Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism

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Kinetochore stretching-mediated rapid silencing of the spindle-assembly checkpoint required for failsafe chromosome segregation

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Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes

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Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex

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A unique macrophage subpopulation signals directly to progenitor cells to promote regenerative neurogenesis in the zebrafish spinal cord

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Nesprin-2 Recruitment of BicD2 to the Nuclear Envelope Controls Dynein/Kinesin-Mediated Neuronal Migration In Vivo

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Rewiring Neuronal Glycerolipid Metabolism Determines the Extent of Axon Regeneration

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PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway

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Impact of WIN site inhibitor on the WDR5 interactome

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Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1

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HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway

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Regulation of Multiple Fission and Cell-Cycle-Dependent Gene Expression by CDKA1 and the Rb-E2F Pathway in Chlamydomonas

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Definition of a small core transcriptional circuit regulated by AML1-ETO

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Molecular insight into the PCNA-binding mode of FBH1

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Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A

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Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis

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RIF1 suppresses the formation of single-stranded ultrafine anaphase bridges via protein phosphatase 1

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An acentriolar centrosome at the C. elegans ciliary base

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Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors

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On the role of p53 in the cellular response to aneuploidy

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