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Predominance of six different hexanucleotide recoding signals 3' of read-through stop codons
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Redefinition of UAG, UAA and UGA to specify a standard amino acid occurs in response to recoding signals present in a minority of mRNAs. This ‘read-through’ is in competition with termination and is utilized for gene expression. One of the recoding signals known to stimulate read-through is a hexanucleotide sequence of the form CARYYA 3′ adjacent to the stop codon. The present work finds that of the 91 unique viral sequences annotated as read-through, 90% had one of six of the 64 possible codons immediately 3′ of the read-through stop codon. The relative efficiency of these read-through contexts in mammalian tissue culture cells has been determined using a dual luciferase fusion reporter. The relative importance of the identity of several individual nucleotides in the different hexanucleotides is complex. 相似文献
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Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3. 总被引:5,自引:0,他引:5
Mingfeng Liu Julian L Leibowitz David A Clark Michael Mendicino Qin Ning Jin Wen Ding Cheryl D'Abreo Laisum Fung Philip A Marsden Gary A Levy 《European journal of biochemistry》2003,270(10):2274-2286