共查询到20条相似文献,搜索用时 15 毫秒
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Elaine B. Vickers 《Inorganica chimica acta》2004,357(13):3889-3894
Magnetically ordered Ni[TCNE]2 · zCH2Cl2 (Tc = 13 K) is reported for the first time from the reaction of Ni(CO)4 with tetracyanoethylene (TCNE). A family of new solid solution room temperature magnets of VxNi1 − x[TCNE]y · zCH2Cl2 (0 ? x < 1; y ? 2) composition has been characterized by IR spectrometry, elemental analysis, and magnetic measurements (ac and dc susceptibility). Substitution of NiII for VII in V[TCNE]y · zCH2Cl2 does not alter the Tc significantly for x ? 0.05 and does not alter Hcr significantly for x > 0; however, the magnitude of M increases with x, as does the broadness of the peaks in the χ′(T) and χ″(T) ac susceptibilities. Hence, the magnetic properties of the room temperature V[TCNE]y · zCH2Cl2 magnet can be finely tuned via synthetic chemistry methodology, making this material more amenable in future technologies. 相似文献
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Michael C. Koss 《Prostaglandins & other lipid mediators》1976,12(6):997-1004
Prostaglandin F2α (5μg/kg, i.v.) causes an increase in pulmonary arterial pressure, decrease in systemic arterial pressure, and reflex bradycardia in the anesthetized cat. The same dose of the 15-methyl analogue of PGF2α produces the same triad of effects but of greater magnitude and duration. Although prostaglandins F1α, F2β and F1β also cause the same cardiovascular effects as F2α, there is a decrease in potency for all parameters measured, with PGF2α>PGF1α>PGF2β>PGF1β. When compared to the actions of PGF2α in producing an increase in pulmonary arterial pressure, PGs F1α, F2β and F1β were less potent by approximately 10, 100, and 1000 fold respectively. 相似文献
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《Ethology : formerly Zeitschrift fur Tierpsychologie》1983,61(4):351-360
Book reviewed in this article: Bücher/Books: Stamm, R. A., und H. Zeier, eds. (1978): LORENZ und die Folgen: Tierpsychologie. Chivers, D. J., and E. H. R. Ford, eds. (1978): Recent advances in primatology, Vol. Fölsch, D. W., und A. Nabholz (1982): Ethologische Aussagen zur artgerechten Nutztierhaltung (Ethological aspects in breeding of farm animals). Blösch, M., ed. (1981): Die Beeinflussung angeborener Verhaltensweisen durch neurotrope Substanzen (Influences of neurotropic substances on innate behaviour patterns). Neumann, G.-H. (1981): Normatives Verhalten und aggressive Außenseiterreaktionen bei gesellig lebenden Vögeln und Säugern (Normative behaviour and aggression against oddity in social birds and mammals). Brain, P. F., and D. Benton (1981): Multidisciplinary approaches to aggression research (Aggressionsforschung verschiedener Fachrichtungen). Omark, D. R., F. F. Strayer and G. Freedman, eds. (1980): Dominance relations: an ethological view of human conflict and social interaction (Rangordnung: eine ethologische Betrachtung sozialer Beziehungen und Konflikte des Menschen). Bresson, F., P.-H. Chombart de Lauwe, M. Cullen, G. Th. Guilbaud, J. Paillard, E. de Renzi, and E. Vurpillot (1974): De l'espace corporel à l'espace écologique (From body space to ecological space). Association de Psychologie scientifique de Langue française nimmt interessierte Wissenschaftler auch anderer Fachrichtungen auf, Jahresbeitrag 25 FF. Psychologischer Index—Referatedienst über die psychologische Literatur aus den deutschsprachigen Ländern. 相似文献
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Denervation and other forms of stimulus deprivation cause an increase in the magnitude of subsequent responses, a phenomenon commonly referred to as denervation supersensitivity. This has been well demonstrated with the cyclic AMP response to norepinephrine in the pineal gland. In the present report, we address the question of whether stimulus deprivation alters alpha and beta subunits of the GTP binding regulatory protein that stimulates adenylyl cyclase activity (Gs). Stimulus deprivation of the pineal gland was produced by denervation (superior cervical ganglionectomy), decentralization of the superior cervical ganglia, or by exposure of the animal to continuous lighting. All increased both the alpha and beta subunits of Gs (Gs alpha and G beta) by up to fourfold, as estimated using semiquantitative western blot technology. These effects were detectable after 1 day of stimulus deprivation and were sustained for 2 weeks. The stimulatory effects of constant light-induced stimulus deprivation were also apparent by measuring cholera toxin-dependent ADP-ribosylation of Gs alpha, which revealed a four-fold increase in the amount of labeled substrate. The results of in vivo studies were confirmed with in vitro studies, which demonstrated a spontaneous increase in both Gs alpha and G beta during 72 h of organ culture. The constant light-induced increases in both Gs alpha and G beta were prevented by continuous administration of isoproterenol (0.3 mg/kg/day), supporting the suggestion that adrenergic stimulation controls the levels of Gs alpha and G beta. These studies indicate that stimulus deprivation increases both Gs alpha and G beta.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
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General anesthetics modulate the activity of ligand-gated ion channels including the GABA(A) receptor. Mutational studies mainly on the benzodiazepine-insensitive alpha(2)beta(1(M286W)) and alpha(6)beta(3(N289M))gamma(2) GABA(A) receptors revealed that a serine in transmembrane domain 2 and a methionine in transmembrane domain 3 are essential for the action of most general anesthetics. We investigated whether these residues would similarly be relevant for their action at the benzodiazepine-sensitive GABA receptor subtype, alpha(2)beta(3)gamma(2). We found that not only the N265M but also the M286W mutation nearly abolished the modulatory effect of etomidate. However, the anti-convulsant loreclezole, a structural homologue of etomidate, was inactive on the N265M mutant, but displayed normal modulatory activity on the M286W mutant. Both mutations did not affect the modulatory action of the neurosteroid alphaxalone. The direct action of alphaxalone, however, was dramatically increased in the M286W mutant to about twice the maximal GABA current but not significantly affected in the N265M mutant. These data demonstrate that the structural requirements for modulatory and direct actions of various general anesthetics are distinct. The molecular switches induced by these mutations can be exploited to identify the molecular determinants for the action of general anesthetics. 相似文献
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Hongyan Long Jie Ruan Mengjiao Zhang Chunyan Wang Yaruo Huang 《Journal of biochemical and molecular toxicology》2019,33(10)
The aim is to study the effects of gastrodin (GA) on striatal inflammation and oxidative stress in rats with Tourette syndrome (TS). The rat model of TS was induced by 3,3′‐iminodipropionitrile. Behavioral tests were carried out by stereotype experiment. The concentrations of amino acid transmitters glutamic acid (Glu) and γ‐aminobutyric acid (GABA) in striatum were determined by high‐performance liquid chromatography. Superoxide dismutase (SOD) and malondialdehyde (MDA) in serum and striatum were detected by commercial kits. Cytokines in serum and striatum were detected by enzyme‐linked immunosorbent assay kits. Western blot analysis was used to detect striatum nuclear erythroid factor 2‐related factor 2 (Nrf‐2)/heme oxygenase‐1 (HO‐1)/high mobility group box 1 protein (HMGB1)/nuclear factor‐кB (NF‐кB) pathway‐related proteins. The expressions of Nrf‐2 and P‐NF‐кBp65 in striatum were detected by immunohistochemistry. Compared with the control group, the stereotype scores of rats in the model group significantly increased, and the contents of Glu and GABA in striatum obviously increased. GA significantly reduced the stereotype scores and decreased the contents of Glu and GABA. The levels of SOD in serum and striatum were decreased and the content of MDA in serum and striatum were increased compared with the control group, while GA significantly restored the changes. GA significantly adjusted Nrf‐2/HO‐1/HMGB1/NF‐кB pathway‐related proteins changes consistent with immunohistochemical changes. GA may protect striatum of rats with TS by regulating Nrf‐2/HO‐1/HMGB1/NF‐кB pathway protein changes in striatum. 相似文献
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Low-temperature, single crystal X-ray structural characterisations of trans-[NiCl2(HOMe)4], trans-O-[Ni(MeOH)2(μ-Cl)(2/2)2](∞∣∞) · 0.5dioxan and trans-trans-[Ni(H2O)2Cl2(O-dioxan-O)(2/2)](∞∣∞) · dioxan are recorded, offering intriguing insights into O-donor/Ni(II) relativities. All nickel atoms in all structures are located on crystallographic inversion centres, the last two compounds being one-dimensional polymers. 相似文献
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The kinetics of single-electron injection into the oxidized nonrelaxed state (OH → EH transition) of the aberrant ba3 cytochrome oxidase from Thermus thermophilus, noted for its lowered efficiency of proton pumping, was investigated by time-resolved optical spectroscopy. Two main phases of intraprotein electron transfer were resolved. The first component (τ ∼ 17 μs) reflects oxidation of CuA and reduction of the heme groups (low-spin heme b and high-spin heme a3 in a ratio close to 50:50). The subsequent component (τ ∼ 420 μs) includes reoxidation of both hemes by CuB. This is in significant contrast to the OH → EH transition of the aa3-type cytochrome oxidase from Paracoccus denitrificans, where the fastest phase is exclusively due to transient reduction of the low-spin heme a, without electron equilibration with the binuclear center. On the other hand, the one-electron reduction of the relaxed O state in ba3 oxidase was similar to that in aa3 oxidase and only included rapid electron transfer from CuA to the low-spin heme b. This indicates a functional difference between the relaxed O and the pulsed OH forms also in the ba3 oxidase from T. thermophilus. 相似文献
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《Journal of Phytopathology》1979,96(3):286-286
Books reviewed in this article Sell, Y., F. Weberling und H. Lorenzen (Herausgeber), Morphologie, Ana-tomie und Systematik der Hoheren Pflanzen. Agrios, George N., Plant Pathology, 2nd Edition. 相似文献