共查询到20条相似文献,搜索用时 15 毫秒
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DNA binding and antigene activity of a daunomycin-conjugated triplex-forming oligonucleotide targeting the P2 promoter of the human c-myc gene 总被引:2,自引:2,他引:0
Carbone GM McGuffie E Napoli S Flanagan CE Dembech C Negri U Arcamone F Capobianco ML Catapano CV 《Nucleic acids research》2004,32(8):2396-2410
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Flexible DNA binding of the BTB/POZ-domain protein FBI-1 总被引:7,自引:0,他引:7
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Mikhail N Levit Bozena M Abramczyk Jeffry B Stock Edith H Postel 《The Journal of biological chemistry》2002,277(7):5163-5167
Nucleoside-diphosphate (NDP) kinase (NTP:nucleoside-diphosphate phosphotransferase) catalyzes the reversible transfer of gamma-phosphates from nucleoside triphosphates to nucleoside diphosphates through an invariant histidine residue. It has been reported that the high-energy phosphorylated enzyme intermediate exhibits a protein phosphotransferase activity toward the protein histidine kinases CheA and EnvZ, members of the two-component signal transduction systems in bacteria. Here we demonstrate that the apparent protein phosphotransferase activity of NDP kinase occurs only in the presence of ADP, which can mediate the phosphotransfer from the phospho-NDP kinase to the target enzymes in catalytic amounts (approximately 1 nm). These findings suggest that the protein kinase activity of NDP kinase is probably an artifact attributable to trace amounts of contaminating ADP. Additionally, we show that Escherichia coli NDP kinase, like its human homologue NM23-H2/PuF/NDP kinase B, can bind and cleave DNA. Previous in vivo functions of E. coli NDP kinase in the regulation of gene expression that have been attributed to a protein phosphotransferase activity can be explained in the context of NDP kinase-DNA interactions. The conservation of the DNA binding and DNA cleavage activities between human and bacterial NDP kinases argues strongly for the hypothesis that these activities play an essential role in NDP kinase function in vivo. 相似文献
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Identification of c-myc as a down-stream target for pituitary tumor-transforming gene 总被引:43,自引:0,他引:43
Pei L 《The Journal of biological chemistry》2001,276(11):8484-8491
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Function of the c-Myc oncoprotein. 总被引:17,自引:0,他引:17
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TGF-beta regulation of epithelial cell proliferation. 总被引:4,自引:0,他引:4
H L Moses 《Molecular reproduction and development》1992,32(2):179-184
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