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Whitson RH Tsark W Huang TH Itakura K 《Biochemical and biophysical research communications》2003,312(4):997-1004
Proteins containing the ARID (AT-rich interaction domain) DNA-binding motif regulate gene expression and differentiation in fungi, plants, and animals. This report describes phenotypes resulting from targeted disruption of the ARID gene Mrf-2. Homozygous loss of Mrf-2 resulted in a high rate of neonatal mortality that was partially strain-dependent: survival of Mrf-2(-/-) pups ranged from 6.4% on the 129S1 genetic background to 38% on a mixed 129S1.C57Bl/6J background. Loss of Mrf-2 expression did not affect embryonic survival, embryonic growth or birth weight. Lipid accumulation was severely reduced in brown adipose of Mrf-2(-/-) neonates at 24h of age, however, and Mrf-2(-/-) mice weighed significantly less than controls from postnatal day five onward. Adult Mrf-2(-/-) mice were lean, with significant reductions in brown and white adipose tissues, and in the percentage of body fat. Mrf-2(-/-) and Mrf-2(+/-) mice were also resistant to weight gains and obesity when maintained on high-fat diets. These phenotypes suggest that Mrf-2 is essential for accumulation of lipid stores in postnatal life. 相似文献
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Cell cycle regulation of the T-box transcription factor tbx2 总被引:5,自引:0,他引:5
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Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor 总被引:28,自引:0,他引:28
Naya FJ Black BL Wu H Bassel-Duby R Richardson JA Hill JA Olson EN 《Nature medicine》2002,8(11):1303-1309
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Tadayoshi Hayata Akira Eisaki Hiroki Kuroda M. Asashima 《Development genes and evolution》1999,209(9):560-563
The Xenopus Brachyury-like Xbra3 gene is a novel T-box gene that is closely associated with Xenopus Brachyury. The expression pattern of Xbra3 during development is similar to that of Xbra. During gastrulation Xbra3 is expressed in the marginal zone, with a gradient of increasing expression from ventral to dorsal. In the early neurula stage Xbra3 is expressed in the notochord and posterior mesoderm, but by the tailbud stage its expression is restricted to the forming tailbud and the posterior portion of the notochord. 相似文献
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