Depletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces

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Structure and regulation of the myotonic dystrophy kinase-related Cdc42-binding kinase

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A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling

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Glial-secreted Netrins regulate Robo1/Rac1-Cdc42 signaling threshold levels during Drosophila asymmetric neural stem/progenitor cell division

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A comprehensive phenotypic CRISPR-Cas9 screen of the ubiquitin pathway uncovers roles of ubiquitin ligases in mitosis

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Mechanism of Lys6 poly-ubiquitin specificity by the L. pneumophila deubiquitinase LotA

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Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication

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Mitotic kinase oscillation governs the latching of cell cycle switches

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Ribosomal DNA replication time coordinates completion of genome replication and anaphase in yeast

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E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response

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The Ufd1 cofactor determines the linkage specificity of polyubiquitin chain engagement by the AAA+ ATPase Cdc48

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Differential condensation of sister chromatids acts with Cdc6 to ensure asynchronous S-phase entry in Drosophila male germline stem cell lineage

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Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

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A lncRNA fine-tunes salicylic acid biosynthesis to balance plant immunity and growth

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Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks

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Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring

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CpG island reconfiguration for the establishment and synchronization of polycomb functions upon exit from naive pluripotency

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HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases

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Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling

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Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study

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