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1.
Afef Bahlous Asma Krir Mehdi Mrad Mouna Bouksila Safa Kalai Osman Kilani Kateb Elhem Cheour El Hela Sahli Nizar Laadhari 《Journal of Medical Biochemistry》2022,41(2):168
BackgroundVitamin D deficiency is one of the most common medical conditions worldwide. In Tunisia, several studies evaluated Vitamin D status, but this was concerning specific populations (pregnant women, obese or diabetic patients and children with asthma). The only study that evaluated Vitamin D status in a healthy Tunisian population was conducted by Meddeb and associeties in 2002. The update of data available, based on the currently recommended limits, is necessary. This study aimed to estimate the prevalence of hypovitaminosis D in a healthy Tunisian population, and correlate the values with potential risk factors.MethodsIt was conducted on 209 Tunisian healthy subjects. Data collected included clinical characteristics and dietary intakes. We measured 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), glycemia, creatinine, calcium, phosphorus, and alkaline phosphatase concentrations. Hypovitaminosis D was retained for 25(OH)D concentrations <75 nmol/L. Vitamin D deficiency was defined by 25(OH)D concentrations <25 nmol/L.ResultsThe prevalence of hypovitaminosis D and vitamin D deficiency were respectively 92.3% and 47.6%. The main factors that were significantly associated with low vitamin D levels in our multivariate analysis were veiling, living in rural areas and sunscreen use. However, sex, age, socioeconomic level, phototype, solar exposure score, smoking and bone mass index, were not statistically associated with hypovitaminosis D. The study of relationship between vitamin D status and serum PTH levels showed a significative and negative correlation (P < 0.005).ConclusionsGiven the high prevalence of vitamin D, an adapted health policy is essential. A widespread vitamin D supplementation and food fortification seems to be necessary in Tunisia. 相似文献
2.
Lips P 《The Journal of steroid biochemistry and molecular biology》2004,(1-5):611-614
Moderate Vitamin D deficiency causes secondary hyperparathyroidism and bone loss, leading to osteoporosis and fractures. Controversy exists which circulating level of 25-hydroxyvitamin D (25OH)D is appropriate. The high incidence of hip fractures at northern latitudes suggest a relationship with Vitamin D deficiency. However, international studies show lower serum 25(OH)D levels in southern than in northern Europe. Serum 25(OH)D was not a risk factor for hip fractures in several epidemiological studies. The required serum 25(OH)D is usually established by assessing the point where serum parathyroid hormone (PTH) starts to rise. This point varied in several studies between 30 and 78 nmol/l. However, interlaboratory variation may also influence the apparent required serum 25(OH)D level. Dietary calcium intake influences serum PTH and serum PTH may influence the turnover of Vitamin D metabolites. A low calcium intake causes an increase of serum PTH and serum 1,25(OH)2D thereby decreasing the half life of serum 25(OH)D. While a low calcium intake may aggravate Vitamin D deficiency, a high calcium intake may have a Vitamin D sparing effect. With current knowledge, a global estimate for the appropriate serum 25(OH)D is 50 nmol/l. 相似文献
3.
The concern of this research was with the susceptibility of rodent reproduction to latitudinal acclimatization. More specifically, the relationship between ambient temperature and reproductive success was examined in house mice and deer mice whose ancestors had been trapped in northern versus southern climates (Alberta vs. Texas). Third generation adults of each of these four populations were paired and challenged to breed at -6 degrees, 3 degrees, 23 degrees or 34 degrees C. A 50-day period of gradual temperature adaptation preceded pairing. House mice, regardless of their geographic origin, were found to be relatively insensitive to extreme temperatures. Many pairs of both the Alberta and Texas stocks of this species still produced offspring when maintained at the experimental extremes of -6 degrees and 34 degrees C. In marked contrast, both northern and southern deer mice exhibited relatively narrow temperature ranges within which maximum breeding occurred: -6 degrees to 3 degrees for Texas deer mice and only at 23 degrees C for Alberta deer mice. Thus there is no evidence in either species that reproduction is either less sensitive to cold in northern latitudes or less sensitive to heat in southern latitudes; indeed, somewhat the reverse situation exists in deer mice. Evolutionarily, latitudinal considerations seem to have been of secondary rather than of primary importance in shaping the relationship between ambient temperature and reproduction in these two species. 相似文献
4.
Cold and heat tolerance of drosophilid flies with reference to their latitudinal distributions 总被引:1,自引:0,他引:1
Kimura MT 《Oecologia》2004,140(3):442-449
The relation between thermal tolerance and latitudinal distribution was studied with 30 drosophilid species collected from the cool-temperate region (Sapporo), the warm-temperate region (Tokyo and Kyoto) and the subtropical region (Iriomote island) in Japan. In addition, intraspecific variation was examined for five species collected from two localities. The subtropical strains of Scaptodrosophila coracina, Drosophila bizonata and D. daruma were less tolerant to cold than their temperate strains. However, the difference of cold tolerance between these two geographic strains was much smaller than the difference between the species restricted to the subtropical region and those occurring in the temperate region. In D. auraria and D. suzukii, no difference was observed in thermal tolerance between their cool- and warm-temperate strains. Thus, geographic variation in thermal tolerance within species was low or negligible. Interspecific comparisons by phylogenetic independent contrasts revealed that species which had the northern boundaries of their distributions at higher latitudes were generally more tolerant to cold than those which had their boundaries at lower latitudes. However, the data for some species did not agree with this trend. The use of man-protected warm places for overwintering, competition or predation would also affect their distributions. It also appeared that species which had their southern boundaries at higher latitudes were generally more cold-tolerant. The acquisition of cold tolerance may lower a flys capacity to compete, survive or reproduce in warmer climates. On the other hand, no relation was observed between heat tolerance and latitudinal distribution. Heat tolerance was higher in species inhabiting openlands or the forest canopy than in those inhabiting the forest understorey. 相似文献
5.
ALEXANDRE ROULIN RETO BURRI SYLVAIN ANTONIAZZA 《Biological journal of the Linnean Society. Linnean Society of London》2011,102(3):573-582
Climate change acts as a major new selective agent on many organisms, particularly at high latitudes where climate change is more pronounced than at lower latitudes. Studies are required to predict which species are at a high risk of extinction and whether certain phenotypes may be more affected by climate change than others. The identification of susceptible phenotypes is important for evaluating the potential negative effect of climate change on biodiversity at the inter‐ and intraspecific levels. Melanin‐based coloration is an interesting and easily accessible candidate trait because, within certain species, reddish pheomelanin‐based coloration is associated with adaptations to warm climates. However, it is unclear whether the same holds among species. We tested one prediction of this hypothesis in four owl genera (wood, scops, screech, and pygmy owls), namely that darker reddish species are more prevalent near the equator than polewards. Our comparative analysis is consistent with this prediction for the northern hemisphere, suggesting that pale reddish species may be adapted to cold climates and dark reddish species to warmer climates. Thus, climate change may have a larger negative impact on pale pheomelanic owls and favour dark pheomelanic species. © 2011 The Linnean Society of London, Biological Journal of the Linnean Society, 2011, 102 , 573–582. 相似文献
6.
Holick MF 《Progress in biophysics and molecular biology》2006,92(1):49-59
Vitamin D, the sunshine vitamin, has been recognized for almost 100 years as being essential for bone health. Vitamin D provides an adequate amount of calcium and phosphorus for the normal development and mineralization of a healthy skeleton. Vitamin D made in the skin or ingested in the diet, however, is biologically inactive and requires obligate hydroxylations first in the liver to 25-hydroxyvitamin D, and then in the kidney to 1,25-dihydroxyvitamin D. 25-Hydroxyvitamin D is the major circulating form of vitamin D that is the best indicator of vitamin D status. 1,25-dihydroxyvitamin D is the biologically active form of vitamin D. This lipid-soluble hormone interacts with its specific nuclear receptor in the intestine and bone to regulate calcium metabolism. It is now recognized that the vitamin D receptor is also present in most tissues and cells in the body. 1,25-dihydroxyvitamin D, by interacting with its receptor in non-calcemic tissues, is able to elicit a wide variety of biologic responses. 1,25-dihydroxyvitamin D regulates cellular growth and influences the modulation of the immune system. There is compelling epidemiologic observations that suggest that living at higher latitudes is associated with increased risk of many common deadly cancers. Both prospective and retrospective studies help support the concept that it is vitamin D deficiency that is the driving force for increased risk of common cancers in people living at higher latitudes. Most tissues and cells not only have a vitamin D receptor, but also have the ability to make 1,25-dihydroxyvitamin D. It has been suggested that increasing vitamin D intake or sun exposure increases circulating concentrations of 25-hydroxyvitamin D, which in turn, is metabolized to 1,25-dihydroxyvitamin D(3) in prostate, colon, breast, etc. The local cellular production of 1,25-dihydroxyvitamin D acts in an autocrine fashion to regulate cell growth and decrease the risk of the cells becoming malignant. Therefore, measurement of 25-hydroxyvitamin D is important not only to monitor vitamin D status for bone health, but also for cancer prevention. 相似文献
7.
Terenetskaya I 《The Journal of steroid biochemistry and molecular biology》2004,(1-5):623-626
Excessive UV exposures are commonly associated with adverse health effects, but proper amounts of UV are beneficial for people and essential in the natural production of Vitamin D(3) in skin. Two methods have been developed for direct evaluation of the Vitamin D synthetic capacity of sunlight (and artificial UV sources). The first one uses an in vitro model of Vitamin D(3) synthesis (ethanol solution of 7-dehydrocholesterol, 7-DHC), and concentration of previtamin D(3) accumulated during an UV exposure is determined using specially designed spectrophotometric analysis. The second method utilizes photoisomerization of provitamin D in nematic liquid crystalline (LC) matrix, and visual estimation of accumulated previtamin D becomes possible due to special design of a LC cell. This user-friendly method is appropriate for personal UV dosimetry and may have wide application in tanning saloons, in clinical dermatology and UV therapy. 相似文献
8.
Until recently it had been widely accepted that birds are energetically adapted to the latitude they inhabit, having an increased basal metabolic rate (BMR) at higher latitudes. Latterly, this general view has been questioned and the influence of phenotypic flexibility, due to factors such as habitat, life‐history or acclimatization has received increased attention. In particular, focus has been directed towards comparing species from arid and mesic habitats, but less attention has been given to species which breed in cold climates. We chose to study northern wheatears Oenanthe oenanthe from two populations at different latitudes (southern Norway, Iceland), but with similar life‐histories and habitat requirements throughout the year, in a common‐garden experiment. In order to assess true latitudinal trends in metabolic rate, we estimated the nocturnal resting metabolic rate (RMR) of northern wheatears from southern Norway and Iceland at different temperatures from 0° to 30°C. We found that Norwegian birds had overall lower metabolic rates than Icelandic birds, which were also slightly larger. This difference was not observed at 0°C, which might indicate that Icelandic birds might rely on better feather insulation reducing metabolic costs at very low temperatures. At temperatures above 10°C birds of both populations had constant metabolic values, indicating that their thermoneutral range almost completely covered the temperatures experienced during the breeding period. This study shows that the northern wheatear, which is one of only a few insectivorous long‐distance migratory songbirds occurring at such high latitudes, has evolved metabolic adaptations to life at cold temperatures which are endogenously determined. 相似文献
9.
Sayre RM Dowdy JC Shepherd JG 《The Journal of steroid biochemistry and molecular biology》2007,103(3-5):686-688
As early as 1930 sunlamps claiming to provide ultraviolet (UV) exposure to make vitamin D were sold to the public in the US and Canada for home use. Today even with dietary supplementation of vitamin D many people do not get enough solar UV exposure to maintain sufficient vitamin D levels. There is growing interest in the availability of sunlamps for this purpose. The original Sperti Sunlamp, with label claiming vitamin D benefit was approved by the American Medical Association in 1940 as a sunlamp. This intermediate pressure mercury lamps ultraviolet B emission lines, at 297, 302, and 313 nm are able to convert 7-dehydrocholesterol in the skin to vitamin pre-D3 initiating the natural process of vitamin D formation. Today's KBD Vitamin D lamp, an updated model of the earlier type source. In order to comply with modern safety guidance, the source is filtered to remove unnecessary UVC radiation and is equipped with a timer to control the dose administered. The 5 min timer provides an exposure, at 20 in. from the user's skin, of one standard erythemal dose (SED). The SED represents a suberythemal dose for even the most sensitive skin type I individual. 相似文献
10.
The impact of growing-season length variability on carbon assimilation and evapotranspiration over 88 years in the eastern US deciduous forest 总被引:17,自引:0,他引:17
Recent research suggests that increases in growing-season length (GSL) in mid-northern latitudes may be partially responsible
for increased forest growth and carbon sequestration. We used the BIOME-BGC ecosystem model to investigate the impacts of
including a dynamically regulated GSL on simulated carbon and water balance over a historical 88-year record (1900–1987) for
12 sites in the eastern USA deciduous broadleaf forest. For individual sites, the predicted GSL regularly varied by more than
15 days. When grouped into three climatic zones, GSL variability was still large and rapid. There is a recent trend in colder,
northern sites toward a longer GSL, but not in moderate and warm climates. The results show that, for all sites, prediction
of a long GSL versus using the mean GSL increased net ecosystem production (NEP), gross primary production (GPP), and evapotranspiration
(ET); conversely a short GSL is predicted to decrease these parameters. On an absolute basis, differences in GPP between the
dynamic and mean GSL simulations were larger than the differences in NEP. As a percentage difference, though, NEP was much
more sensitive to changes in GSL than were either GPP or ET. On average, a 1-day change in GSL changed NEP by 1.6%, GPP by
0.5%, and ET by 0.2%. Predictions of NEP and GPP in cold climates were more sensitive to changes in GSL than were predictions
in warm climates. ET was not similarly sensitive. First, our results strongly agree with field measurements showing a high
correlation between NEP and dates of spring growth, and second they suggest that persistent increases in GSL may lead to long-term
increases in carbon storage.
Received: 26 May 1998 / Accepted: 6 July 1998 相似文献
11.
White CR Alton LA Frappell PB 《Proceedings. Biological sciences / The Royal Society》2012,279(1734):1740-1747
Metabolic cold adaptation (MCA), the hypothesis that species from cold climates have relatively higher metabolic rates than those from warm climates, was first proposed nearly 100 years ago and remains one of the most controversial hypotheses in physiological ecology. In the present study, we test the MCA hypothesis in fishes at the level of whole animal, mitochondria and enzyme. In support of the MCA hypothesis, we find that when normalized to a common temperature, species with ranges that extend to high latitude (cooler climates) have high aerobic enzyme (citrate synthase) activity, high rates of mitochondrial respiration and high standard metabolic rates. Metabolic compensation for the global temperature gradient is not complete however, so when measured at their habitat temperature species from high latitude have lower absolute rates of metabolism than species from low latitudes. Evolutionary adaptation and thermal plasticity are therefore insufficient to completely overcome the acute thermodynamic effects of temperature, at least in fishes. 相似文献
12.
Michael G Kimlin Kathryn A Schallhorn 《Photochemical & photobiological sciences》2004,3(11-12):1067-1070
Human exposure to sunlight promotes the formation of pre-vitamin D in the skin. Low or marginal levels of vitamin D has been linked to a wide range of human health outcomes, including the development of various types of cancer. However, few data exist on the actual exposure to human due to vitamin D producing ultraviolet radiation. Most studies of human disease and vitamin D have linked latitude and location of residence to expected exposure form the available ambient UV radiation. Human UV exposure for the development of vitamin D depends on a variety of factors such as time spent outdoors, percent available skin, skin type, UV protective devices used and distribution of UV over the human form. In this paper, we investigate how latitude impacts not only on the amount of UV available for vitamin D synthesis, but also the distribution of UV over the human form. 相似文献
13.
We review the general amount and patterns of exposure to solar ultraviolet (UV) radiation that children and teenagers experience and the spectrum of UV-related skin damage that can occur as a result. Data about the amount of solar UV received by children and teenagers are relatively few but suggest that around 40–50% of total UV to age 60 occurs before age 20. Among white children, those with the palest complexions suffer the most damage. Comparisons of prevalence and incidence of outcomes in children and teenagers sharing common ancestry, but living at different latitudes, show that prevalence rates of photoaging and melanocytic naevi are higher in Australian compared with British children, and similarly for melanoma. Genetic risk for the majority of the melanomas in teens is a function of genes controlling naevus propensity and pigmentation in the skin. High numbers of naevi and freckles, red hair, blue eyes, inability to tan, as well as a family history are the primary determinants of melanoma among adolescents. Beyond the signs of skin damage seen in children are the latent effects observed later in adulthood. Childhood is believed to be a susceptible window for long-term harmful effects of UV, as evidenced by clear differences in skin cancer risk between child and adult migrants from high to low latitudes. Effective UV radiation protection from childhood is necessary to control both immediate and long-term harmful effects on children’s skin. 相似文献
14.
Eyles D Almeras L Benech P Patatian A Mackay-Sim A McGrath J Féron F 《The Journal of steroid biochemistry and molecular biology》2007,103(3-5):538-545
Epidemiology has highlighted the links between season of birth, latitude and the prevalence of brain disorders such as multiple sclerosis and schizophrenia. In line with these data, we have hypothesized that ‘imprinting’ with low prenatal vitamin D could contribute to the risk of these two brain disorders. Previously, we have shown that transient developmental hypovitaminosis D induces permanent changes in adult nervous system. The aim of this study was to examine the impact of prenatal hypovitaminosis D on gene expression in the adult rat brain. Vitamin D deficient female rats were mated with undeprived males and the offspring were fed with a control diet after birth. At Week 10, gene expression in the progeny's brain was compared with control animals using Affymetrix gene microarrays. Prenatal hypovitaminosis D causes a dramatic dysregulation of several biological pathways including oxidative phosphorylation, redox balance, cytoskeleton maintenance, calcium homeostasis, chaperoning, post-translational modifications, synaptic plasticity and neurotransmission. A computational analysis of these data suggests that impaired synaptic network may be a consequence of mitochondrial dysfunction. Since disruptions of mitochondrial metabolism have been associated with both multiple sclerosis and schizophrenia, developmental vitamin D deficiency may be a heuristic animal model for the study of these two brain diseases. 相似文献
15.
Within North America, northern (Glaucomys sabrinus) and southern (Glaucomys volans) flying squirrels occupy distinct ranges with limited overlap. Sympatry in northern latitudes coincides with northern hardwood vegetation from Minnesota to New England. Strongyloides robustus is an intestinal parasite that infects both species but appears to be deleterious only to northern flying squirrels. As a result, S. robustus could be a critical determinant of flying squirrel population characteristics in at least some areas of sympatry. However, cold weather could potentially limit the distribution of S. robustus in northern climates. Therefore, we assessed fecal samples from both flying squirrel species to determine the presence of the nematode in Wisconsin. Strongyloides robustus was found in 12 flying squirrel scat samples and infected 52% of southern flying squirrels and 11% of northern flying squirrels. Prevalence of S. robustus infection for northern flying squirrels was substantially lower than previously reported from more southern regions. This is the northernmost documentation of S. robustus in flying squirrels and the first documentation of S. robustus parasitizing flying squirrels in Wisconsin. 相似文献
16.
Effects on seed germination of temperatures ranging from −2 C to +29 C were tested inDioscorea nipponica, D. tokoro, D. japonica, D. tenuipes, D. septemloba andD. quinqueloba which orginate in the temperate zone; they are distributed from northern cold areas to southern warm areas approximately
in this order in Japan. After water imbibition of these seeds, chilling induced full germination, and high temperatures over
23 C induced a secondary dormancy, but sensitivities to the chilling and to the high temperatures differed with species. Cold-climate
species germinated rapidly at higher temperatures after a short-term chilling or even without chilling, whereas warm-climate
species required chilling of a rather long period for germination; thus, among 6 species tested, favourable temperatures for
germination and climatic temperatures of distribution area were conversely correlated.
Seeds ofD. tokoro andD. japonica collected from several populations grown in different climates were also tested for germination at 11 to 29 C; seeds from
warm climates germinated rather slowly compared to seeds from cold climates.
These inte- and intra-specific adaptation manners in the temperature members of the genusDioscorea are entirely different from those of many other plant genera reported by some workers. 相似文献
17.
If heat generated through activity can substitute for heat required for thermoregulation, then activity in cold environments may be energetically free for endotherms. Although the possibility of activity-thermoregulatory heat substitution has been long recognized, its empirical generality and ecological implications remain unclear. We combine a review of the literature and a model of heat exchange to explore the generality of activity-thermoregulatory heat substitution, to assess the extent to which substitution is likely to vary with body size and ambient temperature, and to examine some potential macroecological implications. A majority of the 51 studies we located showed evidence of activity-thermoregulatory heat substitution (35 of 51 studies), with 28 of 32 species examined characterized by substitution in one or more study. Among studies that did detect substitution, the average magnitude of substitution was 57%, but its occurrence and extent varied taxonomically, allometrically, and with ambient temperature. Modeling of heat production and dissipation suggests that large birds and mammals, engaged in intense activity and exposed to relatively warm conditions, have more scope for substitution than do smaller endotherms engaged in less intense activity and experiencing cooler conditions. However, ambient temperature has to be less than the lower critical temperature (the lower bound of the thermal neutral zone) for activity-thermoregulatory heat substitution to occur and this threshold is lower in large endotherms than in small endotherms. Thus, in nature, substitution is most likely to be observed in intermediate-sized birds and mammals experiencing intermediate ambient temperatures. Activity-thermoregulatory heat substitution may be an important determinant of the activity patterns and metabolic ecology of endotherms. For example, a pattern of widely varying field metabolic rates (FMR) at low latitudes that converges to higher and less variable FMR at high latitudes has been interpreted as suggesting that warm environments at low latitudes allow a greater variety of feasible metabolic niches than do cool, high-latitude environments. However, activity-thermoregulatory heat substitution will generate this pattern of latitudinal FMR variation even if endotherms from cold and warm climates are metabolically and behaviorally identical, because the metabolic rates of resting and active animals are more similar in cold than in warm environments. Activity-thermoregulatory heat substitution is an understudied aspect of endotherm thermal biology that is apt to be a major influence on the physiological, behavioral and ecological responses of free-ranging endotherms to variation in temperature. 相似文献
18.
Environmental conditions may provide specific demands for memory, which in turn may affect specific brain regions responsible for memory function. For food-caching animals, in particular, spatial memory appears to be important because it may have a direct effect on fitness via the accuracy of cache retrieval. Animals living in more harsh environments should rely more on cached food, and thus theoretically should have better memory to support cache retrieval, which may be crucial for survival. Consequently, animals in harsh environments may benefit from more neurons within a larger hippocampus (Hp), a part of the brain involved in spatial memory. Here, we present the first large-scale test of the hypothesis that Hp structure is related to the severity of the environment within a single food-caching species (the black-capped chickadee, Poecile atricapillus) with a large range encompassing a great diversity of climatic conditions. Hp size in birds collected at five locations along a gradient of environmental harshness from Alaska to Kansas ranked perfectly with climatic severity. Birds from more harsh northern climates (defined by lower ambient temperature, shorter day length and more snow cover) had significantly larger Hp volumes and more Hp neurons (both relative to telencephalon volume) than those from more mild southern latitudes. Environmental pressures therefore seem capable of influencing specific brain regions independently, which may result in enhanced memory, and hence survival, in harsh climates. 相似文献
19.
Assessing migration patterns of sharp-shinned hawks Accipiter striatus using stable-isotope and band encounter analysis 总被引:1,自引:0,他引:1
Intraspecific migration patterns in birds have both spatial and temporal components. Two commonly reported spatial patterns are leap-frog and chain migration. Temporal migration patterns refer to the timing of migration of populations from different breeding latitudes. We investigated the spatial and temporal migration patterns of hatching-year (HY) sharp-shinned hawks Accipiter striatus of interior North America using stable-hydrogen isotope and band encounter analyses. Feather samples were collected from hawks migrating through New Mexico, USA and measured for their stable-hydrogen isotope ratios (δD) to distinguish individuals originating from relatively high and low natal latitudes. We then examined the relationship between feather δD values and passage dates through New Mexico, USA. We also gathered band encounter data from the Bird Banding Lab of the United States Geological Survey to determine the wintering latitudes of HY sharp-shinned hawks relative to their passage date through migration banding sites in interior North America. Combining these data, we found that during fall migration HY sharp-shinned hawks used a chain migration pattern, that is, hawks originating from lower latitudes wintered further south than those from higher latitudes. In addition, birds originating from lower latitudes passed through interior North America earlier than those from higher latitudes. We also found that hawks from higher latitudes were significantly larger than those from lower latitudes, and that females from higher latitudes had significantly higher estimated fat levels than females from lower latitudes. 相似文献
20.
Melanin provides a crucial filter for solar UV radiation and its genetically determined variation influences both skin pigmentation and risk of cancer. Genetic evidence suggests that the acquisition of a highly stable melanocortin 1 receptor allele promoting black pigmentation arose around the time of savannah colonization by hominins at some 1–2 Ma. The adaptive significance of dark skin is generally believed to be protection from UV damage but the pathologies that might have had a deleterious impact on survival and/or reproductive fitness, though much debated, are uncertain. Here, I suggest that data on age-associated cancer incidence and lethality in albinos living at low latitudes in both Africa and Central America support the contention that skin cancer could have provided a potent selective force for the emergence of black skin in early hominins. 相似文献