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1.
《Neurochemical research》2003,28(9):1419-1427
Abstract List
Abstracts of Neirokhimiya, Volume 19, 2002 相似文献2.
Maria F. M. Braga Vassiliki Aroniadou-Anderjaska He Li 《Neurochemical research》2000,25(12):1645-1648
Subject Index
Subject Index for Neurochemical Research, Volume 25, 2000 相似文献3.
Authors Index
Author Index for Neurochemical Research, Volume 26, 2001 相似文献4.
Subject Index
Subject Index for Neurochemical Research, Volume 24, 1999 相似文献5.
H. Akiyama P. L. McGeer S. Itagaki E. G. McGeer T. Kaneko 《Neurochemical research》2002,27(12):1727-1730
Subject Index
Subject Index for Neurochemical Research, Volume 27, 2002 相似文献6.
Author Index
Author Index for Neurochemical Research, Volume 29, 2004 相似文献7.
Subject Index
Subject Index for Neurochemical Research, Volume 26, 2001 相似文献8.
Authors Index
Author Index for Neurochemical Research, Volume 25, 2000 相似文献9.
Authors Index
Author Index for Neurochemical Research, Volume 27, 2002 相似文献10.
Authors Index
Author Index for Neurochemical Research, Volume 24, 1999 相似文献11.
[Purpose]
The purpose of this study was to investigate the effect of unaccustomed downhill running on muscle damage, oxidative stress, and leukocyte apoptosis.[Methods]
Thirteen moderately trained male subjects performed three 40 min treadmill runs at ~70% VO2max on separate days: a level run (L) followed by two downhill runs (DH1 and DH2). Blood samples were taken at rest (PRE) and immediately (POST), 2 h, 24 h, and 48 h after each run. Data were analyzed using 2-way repeated measures ANOVA with post hoc Tukey tests.[Results]
Creatine kinase (CK) activity and oxidative stress level were significantly elevated at 24 h and 48 h following DH1 (P < 0.05). The level of oxidative stress at the POST measurement following DH1 and DH2 was greater than PRE. The rate of leukocyte apoptosis was significantly increased at the POST measurement following all three runs, and remained elevated for up to 48 h following DH1 (P < 0.01).[Conclusion]
CK activity and oxidative stress were elevated following an acute bout of moderate intensity downhill running, resulting in a greater apoptotic response at 24 h and 48 h post-exercise in comparison with level grade running or a second downhill run. These elevations were blunted following DH2. Although the link between exercise-induced muscle damage and leukocyte apoptosis is currently unknown, the differential response to DH1 vs. L and DH2 indicates that it may be mediated by the elevation of oxidative stress. 相似文献12.
《Journal of Aquatic Ecosystem Stress and Recovery (Formerly Journal of Aquatic Ecosystem Health)》2002,9(4):291-292
Volume Contents
Contents, Volume 9 相似文献13.
Daren M. Carlisle 《Journal of Aquatic Ecosystem Stress and Recovery (Formerly Journal of Aquatic Ecosystem Health)》2000,7(4):361-364
Volume Contents
Contents, Volume 7 相似文献14.
Joseph M. Culp Cheryl L. Podemski Kevin J. Cash Richard B. Lowell 《Journal of Aquatic Ecosystem Stress and Recovery (Formerly Journal of Aquatic Ecosystem Health)》2000,7(4):359-360
Authors Index
Author Index, Volume 7 相似文献15.
Andrew J. Rosendale Benjamin N. Philip Richard E. Lee Jr. Jon P. Costanzo 《Biochimica et Biophysica Acta (BBA)/General Subjects》2014
Background
The essential role of glucose transporter 2 (GLUT2) in glucose homeostasis has been extensively studied in mammals; however, little is known about this important protein in lower vertebrates. The freeze-tolerant wood frog (Rana sylvatica), which copiously mobilizes glucose in response to freezing, represents an excellent system for the study of glucose transport in amphibians.Methods
GLUT2 was sequenced from northern and southern phenotypes of R. sylvatica, as well as the freeze-intolerant Rana pipiens. These proteins were expressed and functionally characterized in Xenopus oocytes. Abundance of GLUT2 in tissues was analyzed using immunoblotting techniques.Results
GLUT2s cloned from these anurans encoded proteins with high sequence homologies to known vertebrate GLUT2s and had similar transport properties, although, notably, transport of the glucose analog 3-O-methyl-d-glucose (3-OMG) was strongly inhibited by 150 mM urea. Proteins from all study subjects had similar affinity constants (~ 12 mM) and other kinetic properties; however, GLUT2 abundance in liver was 3.5-fold greater in northern R. sylvatica than in the southern conspecific and R. pipiens.Conclusion
Our results indicate that amphibian GLUT2s are structurally and functionally similar to their homologs in other vertebrates, attesting to the conserved nature of this transport protein. The greater abundance of this protein in the northern phenotype of R. sylvatica suggests that these transporters contribute importantly to freezing survival.General significance
This study provides the first functional characterization of any GLUT isoform from an anuran amphibian and novel insights into the role of these proteins in glucose homeostasis and cryoprotectant mobilization in freeze-tolerant vertebrates. 相似文献16.
Edward B. Rastetter Bonnie L. Kwiatkowski Séverine Le Dizès John E. Hobbie 《Biogeochemistry》2004,69(3):437-438
Volume Contents
Contents Volume 69, 2004 相似文献17.
18.
Introduction
Both canine cutaneous mast cell tumor (MCT) and human systemic mastocytosis (SM) are characterized by abnormal proliferation and accumulation of mast cells in tissues and, frequently, by the presence of activating mutations in the receptor tyrosine kinase V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog (c-KIT), albeit at different incidence (>80% in SM and 10–30% in MCT). In the last few years, it has been discovered that additional mutations in other genes belonging to the methylation system, the splicing machinery and cell signaling, contribute, with c-KIT, to SM pathogenesis and/or phenotype. In the present study, the mutational profile of the Tet methylcytosine dioxygenase 2 (TET2), the isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2), the serine/arginine-rich splicing factor 2 (SRSF2), the splicing factor 3b subunit 1 (SF3B1), the Kirsten rat sarcoma viral oncogene homolog (KRAS) and the neuroblastoma RAS viral oncogene homolog (NRAS), commonly mutated in human myeloid malignancies and mastocytosis, was investigated in canine MCTs.Methods
Using the Sanger sequencing method, a cohort of 75 DNA samples extracted from MCT biopsies already investigated for c-KIT mutations were screened for the “human-like” hot spot mutations of listed genes.Results
No mutations were ever identified except for TET2 even if with low frequency (2.7%). In contrast to what is observed in human TET2 no frame-shift mutations were found in MCT samples.Conclusion
Results obtained in this preliminary study are suggestive of a substantial difference between human SM and canine MCT if we consider some target genes known to be involved in the pathogenesis of human SM. 相似文献19.
Volume Contents
Contents Volume 65, 2003 相似文献20.