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1.
Phytochemical investigation of the roots of Cola rostrata K. Schum. led to the isolation of a new unsaturated fatty acid, named rostratanic acid (1), together with fourteen known compounds, lignoceric acid, friedelan (7), friedelanone (8), bauerenol (3), lupeol (4), herranone (9), acotatarone A (11), betulinic acid (6), betulin (5), nonanedioc acid (2), arjunolic acid (10) stigmasterol, β−sitosterol, and β−sitosterol-3-O-β-D-glucopyranoside. The structure of the new compound as well as those of the known compounds were established by means of spectroscopic methods: NMR analysis (1H and 13C NMR, 1H–1H–COSY, HSQC and HMBC) and high-resolution mass spectrometry (HR-ESI-MS), and by comparison with previously reported data. Two of those known compounds were modified chemically to afford three new derivatives. All those compounds were tested for their cytotoxic activity against the human cervix carcinoma KB-3-1 cells and their antibacterial activity against Escherichia coli, Salmonella enterica, Pseudomonas aeruginosa and Staphylococcus aureus. Although the crude extract gave weak antibacterial activity, none of the isolated compounds showed antibacterial activity, and, only the prenylated derivative showed weak cytotoxicity. In addition, the chemotaxonomic significance of the species Cola rostrata is discussed. 相似文献
2.
The phytochemical and antimicrobial properties of the cones of Cedrus atlantica (Endl) Manetti ex Carrière were investigated. Two new compounds (1,2) and nineteen known compounds (3–21) were isolated. Their structures were established by mass spectrometry (HRESIMS), 1D, 2D NMR and by comparison with literature data. Antimicrobial activity of hydromethanolic extract against a panel of 22 bacteria and yeasts showed an interesting antimicrobial activity. All compound purified from this extract were tested against S. aureus by bioautography. MIC values of the most active compounds were determined using a serial dilution technique. The results showed strong antibacterial activity of the abietane diterpenes 10, 11, 14, 15, 16 and 17. Dehydroabietic acid (17) was the most potent against Enterococcus faecalis (MIC = 15.1 = μg/mL), a multi-resistant commensal bacterium which can cause the fatal infections in humans. 相似文献
3.
The ethyl acetate extract from the whole plant of Crinum biflorum Rottb. Showed a moderate activity against Enterococcus faecalis. Its phytochemical investigation led to the isolation of a new flavan-3-ol derivative namely (2R,3R)-3-hydroxy-7-methoxy-3′,4′-methylenedioxyflavan, together with (2S)-7-hydroxy-3′,4′-methylenedioxyflavan, (2R,3R)-7-methoxy-flavan-3-ol, (2S)-7-hydroxy-3′,4′-dimethoxyflavan, 3′,7-dihydroxy-4′-methoxyflavan, 4′,7-dimethoxy-3′-hydroxyflavan, farrerol, β-sitosterol, β-sitosterol-3-O-β-D-glucopyranoside, oleanolic acid, kaempferol, pancratistatin, lupeol, aurantiamide acetate, Narciprimine and 2,3-dihydroxypropyl palmitate. Their structures were elucidated mainly by extensive spectroscopic analysis and comparison with published data. The absolute configuration of the new metabolite was determined by electronic circular dichroism (ECD) analysis and comparison of optical rotation. Some of the isolated compounds were tested for their antimicrobial activity but no inhibition was observed. 相似文献
4.
Aerial parts of Viguiera linearis afforded 16α-hydroxy-ent-kauranoic acid, viguiestenin, leptocarpin, acetylleptocarpin, budlein B, clovandiol and the new heliangolide 15-hydroxy-acetylerioflorin. 相似文献
5.
W.H.M.Wimalaseela Herath Nimal D.S. Rajasekera M.Uvais S. Sultanbawa G.Percy Wannigama Sinnathamby Balasubramaniam 《Phytochemistry》1978,17(5):1007-1009
From the bark and/or timber extracts of Diospyros hirsuta, D. moonii, D. quaesita, D. spinescens, D. thwaitesii and D. walkeri, the following compounds have been isolated; lupeol, betulin, betulinic acid sitosterol, taraxerol, taraxerone, ursolic acid, oleanolic acid scopoletin, plumbagin, elliptinone, diospyrin and diosindigo A. TLC examination of the bark and timber extract of D. acuta, D. chaetocarpa, D. oblongifolia, D. oppositifolia and D. rheophytica is reported. Lupeol betulin, oleanolic acid and sitosterol have been isolated from the fruit of D. oblongfolia. 相似文献
6.
María C. García-Alvarez Mariapia Paternostro Franco Piozzi Benjamín Rodríguez Giuseppe Savona 《Phytochemistry》1979,18(11):1835-1837
From the aerial parts of Cleonia lusitanica four previously known diterpenoids have been isolated. In addition, a new isopimarane derivative, cleonioic acid, has been obtained and the structure 11α-acetoxy-7,15-iso-pimaradien-18-oic acid established by chemical and spectroscopic means and by correlation with 7,15-isopimaradien-18-ol. 相似文献
7.
A new ferulic acid ester derivative, tetracosane‐1,24‐diyl di[(Z)‐ferulate] ( 1 ), and a new ellagic acid derivative, 3,4 : 3′,4′‐bis(O,O‐methylene)ellagic acid ( 2 ), have been isolated from leaves and twigs of Pachycentria formosana, together with eight known compounds. Their structures were determined by in‐depth spectroscopic and mass‐spectrometric analyses. Among the isolated compounds, oleanolic acid ( 6 ), ursolic acid acetate ( 7 ), and 3‐epibetulinic acid ( 9 ) exhibited potent inhibition (IC50 values ≤21.8 μM ) of O2⋅− generation by human neutrophils in response to N‐formyl‐L ‐methionyl‐L ‐leucyl‐L ‐phenylalanine/cytochalasin B (fMLP/CB). In addition, oleanolic acid ( 6 ), 3‐O‐[(E)‐feruloyl]ursolic acid ( 8 ), 3‐epibetulinic acid ( 9 ), and lawsonic acid ( 10 ) also inhibited fMLP/CB‐induced elastase release with IC50 values ≤18.6 μM . 相似文献
8.
The marine phytoplankton Prorocentrum lima is one of the toxic and harmful microalgae which can cause red tides. In chemical investigation on cultured strain P. lima PL11, seven compounds were isolated and identified by spectroscopic data, including three typical shellfish toxins okadaic acid (OA, 1), OA methyl ester (2), and prorocentrolide (3), three terpenoids (4–6), and one polyketide (7). Compounds 5 and 6 should be derived from carotenoid fucoxanthin. Compounds 4–7 were isolated from this genus of microalgae for the first time. 相似文献
9.
Kozhiparambil K. Purushothaman Ayyappath Sarada Ariyamuthu Saraswathy Joseph D. Connolly 《Phytochemistry》1983,22(4):1042-1043
Sempervirenic acid, a new diterpene has been isolated from Solidago sempervirens and its structure determined by spectroscopic methods and chemical conversions to be 3β-acetoxy-labda-7,13-diene-15-oic acid. 相似文献
10.
In addition to four kaurane and kaurene diterpenes, the stem bark of Xylopia acutiflora yielded a dimeric diterpene derived via Diels-Alder condensation of kaurene and labdane monomers. The structure of the dimer, which has been given the trivial name acutifloric acid, was assigned on the basis of detailed spectroscopic analysis. 相似文献
11.
The investigation of Brickellia paniculata resulted in the isolation of a new diterpene of the labdane type. It was identified as 3α-angeloyloxy- 相似文献
12.
The chemical investigation of the roots of Eremomastax speciosa (Hochst.) Cufod (Acanthaceae). led to the isolation of thirteen compounds including five anthraquinones 1,8-dihydroxy-3-methylanthraquinone (1), 1,8-dihydroxy-3-methoxy-6-methylanthraquinone (2), emodin (3), aloe emodin (4) and 8-O-D-glucopyranosideemodin (5); one phenylethanoid glucoside acteoside (6); one benzophenone 2,6-dimethoxybenzophenone (7); two pentacyclic triterpenoids lupeol (8) and betulinic acid (9); three phytosterols stigmasterol (10), β-sitosterol (11), and β-sitosterol-3-O-β-D-glucopyranoside (12) and one fatty acid hexadecanoid acid (13). All these compounds are firstly reported from the roots of E. speciosa. Emodin and acteoside were modified chemically through allylation reaction to afford 3-O-allylated emodin (3a) and a new perallylated acteoside derivative (6a), respectively. The structure of the isolated compounds as well as those of the allylated derivatives were established by means of spectroscopic methods: NMR analysis (1H and 13C NMR, 1H–1H–COSY, HSQC and HMBC), high-resolution mass spectrometry (HR-ESI-MS) and by comparison with previously reported data. All those compounds were tested for their cytotoxic activity against the human cervix carcinoma KB-3-1 cells and their antioxidant activity, the allylated acteoside derivative and 2,6-dimethoxybenzophenone showed weak cytotoxicity while acteoside showed a good antioxidant activity. In addition, the chemotaxonomic significance of the isolated compound is discussed. 相似文献
13.
Poilaneic acid, a cembranoid diterpene from Croton poilanei, has been characterized as (1R*,2E,4Z,7E, 11Z)-12-carboxyl-1-isopropyl-4,8-dimethylcyclotetradecatetraene. 相似文献
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15.
Hentriacontane, friedelan-3-one, epi-friedelinol, hexacosanol, stigmasterol, a new diterpenic acid and its monomethyl ester are amongst the constituents of Haplopappus foliosus and H. angustifoliosus. The new acid has been called haplopappic acid. 相似文献
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17.
A.A.Leslie Gunatilaka A.M.Y.Jasmin De Silva Subramaniam Sotheeswaran L.M.V. Tillekeratne 《Phytochemistry》1982,21(11):2719-2723
A new lignan, horsfieldin [2-(3-hydroxy-4-methoxyphenyl)-6-(3,4-methylenedioxyphenyl)-3,7-dioxabicyclo(3,3,0)octane], d-asarinin, (?)-dihydrocubebin, dodecanoylphloroglucinol, myristic acid, trimyristin and sitosterol have been isolated and characterized from the hot methanol extract of Horsfieldia iryaghedhi seeds. The absolute configuration of the lignans and the chemotaxonomic significance of their occurrence is discussed. 相似文献
18.
19.
The diterpenoid aldehyde traversianal, a metabolite of the fenugreek pathogen Cercospora traversiana, has been shown to be highly toxic to brine shrimp and snails, and to lyse human red blood cells at concentrations as low as 5 × 10–7 M. The compound also induced betacyanin leakage from beetroot slices but was essentially inactive in other standard tests for phytotoxicity despite its structural similarities to known phytotoxins. It was inactive in the chick bioassay. 相似文献
20.
From the bark of Plumeria obtusifolia was isolated a series of lupeol fatty esters with the carbon numbers 16, 18,20 and 21–28 in the fatty acid part. Furthermore, lupeol, lupeol acetate, sitosterol, stigmasterol and campesterol were also identified. 相似文献