显著低于对照2组(P0.001),而与对照1组比较差异无统计学意义(P0.05)。治疗组、对照1组和对照2组的临床有效率分别为93%、90%、63%,治疗组、对照1组均显著高于对照2组(P0.05),而治疗组和对照1组之间比较差异无统计学意义(P0.05)。三组不良反应的发生率比较均无统计学差异(P0.05)。结论:蓝科肤宁联合胶原贴敷料治疗颜面再发性皮炎的疗效更好,安全性高。     

Osmotic compression and stiffness changes in relaxed skinned cardiac myocytes in PVP-40 and dextran T-500.

Sarcomere lengths, cell widths, indices of stiffness, and striation pattern uniformity were determined from radially compressed isolated adult cardiac myocytes from the rat. Single cells were bathed in a series of relaxing solutions containing 0-15% concentrations of nonpenetrating long chain polymers PVP-40 and dextran T-500. There were no significant changes observed in average sarcomere lengths or in striation pattern uniformity at any concentration. But cell widths decreased and stiffness increased in both polymers in a concentration-osmotic pressure-dependent relationship. Changes in cell width and stiffness were repeatable in either polymer, but only after an initial compression with a 10 or 15% concentration solution. The observed reduction in cell width after initial compression correlates well with known myofilament lattice spacing compression in rat cardiac muscle and is qualitatively similar to compressions seen in skeletal muscle preparations. But the cardiac myofilament lattice may not be as compressible as the skeletal lattice. Like skeletal muscle, stiffness exhibits a two-phase relationship where most of the increase occurs at solution osmotic pressures greater than 20 Torr. Finally, the inherently greater passive stiffness-length relationship of cardiac muscle is maintained at higher osmotic pressures such that the passive elastic modulus is strongly length dependent.     

Prevention of venous thromboembolism after total knee replacement by high-dose aspirin or intermittent calf and thigh compression.

A prospective study of patients undergoing total knee replacement was carried out by using a combination of 125I-fibrinogen scanning and phlebography, and showed a high incidence of venous thromboembolic disease (TE). Ventilation-perfusion lung scanning was performed to detect pulmonary emboli in most patients. High doses of aspirin and an intermittent low-pressure pneumatic compression device (IPCD) were effective, even in women, in preventing TE. Low doses of aspirin and placebo were equally ineffective in preventing TE. Lung-scan abnormalities compatible with pulmonary emboli were found in six out of 10 patients with isolated calf-vein thrombi. Conventional tests of platelet function did not predict the development of TE. No significant differences were found between the patients receiving low and high doses of aspirin with respect to the mean template bleeding time or platelet aggregation in response to adenosine diphosphate, collagen, and epinephrine, although these variables were significantly abnormal in the two groups receiving aspirin compared with those treated with placebo and the IPCD. Thus high doses of aspirin and a new low-pressure IPCD were effective in preventing venous TE in patients (predominantly women) undergoing total knee replacement.     

PF方案同步放化疗治疗中晚期宫颈癌的疗效及毒性反应研究

目的：探究PF 方案同步放化疗治疗中晚期宫颈癌患者的疗效和毒性反应。方法：回顾性分析我院在2014 年6 月～2015 年6 月期间收治的ⅡB～Ⅲ期宫颈癌患者,共152 例,根据治疗方法将其分为单纯放疗组和同步放化疗组,比较两组患者治疗的疗效 和毒性反应。结果：单纯放疗组和同步放化疗组近期疗效总有效率无显著差异,差异不具有统计学意义(P>0.05),但分别对ⅡB 和 Ⅲ期患者进行分析,Ⅲ期患者同步放疗组总有效率显著高于单纯放疗组,差异具有统计学意义(P<0.05);同步放化疗组患者治疗 后骨髓抑制白细胞下降和消化道反应发生率显著高于单纯放疗组,差异具有统计学意义(P<0.05),两组患者皮肤反应的发生情况 比较无显著差异(P>0.05)。结论：PF方案同步放化疗治疗Ⅲ期宫颈癌的临床疗效显著优于单纯放疗治疗,可有效提高近期总有效 率,毒性反应虽较单纯放疗组有所增加,但经临床支持治疗患者均可耐受。     

Tissue fluid pressure and flow during pneumatic compression in lymphedema of lower limbs

Background: Physiotherapy of edema in cases with obstructed main lymphatics of lower limbs requires knowledge of how high external pressures should be applied manually or set in compression devices in order to generate tissue pressures high enough to move tissue fluid to nonswollen regions and to measure its flow rate. Methods: We measured tissue fluid pressure and flow in subcutaneous tissue of lymphedematous limbs stages II to IV at rest and during pneumatic compression under various pressures and inflation timing. An 8-chamber sequential compression device inflated to pressures 50-120?mmHg, for 50 sec each chamber, with no distal deflation, was used. Pressures were measured using a wick-in-needle and electronic manometer. Fluid flow was calculated from continuously recorded changes in limb circumference using strain gauge plethysmography. Results: Before massage, in all stages of lymphedema, stagnant tissue fluid pressures in subcutaneous tissue ranged between -1 and +10 mmHg and did not differ from those measured in normal subjects. Pressures generated in tissue fluid by pneumatic compression reached 40-100 mmHg and were lower than those in inflated chambers. High pressure gradient through the skin was caused by its rigidity (fibrosis) and dissipation of applied compression force to proximal noncompressed limb regions. The calculated volumes of displaced tissue fluid ranged from 10 to 30 ml per compression cycle, to reach in some cases 100 ml in the groin region. Conclusions: Tissue fluid pressures generated by a pneumatic device were found lower than in the compression chambers. The obtained results point to the necessity of applying high pressures and longer compression times to generate effective tissue fluid pressures and to provide enough time for moving the stagnant fluid.     

神经肌肉电刺激联合间歇性充气加压预防颅脑外伤患者下肢深静脉血栓的临床研究

摘要 目的：探讨神经肌肉电刺激（NMES）联合间歇性充气加压预防颅脑外伤患者下肢深静脉血栓（LEDVT）的临床疗效,为预防LEDVT干预措施的选择提供依据。方法：将2020年11月至2021年8月于安徽中医药大学附属六安医院就诊的72例颅脑外伤患者纳入研究对象,随机数字法分为对照组和观察组,各组36例。对照组给予常规措施+间歇性充气加压干预,观察组在对照组基础上联合NMES干预。收集患者资料,比较两组LEDVT情况、卧床时间、住院时间、干预前后凝血功能指标[凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、D-二聚体（D-D）及纤维蛋白原（FIB）]水平、腘静脉、股总静脉血液流速、视觉疼痛模拟量表（VAS）评分,日常生活能力量表（ADL）评分。结果：观察组LEDVT发生率5.56%（2/36）低于对照组25.00%（9/36）,卧床时间、住院时间短于对照组（P＜0.05）;两组干预后凝血功能指标PT、APTT、D-D、FIB水平较干预前显著改善,且观察组较对照组改善更为显著（P＜0.05）;两组干预后腘静脉、股总静脉血液流速、ADL评分较干预前升高,VAS评分较干预前降低,且观察组腘静脉、股总静脉血液流速、ADL评分高于对照组,VAS评分低于对照组（P＜0.05）。结论：NMES联合间歇性充气加压干预能缩短颅脑外伤患者卧床时间和住院时间,改善患者凝血功能和血液循环,减少LEDVT的发生,且有助于减轻患者疼痛,提高患者生活能力。