蒜氨酸酶的研究

蒜氨酸酶是重要的生理活动物质,能催化蒜氨酸生成蒜素。研究蒜氨酸酶的分离纯化方法、性质及结构．对开发利用大蒜类的药品和保健品有十分重要的意义。     

The effect of insulin on the heart

Positive inotropic effects of insulin were described early after the isolation of insulin from the pancreas but data on the effect of insulin on the heart are conflicting. Systemic insulin administration results in a reduction in circulating free fatty acids and an improvement in myocardial glucose uptake, which causes an efficiency improvement in the myocardial cell. There is strong evidence that insulin administration results in functional improvement in dysfunctional myocardium. (Neth Heart J 2010;18:197-201.)     

The Effect of Phenothiazines on the Electrocardiogram

Thioridazine, chlorpromazine and trifluoperazine were administered to six psychiatric patients. Each was used in four dosage levels (thioridazine and chlorpromazine: 200, 400, 800 and 1200 mg. daily; trifluoperazine: 8, 16, 32, 64 mg. daily); and each increase in dosage was effected after four days of drug administration.Before the trial, twice during each drug period and before commencement of the next dose regimen, an electrocardiogram (ECG) was recorded. The findings indicated that thioridazine modifies the terminal portion (S-T segment, T and U waves) of the human ECG. A similar change occurred in three of six subjects while taking chlorpromazine and in one of six while taking trifluoperazine. Thioridazine induced changes in all six subjects studied, viz., blunting and notching of T waves with or without prolongation of QT interval. In some the notching produced a doublehump appearance in which a T wave of reduced voltage formed the proximal hump and a positive U wave of increased voltage formed the distal hump.Thioridazine-induced alterations in the ECG have been described as resembling those caused by quinidine; they also resemble changes associated with hypokalemia.     

The effect of insulin on the heart

Insulin infusion has been advocated in the treatment of myocardial ischaemia and myocardial infarction. There is evidence from experimental animal studies for a protective effect of high-dose insulin administration in myocardial ischaemia and myocardial infarction. In some relatively small study populations a reduction in mortality was reported in those patients who received glucose-insulin-potassium (GIK) during myocardial infarction, which was confirmed in two meta-analyses. However, it has not been possible to reproduce these positive results in large randomised clinical trials. (Neth Heart J 2010;18:255-9.)     

The genetics of migration on the move

Across a range of organisms, related species or even populations of the same species exhibit strikingly different scales and patterns of movement. A significant proportion of the phenotypic variance in migratory traits is genetic, but the genes involved in shaping these phenotypes are still unknown. Although recent achievements in genomics will evolve migratory genetics research from a phenotypic to a molecular approach, fully sequenced and annotated genomes of migratory species are still lacking. Consequently, many of the genes involved in migration are unavailable as candidates. Migration is central to the life-history adaptations of many animals. Here, we review current understanding of the genetic architecture of migratory traits and discuss the significant implications this will have for other areas of biology, including population responses to climate change, speciation and conservation management.     

高原上的院落

在和马丽华交谈之中,感觉她在自身的不同角色之间游离:面对一个美丽孤绝的高原,她首先是一个充满好奇心与激情的文学来客;而面对文化的西藏,她又成为一个冷静观察、睿智分析的见证人;那么,面对多年来自己生活的现实的西藏,面对这方百姓与热土,她又以自己的方式在关注和影响着周围的生活。