共查询到20条相似文献,搜索用时 0 毫秒
1.
2.
3.
Small RNAs derived from longer non-coding RNAs 总被引:3,自引:0,他引:3
4.
5.
6.
Small non-coding RNAs in animal development 总被引:1,自引:0,他引:1
The modulation of gene expression by small non-coding RNAs is a recently discovered level of gene regulation in animals and plants. In particular, microRNAs (miRNAs) and Piwi-interacting RNAs (piRNAs) have been implicated in various aspects of animal development, such as neuronal, muscle and germline development. During the past year, an improved understanding of the biological functions of small non-coding RNAs has been fostered by the analysis of genetic deletions of individual miRNAs in mammals. These studies show that miRNAs are key regulators of animal development and are potential human disease loci. 相似文献
7.
8.
9.
金黄色葡萄球菌(Staphylococcus aureus,S.aureus)是困扰全球公共卫生及人类健康的重要病原菌,其引起的各种临床感染与该菌表达的多种毒力因子密切相关,而这些毒力因子表达受到调节性因子的精确调控,在细菌致病机制中发挥着核心作用。非编码小RNA(Small non-coding RNA,s RNA)是基因表达的一类重要调节因子,可使细菌对环境因素做出反应,调节其应激适应性及毒力因子表达。但到目前为止,仅少数金黄色葡萄球菌s RNA的生物学功能得到阐述。本文将针对这些调节性s RNA的研究进展作一综述。 相似文献
10.
Small non-coding RNAs as magic bullets 总被引:6,自引:0,他引:6
Eckstein F 《Trends in biochemical sciences》2005,30(8):445-452
11.
12.
13.
14.
Recently, many small non-coding RNAs (sRNAs) with important regulatory roles have been identified in bacteria. As their eukaryotic counterparts, a major class of bacterial trans-encoded sRNAs acts by basepairing with target mRNAs, resulting in changes in translation and stability of the mRNA. RNA interference (RNAi) has become a powerful gene silencing tool in eukaryotes. However, such an effective RNA silencing tool remains to be developed for prokaryotes. In this study, we described first the use of artificial trans-encoded sRNAs (atsRNAs) for specific gene silencing in bacteria. Based on the common structural characteristics of natural sRNAs in Gram-negative bacteria, we developed the designing principle of atsRNA. Most of the atsRNAs effectively suppressed the expression of exogenous EGFP gene and endogenous uidA gene in Escherichia coli. Further studies demonstrated that the mRNA base pairing region and AU rich Hfq binding site were crucial for the activity of atsRNA. The atsRNA-mediated gene silencing was Hfq dependent. The atsRNAs led to gene silencing and RNase E dependent degradation of target mRNA. We also designed a series of atsRNAs which targeted the toxic genes in Staphyloccocus aureus, but found no significant interfering effect. We established an effective method for specific gene silencing in Gram-negative bacteria. 相似文献
15.
16.
17.
Genomic imprinting is a developmentally regulated epigenetic phenomenon. The majority of imprinted genes only show parent-of-origin specific expression in a subset of tissues or at defined developmental stages. In some cases, imprinted expression is controlled by an imprinted macro non-coding RNA (ncRNA) whose expression pattern and repressive activity does not necessarily correlate with that of the genes whose imprinted expression it controls. This suggests that developmentally regulated factors other than the macro ncRNA are involved in establishing or maintaining imprinted expression. Here, we review how macro ncRNAs control imprinted expression during development and differentiation and consider how this impacts on target choice in epigenetic therapy. 相似文献
18.
19.
脑卒中严重影响着患者的生存质量,然而其病理生理机制尚不清晰.研究发现,长链非编码RNAs(long non-coding RNAs,lncRNAs)参与了机体多种生理或病理生理过程.在脑卒中患者或缺血性动物模型中,亦发现数百种异常表达的lncRNAs.因此,本综述主要讲述研究比较清晰并与脑卒中相关的lncRNAs的研究... 相似文献