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Identification of Arabidopsis genic and non‐genic promoters by paired‐end sequencing of TSS tags
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Mutsutomo Tokizawa Kazutaka Kusunoki Hiroyuki Koyama Atsushi Kurotani Tetsuya Sakurai Yutaka Suzuki Tomoaki Sakamoto Tetsuya Kurata Yoshiharu Y. Yamamoto 《The Plant journal : for cell and molecular biology》2017,90(3):587-605
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Mutual antagonism between DNA methylation and H3K27me3 histone methylation suggests a dynamic crosstalk between these epigenetic marks that could help ensure correct gene expression programmes. Work from Manzo et al ( 2017 ) now shows that an isoform of de novo DNA methyltransferase DNMT3A provides specificity in the system by depositing DNA methylation at adjacent “shores” of hypomethylated bivalent CpG islands (CGI) in mouse embryonic stem cells (mESCs). DNMT3A1‐directed methylation appears to be instructive in maintaining the H3K27me3 profile at the hypomethylated bivalent CGI promoters of developmentally important genes. 相似文献
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