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Amit Singh Congxin Li Axel C. R. Diernfellner Thomas Hfer Michael Brunner 《PLoS computational biology》2022,18(8)
Eukaryotic circadian clocks are based on self-sustaining, cell-autonomous oscillatory feedback loops that can synchronize with the environment via recurrent stimuli (zeitgebers) such as light. The components of biological clocks and their network interactions are becoming increasingly known, calling for a quantitative understanding of their role for clock function. However, the development of data-driven mathematical clock models has remained limited by the lack of sufficiently accurate data. Here we present a comprehensive model of the circadian clock of Neurospora crassa that describe free-running oscillations in constant darkness and entrainment in light-dark cycles. To parameterize the model, we measured high-resolution time courses of luciferase reporters of morning and evening specific clock genes in WT and a mutant strain. Fitting the model to such comprehensive data allowed estimating parameters governing circadian phase, period length and amplitude, and the response of genes to light cues. Our model suggests that functional maturation of the core clock protein Frequency causes a delay in negative feedback that is critical for generating circadian rhythms. 相似文献
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Hardin PE 《Journal of biological rhythms》2004,19(5):348-360
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Cellular circadian pacemaking and the role of cytosolic rhythms 总被引:3,自引:0,他引:3
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vrille,Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock 总被引:9,自引:0,他引:9
Cyran SA Buchsbaum AM Reddy KL Lin MC Glossop NR Hardin PE Young MW Storti RV Blau J 《Cell》2003,112(3):329-341
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