Structure of the human UBR5 E3 ubiquitin ligase

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Multiple ubiquitin E3 ligase genes antagonistically regulate chloroplast-associated protein degradation

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E6AP AZUL interaction with UBQLN1/2 in cells,condensates, and an AlphaFold-NMR integrated structure

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Systemwide disassembly and assembly of SCF ubiquitin ligase complexes

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A comprehensive phenotypic CRISPR-Cas9 screen of the ubiquitin pathway uncovers roles of ubiquitin ligases in mitosis

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TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity

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Aberrant RNA methylation triggers recruitment of an alkylation repair complex

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Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition

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A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing

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In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target

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GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme

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Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters

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Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins

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FBXW7 Confers Radiation Survival by Targeting p53 for Degradation

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Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly

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Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions

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Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases

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The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins

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Sensing of individual stalled 80S ribosomes by Fap1 for nonfunctional rRNA turnover

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An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes

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