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<正>Hepatitis B virus(HBV)infection remains a major global health problem because current therapies rarely eliminate the replicative template of HBV,which is the covalently closed circular DNA(ccc DNA).As an accurate and efficient genome editing tool,clustered regularly interspaced palindromic repeat(CRISPR)-associated(Cas)9 system represents a very promising potential     

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Impacts of climate change on algae, like within this seaweed‐dominated shoreline in Brixham, UK, are compounded by direct and indirect interactions between the algae, their associated communities, and the environment. Photo by Rebecca Kordas. [Vol. 48, No. 5, pp. 1064‐1078]     

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<正>Coxsackievirus B3(CVB3) is a pathogenic enterovirus of Picornaviridae family. Lnc RNAs are an important subgroup of non-coding RNAs and actively transcribed in large numbers in human genome. They are widely involved in various physiological and pathological processes, including viral infection. In this issue, Tong et al. profiled     

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<正>Human cytomegalovirus(HCMV)infection is a leading cause of birth defects,primarily affecting the central nervous system and causing its maldevelopment.Hes1,a downstream effector of Notch signaling pathway,plays an essential role on maintaining neural progenitor/stem cells(NPCs)cell fate and fetal brain development.In this issue,Xi-Juan Liu et al.reported the first observation     

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正Flaviviruses, including the dengue, Zika, West Nile, tick-borne encephalitis and yellow fever viruses (DENV, ZIKV, WNV, TBEV and YFV, respectively), are a genus of mostly arthropod-borne RNA viruses that cause a range of pathologies in humans. The success of productive infection of human cells by flaviviruses depends in part on the     

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<正>Phage display is a method for the study of protein-or peptide-biological molecule interactions that utilize bacteriophages to connect peptides with the genetic information that encodes them.The filamentous bacteriophage M13,which can be functionalized by genetic engineering and chemical conjugation     

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<正>The outcome of hepatic B virus(HBV)infection is the result of complex interactions between replicating HBV and the innate/adaptive immune system.As an important lectin complement pathway activator,human ficolin-2 is secreted from liver cells and contributes to the clearance of viral infections and lysis of enveloped virions,which has been implicated as an anti-infection innate immune molecule.In this issue,a research group lead by Drs.XiaoLian Zhang and Fengling Luo,investigated the serum and liver tissue ficolin-2     

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Ultrastructural analysis reveals how the calcifying haptophyte Scyphosphaera apsteinii engineers and secretes its polymorphic calcite coccoliths to construct the external coccosphere. [Vol. 48, No. 6, pp. 1343–1361]     

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正While host proteins incorporated into virions during viral budding from infected cell are known to play essential roles in multiple process of viral life cycle of progeny virus, these characteristics have been largely neglected in studies on rabies virus (RABV). In this issue, Zhang et al. performed proteomics studies     

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正Over the past few years,a rising trend of emerging andv irulent infectious diseases has been observed.Among the emerging viral infections,more than 75%are natural focal diseases.Natural focal viruses generally recycle in wild animals with relatively large populations as natural hosts,such as bats,rodents,and birds,and are transmitted by vectors such as ticks and mosquitoes that co-exist in the specifi c natural foci.A program     

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正Viral pathogens frequently hijack the host actin polymerization machinery to facilitate their infection.Autographa californica multicapsid nucleopolyhedrovirus(AcM NPV)is one of the unique insect virus that inducing actin polymerization occurring in the nucleus,which requires relocation of cytoplasmic actin polymerization machinery,including actin-related protein 2/3 complex(Arp2/3),to the nucleus.Therefore,the alphabaculovirus-infection system could serve as a     

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<正>This issue of Virologica Sinica is to celebrate the 100th anniversary of the discovery of filterable lytic factor or bacteriophage(1915-2015).During the past 100 years,both basic knowledge and applications of bacteriophages have been substantially explored and developed.In recent years,bacteriophage research is booming and holding the hope     

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正Stress granules(SGs)are intracellular granules formed when cellular translation is blocked.Viral infections can induce the formation of SGs,which in turn promote or inhibit viral infection.In this issue,Xia Zhai et al.investigated the effect of coxsackievirus B type 3(CVB3)infection on SG formation,and found that CVB3 could induce SG formation in the early phase     

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正Recent large outbreaks of Zika vrius (ZIKV)in Oceania's islands and the Americas have linked the ZIKV infection with occurrence of microcephaly in newborns.The virus can be passed from a pregnant woman to her fetus.Even worse,ZIKV has now spread to nearly 30 areas worldwide and become     

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<正>Immunofluorescence microscopy of a chimeric mouse liver repopulated with human hepatocytes.Productive infection of human hepatocytes within a chimeric mouse by hepatitis C virus(HCV)reveals antagonism of the RIGI-like receptor pathway.Due to cleavage of the central adaptor protein MAVS,HCV(green)infected hepatocytes do not exhibit nuclear translocation of the     

ON THE COVER

正Cover Caption:Subcellular localization of Os ZFP Auxin plays a crucial role in lateral root development.In this issue,Cui et al.(pp.496–505)report in rice that OsZ FP as a C2HCtype zinc fi nger protein participates in IAA signal pathways to control lateral root development by interacting with cyclophilin.