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1.
Mai Kotera 《Inorganica chimica acta》2010,363(13):3602-3605
A reaction of [Cp*IrCl2]2 {Cp* = η5-C5(CH3)5} and 2-mercaptobenzimidazole (H2bimt) in methanol in a 1:2 molar ratio gave a yellow complex of [Cp*IrCl2(H2bimt)]·CH3OH (1). In compound 1 the H2bimt acts as a monodentately S-donating (κS) ligand. A similar reaction of [Cp*IrCl2]2 and H2bimt in the presence of NaOCH3 (molar ratio of 1:2:2) gave an orange product (2) on addition of excess amount of NH4PF6. Compound 2 was composed of an unsymmetrical dinuclear complex cation, [(Cp*IrCl)2(μ-Hbimt)(μ-H2bimt)]+, a PF6− anion, and water molecules of crystallization. In the complex cation, H2bimt bridges two IrIII centers by S atom in the μ-κS:κS mode, while the monodeprotonated Hbimt− ligand bridges via S and N atoms in the μ-κS:κN1 mode. 相似文献
2.
Kenneth Kam-Wing Lo Joe Sai-Wan Chan Vic Wing-Hang Tsang 《Inorganica chimica acta》2004,357(10):3109-3118
We report the synthesis, characterisation, and photophysical and electrochemical properties of a series of luminescent cyclometallated iridium(III) bipyridine-aldehyde complexes [Ir(N-C)2(bpy-CHO)](PF6) (HN-C=2-phenylpyridine, Hppy (1); 2-(4-methylphenyl)pyridine, Hmppy (2); 1-phenylpyrazole, Hppz (3); 3-methyl-1-phenylpyrazole, Hmppz (4); 7,8-benzoquinoline, Hbzq (5); 2-phenylquinoline, Hpq (6); bpy-CHO=4-formyl-4′-methyl-2,2′-bipyridine). The X-ray crystal structures of complexes 1 and 4 have been determined. On the basis of the photophysical data, the emission of these complexes is assigned to an excited state of predominantly triplet metal-to-ligand charge-transfer (3MLCT) (dπ(Ir) → (bpy-CHO)) character. For complex 6, the excited state is also mixed with substantial (3IL) () (pq−) character. The protein bovine serum albumin has been labelled with these complexes to produce luminescent bioconjugates. The photophysical properties of the luminescent conjugates have also been investigated. 相似文献
3.
Takayoshi Suzuki 《Inorganica chimica acta》2006,359(8):2431-2438
A series of new iridium(III) complexes containing pentamethylcyclopentadienyl (Cp∗ = η5-C5Me5) and 1,8-naphthyridine (napy) have been prepared. X-ray crystallography revealed that napy acted as a monodentate, a didentate chelating, and a bridging ligand in complexes of [Cp∗IrCl2(napy)] (1), [Cp∗IrCl(napy)]PF6 (2), and [(Cp∗IrCl)2(H)(napy)]PF6 (4), respectively. The crystal structure of [Cp∗Ir(napy)2](PF6)2 (3) has also been determined; the dicationic complex bore both monodentate and chelating napy ligands. Dinuclear Cp∗IrIII complex bridged by napy was only isolable if two IrIII centers were supported by a hydride (H−) bridge. In complexes 2 and 3, the four-membered chelate rings formed by napy exhibited a large steric strain; in the rings the NIrN bond angles were only 60.5(2)-61.0(4)° and the IrNC angles were 94.7(8)-96.7(8)°. The bridging coordination of napy in complex 4 also afforded a large strain, i.e., the IrIII centers were displaced by 0.84(3) Å from the napy plane, due to the steric interaction between two Cp∗IrCl moieties. The monodentate napy complex 1 in CDCl3 or CD2Cl2 at ambient temperature showed a rapid coordination-site exchange reaction, which gave two N sites of napy equivalent; at temperatures below −40 °C, the 1H NMR spectra corresponded to the molecular structure of [Cp∗IrCl2(napy-κN)]. The analogous diazido complex of [Cp∗Ir(N3)2(napy)] (5) has also been prepared, and the crystal structure has been determined. In contrast to the dichloro complex 1, the diazido complex 5 exhibited a dissociation equilibrium of coordinated napy in solution. 相似文献
4.
Mai Kotera 《Inorganica chimica acta》2008,361(5):1479-1484
The crystal structures of mononuclear (azido)(pentamethylcyclopentadienyl)iridium(III) complexes bearing 2- or 8-quinolinethiolate (n-Sqn−), [Cp∗Ir(N3)(n-Sqn)] {n = 2 (1) or 8 (2); Cp∗ = η5-C5Me5} have been determined by X-ray analysis. The 2-Sqn complex, 1, acquires severe steric strains in the four-membered κ2N,S chelate ring, while the 8-Sqn isomer, 2, forms a strain-free five-membered planar κ2N,S chelate ring. It has also been revealed that the corresponding benzimidazole-2-thiolate (Hbimt−) complex, which was obtained similarly to the above n-Sqn complexes from [Cp∗Ir(N3)2]2 and Na(Hbimt), takes an unsymmetrical dinuclear structure bridged by two Hbimt− ligands with different bonding modes, [Cp∗Ir(N3){μ(S:N1)-Hbimt}{μ(S:S)-Hbimt}Ir(N3)Cp∗] · MeOH (3). 相似文献
5.
Jahar Lal Pratihar Debprasad Patra Surajit Chattopadhyay 《Inorganica chimica acta》2011,367(1):182-186
Reactions of 2-(arylazo)aniline, HL (H represents the dissociable protons upon orthometallation and HL is p-RC6H4NNC6H4-NH2; RH for HL1; CH3 for HL2 and Cl for HL3) with IrCl3 in methanol afforded orthometallated complexes of composition (L)(HL)IrCl2 (2) and (L)(MeOH)IrCl2 (3), respectively. Complex (L)(MeOH)IrCl2 (3) converted into (L)(CH3CN)IrCl2 (4) upon refluxing in acetonitrile. The X-ray structure of the complexes (L1)(HL1)IrCl2 (2a) and (L3)(CH3CN)IrCl2 (4c) have been determined and characterized unequivocally. The anionic L− binds the metal in tridentate (C, N, N) manner for all the complexes. 相似文献
6.
Three binuclear Co(III) complexes with 5,5′-(buta-1,3-diyne-1,4-diyl)bis(3-tert-butylcatechol) (L1), 5,5′-(2,5-dimethoxy-1,4-phenylene)bis(ethyne-2,1-diyl)bis(3-tert-butyl-catechol) (L2) and 5,5′-(4,4′-(buta-1,3-diyne-1,4-diyl)bis(2,5-dimethoxy-4,1-phenylene))bis(ethyne-2,1-diyl)bis(3-tert-butyl-catechol) (L3) have been prepared. The triple bond-containing L1, L2 and L3 ligands were synthesized by a cross-coupling reaction. These complexes were characterized by elemental analyses, electrochemical measurements, 1H NMR and UV-Vis spectra. In [Co2(bpy)4(L1)]2+, electrochemical oxidation of the complexes occurs at the bridges as two closely spaced one-electron couples. UV-Vis spectra reveal that chemical oxidation of [Co2(bpy)4(L1)]2+ using Ag+ occurs as a two-electron process forming [Co2(bpy)4(L1Cat,SQ)]3+ or [Co2(bpy)4(L1SQ,SQ)]4+. On the other hand, [Co2(bpy)4(L2)]2+ and [Co2(bpy)4(L3)]2+ exhibit different oxidation behavior under the same experimental conditions. In this report we discuss the role of the distance between the two metal atoms on the oxidative behavior of binuclear Co(III) complexes. 相似文献
7.
Two novel cobalt(III) mixed-polypyridyl complexes [Co(phen)(2)(dpta)](3+) and [Co(phen)(2)(amtp)](3+) (phen=1,10-phenanthroline, dpta=dipyrido-[3,2-a;2',3'-c]- thien-[3,4-c]azine, amtp=3-amino-1,2,4-triazino[5,6-f]1,10-phenanthroline) have been synthesized and characterized. The interaction of these complexes with calf thymus DNA was investigated by spectroscopic, cyclic voltammetry, and viscosity measurements. Results suggest that the two complexes bind to DNA via an intercalative mode. Moreover, these Co(III) complexes have been found to promote the photocleavage of plasmid DNA pBR322 under irradiation at 365nm. The mechanism studies reveal that hydroxyl radical (OH()) is likely to be the reactive species responsible for the cleavage of plasmid DNA by [Co(phen)(2)(dpta)](3+) and superoxide anion radical (O(2)(-)) acts as the key role in the cleavage reaction of plasmid DNA by [Co(phen)(2)(amtp)](3+). 相似文献
8.
Crisponi G Nurchi VM Pivetta T Gałezowska J Gumienna-Kontecka E Bailly T Burgada R Kozłowski H 《Journal of inorganic biochemistry》2008,102(7):1486-1494
Coordination properties toward Fe(III) and Al(III) of a mixed bisphosphonate-hydroxypyridinonate ligand are presented. Potentiometric, spectrophotometric and NMR results allowed to conclude that Fe(III) and Al(III) coordination takes place on the pyridinone moiety. The high steric hindrance prevents the possibility of simultaneous coordination of both groups to the same metal ion. Quantum mechanical calculations confirm this finding allowing to determine the minimal length of the linker necessary for a stable conformation of complexes in which Fe(III) is coordinated both by pyridinone and bisphosphonate groups. 相似文献
9.
The synthesis of the tris-cyclometalated iridium(III) complex [Ir(DCP)3] (HDCP = 1-(N,N-diphenyl-amino)-4-(4-chlorophenyl)-phthalazine) from hydrated iridium(III) chloride and the ligand HDCP under mild reaction conditions was described. The photophysical, electrochemical and electrophosphorescent properties of this complex were investigated. Organic light-emitting diodes (OLEDs) using the complex as a dopant and a blend of poly(vinylcarbazole) (PVK) with 2-tert-butylphenyl-5-biphenyl-1,3,4-oxadiazol (PBD) as a host exhibited bright red emission at 620 nm with the Commission Internationale de l’Eclairage (CIE) coordinate of (0.67, 0.32). A maximum external quantum efficiency of 13.6% photos/electron with a luminous efficiency of 7.4 cd/A at a current density of 0.73 mA/cm2, and a maximum luminance of 2941 cd/m2 at 99 mA/cm2 were obtained in the device at 4 wt% doping concentration. 相似文献
10.
Two series of complexes of the type [CoIII{(naph)2dien}(amine)]BPh4 {(naph)2dien = bis-(2-hydroxy-1-naphthaldimine)-N-diethylenetriamine dianion, and amine = piperidine (pprdn) (1), pyrrolidine (prldn) (2), pyridine (py) (3), N-methylimidazole (N-MeIm) (4)}, and [CoIII{(naph)2dpt}(amine)]BPh4 {(naph)2dpt = bis-(2-hydroxy-1-naphthaldimine)-N-dipropylenetriamine dianion, and amine = piperidine (pprdn) (5), 3-methylpyridine (3-Mepy) (6)} have been synthesized and characterized by elemental analyses, IR, UV-Vis, and 1H NMR spectroscopy. The crystal structures of (2) and (6) have been determined by X-ray diffraction. The redox potentials of the central cobalt ion show a relatively good correlation with the σ-donor ability of the axial ligands. The spectroscopic and electrochemical properties of these complexes are also influenced by the mutual steric hindrance between the pentadentate Schiff base and the ancillary ligands. 相似文献
11.
Pengfei Shi Qin Jiang Yongmei Zhao Yangmiao Zhang Jun Lin Liping Lin Jian Ding Zijian Guo 《Journal of biological inorganic chemistry》2006,11(6):745-752
Four gold(III) complexes of terpyridine derivatives 1–4 have been synthesized and characterized by spectroscopic methods. In vitro data demonstrated that all of them showed higher cytotoxicity than cisplatin against the human non-small-cell lung cancer cell line (A-549), the human stomach carcinoma cell line (SGC-7901), the human cervix carcinoma cell line (HELA), the human colon carcinoma cell line (HCT-116), the human liver carcinoma cell line (BEL-7402), the murine leukemia cell line (P-388) and the human acute promyelocytic leukemia cell line (HL-60). Complex 3 exhibits the highest activity, with growth inhibition rates of over 80% at 10−8 mol L−1 against the A-549, HCT-116 and HELA tumor cell lines. Interestingly, ligands L1–L4 are also very cytotoxic against the cell lines tested. Complexes 1–4 are stable in aqueous solution for 2 days in the presence of the biological reducing agent glutathione. The inductively coupled plasma mass spectrometry data showed that DNA isolated from cells treated with complexes 1 and 3 contained gold with gold-to-nucleotide ratios of approximately 1:6,400 and 1:4,900, respectively. Fluorescence titration, UV and circular dichroism analyses proved that the steric and electrostatic effects of the ligand remarkably influence the interactions of their gold(III) complexes with DNA. The DNA binding ability of the complexes has been correlated with their cytotoxicity, which could potentially provide a new rationale for the future design of terpyridine-based metal complexes with antitumor potential.Electronic Supplementary Material Supplementary material is available to authorized users in the online version of this article at . 相似文献
12.
Cobalt(III) complexes of diacetyl monooxime benzoyl hydrazone (dmoBH2) and diacetyl monooxime isonicotinoyl hydrazone (dmoInH2) have been synthesized and characterized by elemental analyses and spectroscopic methods. The X-ray crystal structures of the two hydrazone ligands, as well as that of the cobalt(III) complex [CoIII(dmoInH)2]Cl·2H2O, are also reported. It is found that in the cobalt(III) complexes the Co(III) ion is hexa-coordinated, the hydrazone ligands behaving as mono-anionic tridentate O,N,N donors. In the [CoIII(dmoInH)2]Cl·2H2O complex, the amide and the oxime hydrogens are deprotonated for both the ligands, while the isonicotine nitrogens are protonated. In the [CoIII(dmoBH)2]Cl complex, only the amide nitrogens are deprotonated. It is shown that the additional hydrogen bonding capability of the isonicotine nitrogen results in different conformation and supramolecular structure for dmoInH2, compared to dmoBH2, in the solid state. Comparing the structure of the [CoIII(dmoInH)2]Cl·2H2O with that of the Zn(II) complex of the same ligand, reported earlier, it is seen that the metal ion has a profound influence on the supramolecular structure, due to change in geometrical dispositions of the chelate rings. 相似文献
13.
A new one-dimensional manganese(III) Schiff-base complex [Mn(III)(salophen) (MeOTCNQ)] · CH3CN 1 (salophen = N,N′-bis(salicylidene)phenylenediamine) bridged by 7-methoxy-7,7,8,8-tetra-cyano-p-quinodimethane (MeOTCNQ), has been synthesized and characterized by X-ray crystallography and magnetic studies. Crystal structure study reveals that complex 1 has a 1D manganese(III) chain bridged by MeOTCNQ ligand which was obtained unexpectedly from tetracyano-p-quinodimethane (TCNQ) reacting with methanol. Noticeably, MeOTCNQ molecules in complex 1 adopt an unusual cis-syn coordination mode. The analysis of magnetic data indicates that a weak intrachain antiferromagnetic interaction exists in complex 1. 相似文献
14.
Jacewicz D Lapińska A Dabrowska A Figarski A Woźniak M Chmurzyński L 《Analytical biochemistry》2006,350(2):256-262
This study demonstrated the direct formation of the nitrogen dioxide (*NO2) radical during the decomposition of 3-morpholinosydnonimine (SIN-1) in biological buffer 4-morpholinoethanosulfone acid solution. Consequently, at approximately pH 4, SIN-1 can be used successfully as a source of *NO2. This conclusion is drawn from a comparison of the reactions of cis-[Cr(C2O4)(L- L)(OH2)2]+, where L-L denotes pyridoxamine (Hpm) or histamine (hm), with the gaseous *NO2 radical obtained by two methods: from SIN-1 and from a simple redox reaction. These reactions were investigated using the stopped-flow technique. The measurements were carried out at temperatures ranging from 5 to 25 degrees C over a pH range from 6.52 to 9.11 for cis-[Cr(C2O4)(Hpm) (OH2)2]+ and from 6.03 to 8.15 for cis-[Cr(C2O4)(hm)(OH2)2] +. We also determined the thermodynamic activation parameter (E(a)) and the uptake mechanism for each of the coordination compounds studied. 相似文献
15.
Multidrug resistance (MDR) mediated by overexpression of the MDR1 gene product, P-glycoprotein (Pgp), represents one of the best characterized barriers to chemotherapeutic treatment in cancer and may be a pivotal factor in progression of Alzheimer's disease (AD). Thus, agents capable of probing Pgp-mediated transport could be beneficial in biomedical imaging. Herein, we synthesized and structurally characterized a gallium(III) complex (5) of the naphthol-Schiff base ligand. The crystal structure revealed octahedral geometry for the metallodrug. Cytotoxicity profiles of 5 were evaluated in KB-3-1 (Pgp-) and KB-8-5 (Pgp+) human epidermal carcinoma cell lines. Compared with an LC(50) (the half-maximal cytotoxic concentration) value of 1.93 microM in drug-sensitive (Pgp-) cells, the gallium(III) complex 5 demonstrated an LC(50) value>100 microM in drug-resistant (Pgp+) cells, thus indicating that 5 was recognized by the Pgp as its substrate, thereby extruded from the cells and sequestered away from their cytotoxic targets. Radiolabeled analogues of 5 could be beneficial in noninvasive imaging of Pgp-mediated transport in vivo. 相似文献
16.
Two novel paramagnetic octahedral chromium(IV) complexes with dianionic tridentate SNO donor ligands containing extended π-system have been synthesized while only a paramagnetic octahedral chromium(III) complex is obtained when a related dianionic tridentate ONO donor ligand is used under similar conditions. These bischelate complexes [Cr(abtsal)2] (1) (abtsalH2 is the Schiff base of o-aminobenzenethiol and salicylaldehyde), [Cr(4-PhTSCsal)2] · H2O (2) (4-PhTSCsalH2 is the Schiff base of 4-phenylthiosemicarbazide and salicylaldehyde) and K[Cr(sap)2] · H2O (3) (sapH2 is the tridentate Schiff base of salicylaldehyde and o-aminophenol) are characterized by elemental analyses, magnetic moment measurements, IR, UV-Vis and EPR spectroscopic studies. Compound 3 has been structurally characterized by X-ray crystallography. Measured room temperature (RT) magnetic moment values are 2.98 BM for 1 and 2.83 BM for 2 indicating a d2 system with a triplet ground state in both the cases. On the other hand, the magnetic moment value for 3 is found to be 3.74 BM at RT and is consistent with the presence of three unpaired electrons for a d3 Cr(III) ion. The magnetic moment values rule out the large spin-orbit coupling which is substantiated by the presence of RT EPR signals. Compounds 1 and 2 exhibit very similar powder EPR spectra at RT and LNT, which show the allowed transition ΔMs = ±1 (g = 2.004 for both 1 and 2) as well as the “forbidden” half-field transition (ΔMs = ±2) at g = 4.105 for 1 and g = 4.318 for 2, respectively. The X-band LNT frozen glass EPR spectrum of 1 in DMF shows the presence of zero-field split rhombic symmetry character, and results in the parameters g ≅ 2.0, D = 740 G, and E = 260 G. It suggests that the intensity of ΔMs = ±2 forbidden transition is large due to the large D value. The X-band frozen glass EPR spectrum of compound 3 in DMF is found to be very similar to that reported for trans-[Cr(py)4F2]+ in DMF-H2O-MeOH glass. The large difference (∼700 mV) in the reduction potential for the two octahedral complexes 1 (−1.40 V) and 3 (−0.70 V) is attributed to the difference in their metal ion oxidation states. 相似文献
17.
Selvan Nehru Renganathan Arun Kumpati Premkumar 《Journal of biomolecular structure & dynamics》2013,31(11):1876-1888
A new series of pendant-type polymer-cobalt(III) complexes, [Co(LL)2(BPEI)Cl]2+, (where BPEI?=?branched polyethyleneimine, LL?=?dipyrido[3,2-a:2′,3′-c](6,7,8,9-tetrahydro)phenazine (dpqc), dipyrido[3,2-d:2′,3′-f]quinoxaline (dpq) and imidazo[4,5-f]1,10-phenanthroline (ip)) each with three different degrees of coordination have been synthesized and characterized. Studies to know the mode and strength of interaction between these polymer–metal complexes and calf thymus DNA have been performed by UV–Visible absorption and emission techniques. Among these series, each polymer metal complex having higher binding strength with DNA has been selected to test against human cancer/normal cell lines. On the basis of these spectral studies, it is proposed that our polymer–metal complexes bind with DNA mainly through intercalation along with some electrostatic binding. The order of binding strength for the complexes with ligand, dpqc?>?dpq?>?ip. The analysis of the results suggests that polymer–cobalt(III) complexes with higher degree of coordination effectively binds with DNA due to the presence of large number of positively charged cobalt(III) chelates in the polymer chain which cooperatively act to increase the overall binding strength. These polymer–cobalt(III) complexes with hydrophobic ligands around the cobalt(III) metal centre favour the base stacking interactions via intercalation. All the complexes show very good anticancer activities and increasing of binding strength results in higher inhibition value. The polymer–cobalt(III) complex with dpqc ligand possess two fold increased anticancer activity when compared to complexes with other ligands against MCF-7 cells. Besides, the complexes were insensitive towards the growth of normal cells (HEK-293) at the IC50 concentration. 相似文献
18.
Cobalt(III) complexes with potentially tetradentate salophen (H2salophen = N,N′-bis(salicylidene)-1,2-phenylenediamine) as equatorial ligand and with different axial amine ligands (NH3, cyclohexylamine, aniline, 4-picoline and pyridine) were synthesized and characterized by IR, 1H NMR, elemental analysis. Electronic spectra and electrochemical properties of the complexes were studied in DMF solutions. The lowest energy transitions, which occur between 464.8 and 477 nm, are attributed mainly to the intraligand charge transfer, confirmed by Zindo/S electronic structure calculations. The reduction potentials of Co(III)/Co(II) are more affected than those of Co(II)/Co(I) by the axial amine ligands. The crystal structure of the [CoIII(salophen)(4- picoline)2]ClO4 · CH2Cl2 was determined, indicating that the cobalt(III) center is six coordinated surrounded by the tetradentate salophen ligand and two 4-picoline ligands. The crystal packing of the complex shows a layered structure, in which the perchlorate counter ions and also the lattice solvent molecules are intercalated between the bc planes of the complex cations. 相似文献
19.
Jin-Kui Tang Shu-Feng Si Dai-Zheng Liao Zong-Hui Jiang Shi-Ping Yan 《Inorganica chimica acta》2005,358(2):325-330
A novel tetranuclear lanthanide(III)-copper(II) complex of macrocyclic oxamide, [Pr(CuL)3(H2O)2](SCN)3 · 1.5H2O (L = 1,4,8,11-tatraazacyclotradecanne-2,3-dione) (1), has been synthesized, structurally characterized and preliminary investigated by magnetic studies. The structure of the title complex consists of a cationic PrCu3 core, noncoordinated monovalent SCN− anions and H2O molecules; the packing diagram shows open channels formed through intermolecular weak interactions. The temperature-dependent magnetic susceptibilities were analyzed by an approximate treatment being enlightened by Matsumoto et al. leading to J = −1.62 × 10−2 cm−1, Δ = 3.12 cm−1, gCu = 2.13, respectively. 相似文献
20.
Zahra Aramesh-Boroujeni Shohreh Jahani Mozhgan Khorasani-Motlagh Kagan Kerman Nahal Aramesh Saeid Asadpour 《Journal of biomolecular structure & dynamics》2020,38(16):4746-4763
AbstractIn this study, the interactions of a novel metal complex [Dy(bpy)2Cl3.OH2] (bpy is 2,2'-bipyridine) with fish salmon DNA (FS-DNA) and bovine serum albumin (BSA) were investigated by experimental and theoretical methods. All results suggested significant binding between the Dy(III) complex with FS-DNA and BSA. The binding constants (Kb), Stern-Volmer quenching constants (KSV) of Dy(III)-complex with FS-DNA and BSA at various temperatures as well as thermodynamic parameters using Van’t Hoff equation were obtained. The experimental results from absorption, ionic strength, iodide ion quenching, ethidium bromide (EtBr) quenching studies and positive ΔH? and ΔS? suggested that hydrophobic groove-binding mode played a predominant role in the binding of Dy(III)-complex with FS-DNA. Indeed, the molecular docking results for DNA-binding were in agreement with experimental data. Besides, the results found from experimental and molecular modeling indicated that the Dy(III)-complex bound to BSA via Van der Waals interactions. Moreover, the results of competitive tests by phenylbutazone, ibuprofen, and hemin (as a site-I, site-II and site-III markers, respectively) considered that the site-III of BSA is the most possible binding site for Dy(III)-complex. In addition, Dy(III) complex was concurrently screened for its antimicrobial activities. The presented data provide a promising platform for the development of novel metal complexes that target nucleic acids and proteins with antimicrobial activity.Communicated by Ramaswamy H. Sarma 相似文献