Pressure and life: some biological strategies

All biological processes of life on Earth experience varying degrees of pressure. Aquatic organisms living in the deep-sea, as well as chondrocytic cells of articular cartilage are exposed to hydrostatic pressures that rise up to several hundred times that of atmospheric pressure. In the case of marine larvae that disperse through the oceanic water column, pressure changes might be responsible for stress conditions during development, limiting colonisation capabilities. In a number of biological systems, life strategies may be significantly influenced by pressure. In this review, we will focus on the consequences of pressure changes on various biological processes, and more specifically on animals living in the deep-sea. Revisiting general principles of pressure effects on biological systems, we present recent data illustrating the diversity of effects pressure may have at different levels in biological systems, with particular attention to effects on gene expression. After a review of the main pressure equipments available today for studying species living naturally at high pressure, we summarise what is known concerning pressure impact during animal development.     

John Tileston Edsall: some selected biography and personal reminiscences

This paper has been written in honor of John T. Edsall. Its purpose is to review briefly the status of science during his active years and the combination of personal qualities and upbringing which resulted in his enormous impact on the field of biochemistry. There was an unusual combination of deep knowledge and interest in many intellectual areas by no means restricted to science; the large number of individuals he met by intent or by chance, many to become fast friends for life, who themselves became distinguished in science; and last but not least his influence on science policy through very clear statements and his moral positions on questions of the day.