共查询到20条相似文献，搜索用时 15 毫秒
1.
Mark J. Eisenberg 《Journal of chemical biology》2010,3(2):89-100
JOCB Bulletin
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JOCB BULLETIN
Welcome to the JOCB Bulletin 相似文献3.
Gernot Renger 《Journal of chemical biology》2010,3(3):141-156
JOCB Bulletin
Welcome to the JOCB Bulletin 相似文献4.
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JOCB BULLETIN
Welcome to the JOCB Bulletin 相似文献9.
JOCB Bulletin
Welcome to this edition of the JoCB Bulletin containing items of information for the Chemical Biology Community 相似文献10.
JOCB Bulletin
Welcome to this second edition of the JoCB Bulletin containing items of information for the Chemical Biology Community 相似文献11.
Mousumi Debnath Godavarthi B.K.S. Prasad Prakash S. Bisen 《Journal of chemical biology》2010,3(1):45-49
JOCB Bulletin
Welcome to this latest edition of the JoCB Bulletin containing items of information for the Chemical Biology Community 相似文献12.
《Journal of chemical biology》2009,2(3):153-160
JOCB Bulletin
Welcome to this latest edition of the JoCB Bulletin containing items of information for the Chemical Biology Community 相似文献13.
JOCB Bulletin
Welcome to this latest edition of the JoCB Bulletin containing items of information for the Chemical Biology Community 相似文献14.
Emmanuel Ampofo Sabrina WelkerMartin Jung Linda MüllerMarkus Greiner Richard ZimmermannMathias Montenarh 《Biochimica et Biophysica Acta (BBA)/General Subjects》2013
Background
Protein kinase CK2 is a pleiotropic enzyme which is ubiquitously expressed in eukaryotic cells. Several years ago CK2 was found to be associated with the mammalian endoplasmic reticulum. So far nothing is known about the function of CK2 at the ER.Methods
CK2 phosphorylation sites in the polypeptide chain of Sec63 were mapped using deletion mutants and a peptide library. Binding of Sec63 to CK2 and to Sec62 was analyzed by pull-down assays and by co-immunoprecipitationResults
Sec63 was identified as a novel substrate and binding partner of protein kinase CK2.We identified serine 574, serine 576 and serine 748 as CK2 phosphorylation sites. Phosphorylation of Sec63 by CK2 enhanced its binding to Sec62.Conclusions
Protein kinase CK2 phosphorylation of Sec63 leads to an enhanced binding of Sec63 to Sec62. This complex formation is a prerequisite for a functional ER protein translocon.General significance
Thus, our present data indicate a regulatory role of CK2 in the ER protein translocation. 相似文献15.
Objective
We aimed to estimate the Lanzhou lamb rotavirus (LLR) vaccination coverage (VC) and timeliness among children aged 2 to 59 months in Guangzhou, China.Methods
An electronic system-based VC survey was conducted using stratified cluster random sampling.Results
We reported an overall Lanzhou lamb rotavirus vaccine coverage of 25.3% among children aged 2-59 months (2-8 months, 2.6%) in Guangzhou, China.Conclusion
Great efforts should be taken to increase LLR VC in eligible children in Guangzhou, China. 相似文献16.
David Jos Coca Sandra Milena Castelblanco Diego Andrs Chavarro-Carvajal Luis Carlos Venegas-Sanabria 《Biomédica : revista del Instituto Nacional de Salud》2021,41(2):293
Introduction:
In-hospital complications frequently occur in hospitalized people over 65 worsening their clinical outcomes. There are, however, few studies on the factors associated with in-hospital complications in elderly patient care.Objective:
To evaluate factors associated with in-hospital complications in a geriatric acute care unit in Bogotá, ColombiaMaterials and methods:
We conducted an analytical, observational, retrospective study in a cohort of 1,657 patients over 65 years of age who received care in the geriatric unit of a high complexity hospital in Bogotá, Colombia. The dependent variable was in-hospital complications and the independent variables, the degree of functional dependence on admission, dementia, nutritional status, social support, comorbidity, and polypharmacy. We used Poisson’s linear regression model to identify associated variables.Results:
The bivariate analysis showed that functional dependence (PR=2.092, p≤0.001) and malnutrition (PR=2.850, p≤0.001) were associated with a higher rate of hospital-acquired infection. In the multivariate analysis, functional dependence (PR=1.931, p=0.003) and malnutrition (PR=2.502, p=0.002) remained independent factors for in-hospital complications.Conclusion:
In acute care centers, integral assessment at admission to identify functional dependence and malnutrition predicts in-hospital complications. 相似文献17.
18.
Chunhua Shi Matthew F. Paige Jason Maley Michèle C. Loewen 《Biochimica et Biophysica Acta (BBA)/General Subjects》2009
Background
The S. cerevisiae α-factor receptor, Ste2p, is a G-protein coupled receptor that plays key roles in yeast signaling and mating. Oligomerization of Ste2p has previously been shown to be important for intracellular trafficking, receptor processing and endocytosis. However the role of ligand in receptor oligomerization remains enigmatic.Methods
Using functional recombinant forms of purified Ste2p, atomic force microscopy, dynamic light scattering and chemical crosslinking are applied to investigate the role of ligand in Ste2p oligomerization.Results
Atomic force microscopy images indicate a molecular height for recombinant Ste2p in the presence of α-factor nearly double that of Ste2p alone. This observation is supported by complementary dynamic light scattering measurements which indicate a ligand-induced increase in the polydispersity of the Ste2p hydrodynamic radius. Finally, chemical cross-linking of HEK293 plasma membranes presenting recombinant Ste2p indicates α-factor induced stabilization of the dimeric form and higher order oligomeric forms of the receptor upon SDS-PAGE analysis.Conclusions
α-factor induces oligomerization of Ste2p in vitro and in membrane.General significance
These results provide additional evidence of a possible role for ligand in mediation of Ste2p oligomerization in vivo. 相似文献19.
William S. Harris Juhua Luo James V. Pottala Karen L. Margolis Mark A. Espeland Jennifer G. Robinson 《PloS one》2016,11(2)
Context
The relations between dietary and/or circulating levels of fatty acids and the development of type 2 diabetes is unclear. Protective associations with the marine omega-3 fatty acids and linoleic acid, and with a marker of fatty acid desaturase activity delta-5 desaturase (D5D ratio) have been reported, as have adverse relations with saturated fatty acids and D6D ratio.Objective
To determine the associations between red blood cell (RBC) fatty acid distributions and incident type 2 diabetes.Design
Prospective observational cohort study nested in the Women’s Health Initiative Memory Study.Setting
General population.Subjects
Postmenopausal women.Main Outcome Measures
Self-reported incident type 2 diabetes.Results
There were 703 new cases of type 2 diabetes over 11 years of follow up among 6379 postmenopausal women. In the fully adjusted models, baseline RBC D5D ratio was inversely associated with incident type 2 diabetes [Hazard Ratio (HR) 0.88, 95% confidence interval (CI) 0.81–0.95) per 1 SD increase. Similarly, baseline RBC D6D ratio and palmitic acid were directly associated with incident type 2 diabetes (HR 1.14, 95% CI 1.04–1.25; and HR 1.24, 95% CI 1.14–1.35, respectively). None of these relations were materially altered by excluding incident cases in the first two years of follow-up. There were no significant relations with eicosapentaenoic, docosahexaenoic or linoleic acids.Conclusions
Whether altered fatty acid desaturase activities or palmitic acid levels are causally related to the development of type 2 diabetes cannot be determined from this study, but our findings suggest that proportions of certain fatty acids in RBC membranes are associated with risk for type 2 diabetes. 相似文献20.
MicroRNA-190b confers radio-sensitivity through negative regulation of Bcl-2 in gastric cancer cells