共查询到20条相似文献,搜索用时 15 毫秒
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Background
Abberant aryl hydrocarbon receptor (AhR) expression and AhR pathway activation are involved in gastric carcinogenesis. However, the relationship between AhR pathway activation and gastric cancer progression is still unclear. In present study, we used 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD), a classic and most potent ligand of AhR, to activate AhR pathway and investigated the effect of AhR pathway activation on human gastric cancer AGS cell invasion and explored the corresponding mechanism. 相似文献2.
Jingjing Ye Adam Pavlicek Elizabeth A Lunney Paul A Rejto Chi-Hse Teng 《BMC bioinformatics》2010,11(1):11
Background
Human cancer is caused by the accumulation of tumor-specific mutations in oncogenes and tumor suppressors that confer a selective growth advantage to cells. As a consequence of genomic instability and high levels of proliferation, many passenger mutations that do not contribute to the cancer phenotype arise alongside mutations that drive oncogenesis. While several approaches have been developed to separate driver mutations from passengers, few approaches can specifically identify activating driver mutations in oncogenes, which are more amenable for pharmacological intervention. 相似文献3.
Background
Prostate cancer progression to androgen independence is the primary cause of mortality by this tumor type. The IGF-1/IGF-1R axis is well known to contribute to prostate cancer initiation, but its contribution to invasiveness and the downstream signalling mechanisms that are involved are unclear at present. 相似文献4.
Introduction
In the search for novel cancer biomarkers, various proteolytically derived peptides have been proposed to exhibit cancer or cancer-type specificity. As these peptides are presumably also generated after sample collection by tumor-specific proteases, extensive investigation of the involved proteolytic processes is crucial for further research. 相似文献5.
Marco Sardiello Stefano Cairo Bianca Fontanella Andrea Ballabio Germana Meroni 《BMC evolutionary biology》2008,8(1):225
Background
The TRIM family is composed of multi-domain proteins that display the Tripartite Motif (RING, B-box and Coiled-coil) that can be associated with a C-terminal domain. TRIM genes are involved in ubiquitylation and are implicated in a variety of human pathologies, from Mendelian inherited disorders to cancer, and are also involved in cellular response to viral infection. 相似文献6.
Suzie E Ahn Jin Won Choi Deivendran Rengaraj Hee Won Seo Whasun Lim Jae Yong Han Gwonhwa Song 《Reproductive biology and endocrinology : RB&E》2010,8(1):100
Background
Cysteine cathepsins (CTSs) are involved in the degradation and remodeling of the extracellular matrix and are associated with cell transformation, differentiation, motility, and adhesion. These functions are also related to cancer cell invasion and metastasis. Chickens spontaneously develop epithelial ovarian cancer and are therefore a good animal model for human ovarian cancer. However, no studies have investigated the expression of CTSs in chickens with ovarian cancer. 相似文献7.
LCI modelling approaches applied on recycling of materials in view of environmental sustainability,risk perception and eco-efficiency 总被引:2,自引:0,他引:2
Rolf Frischknecht 《The International Journal of Life Cycle Assessment》2010,15(7):666-671
Purpose and scope
Two ISO-compliant approaches on modelling the recycling of plastics and metals are frequently applied in life cycle assessment case studies and intensively debated: the recycled content or cutoff approach and the end of life recycling or avoided burden approach. This paper discusses the two approaches from three different perspectives: (1) the kind of sustainability concept served, (2) the risk perception involved and (3) the eco-efficiency indicators resulting from the two approaches. 相似文献8.
Barbara Kaltschmidt Ralf A Linker Jinbo Deng Christian Kaltschmidt 《BMC molecular biology》2002,3(1):16-12
Background
NF-κB is implicated in gene regulation involved in neuronal survival, inflammmatory response and cancer. There are relatively few neuronal target genes of NF-κB characterized. 相似文献9.
Background
New approaches are needed for large-scale predictive modeling of cellular signaling networks. While mass action and enzyme kinetic approaches require extensive biochemical data, current logic-based approaches are used primarily for qualitative predictions and have lacked direct quantitative comparison with biochemical models. 相似文献10.
Lennart Martens Geert Monsieur Christophe Ampe Kris Gevaert Joël Vandekerckhove 《BMC bioinformatics》2006,7(1):289-6
Background
Migration is an important aspect of cellular behaviour and is therefore widely studied in cell biology. Numerous components are known to participate in this process in a highly dynamic manner. In order to obtain a better insight in cell migration, mutants or drugs are used and their motive phenotype is then linked with the disturbing factors. One of the typical approaches to study motion paths of individual cells relies on fitting mean square displacements to a persistent random walk function. Since the numerous calculations involved often rely on diverse commercial software packages, the analysis can be expensive, labour-intensive and error-prone work. Additionally, due to the nature of algorithms employed the calculations involved are not readily reproducible without access to the exact software package(s) used. 相似文献11.
Background
Much of the public access cancer microarray data is asymmetric, belonging to datasets containing no samples from normal tissue. Asymmetric data cannot be used in standard meta-analysis approaches (such as the inverse variance method) to obtain large sample sizes for statistical power enrichment. Noting that plenty of normal tissue microarray samples exist in studies not involving cancer, we investigated the viability and accuracy of an integrated microarray analysis approach based on significance analysis of microarrays (merged SAM) using a collection of data from separate diseased and normal samples. 相似文献12.
13.
Anne Ventura 《The International Journal of Life Cycle Assessment》2011,16(2):148-158
Purpose
The classification step is systematically neglected in the calculation of life cycle impact assessment indicators: for several direct contribution of one pollutant to several impact categories, the distribution between these impact categories is not accounted. The proposed approaches of non-redundant classification are based on the probability that an emitted substance and its chemically degraded forms are involved into several environmental impacts. 相似文献14.
Background
Very few analytical approaches have been reported to resolve the variability in microarray measurements stemming from sample heterogeneity. For example, tissue samples used in cancer studies are usually contaminated with the surrounding or infiltrating cell types. This heterogeneity in the sample preparation hinders further statistical analysis, significantly so if different samples contain different proportions of these cell types. Thus, sample heterogeneity can result in the identification of differentially expressed genes that may be unrelated to the biological question being studied. Similarly, irrelevant gene combinations can be discovered in the case of gene expression based classification. 相似文献15.
Haitao Luo Matthew K Daddysman Gary O Rankin Bing-Hua Jiang Yi C Chen 《Cancer cell international》2010,10(1):16
Background
Ovarian cancer is one of the most significant malignancies in the western world. Studies showed that Ovarian cancers tend to grow resistance to cisplatin treatment. Therefore, new approaches are needed in ovarian cancer treatment. Kaempferol is a dietary flavonoid that is widely distributed in fruits and vegetables, and epidemiology studies have revealed a protective effect of kaempferol against ovarian cancer risk. Our early studies also found that kaempferol is effective in reducing vascular endothelial growth factor (VEGF) expression in ovarian cancer cells. In this study, we investigated kaempferol's effects on sensitizing ovarian cancer cell growth in response to cisplatin treatment. 相似文献16.
Tracey Bray Pedro Chan Salim Bougouffa Richard Greaves Andrew J Doig Jim Warwicker 《BMC bioinformatics》2009,10(1):379
Background
The rate of protein structures being deposited in the Protein Data Bank surpasses the capacity to experimentally characterise them and therefore computational methods to analyse these structures have become increasingly important. Identifying the region of the protein most likely to be involved in function is useful in order to gain information about its potential role. There are many available approaches to predict functional site, but many are not made available via a publicly-accessible application. 相似文献17.
Simon van Mourik Aalt DJ van Dijk Maarten de Gee Richard GH Immink Kerstin Kaufmann Gerco C Angenent Roeland CHJ van Ham Jaap Molenaar 《BMC systems biology》2010,4(1):101
Background
The genetic control of floral organ specification is currently being investigated by various approaches, both experimentally and through modeling. Models and simulations have mostly involved boolean or related methods, and so far a quantitative, continuous-time approach has not been explored. 相似文献18.
Carmen Lai Hugo M Horlings Marc J van de Vijver Eric H van Beers Petra M Nederlof Lodewyk FA Wessels Marcel JT Reinders 《BMC bioinformatics》2007,8(1):422
Background
Array comparative genome hybridization (aCGH) provides information about genomic aberrations. Alterations in the DNA copy number may cause the cell to malfunction, leading to cancer. Therefore, the identification of DNA amplifications or deletions across tumors may reveal key genes involved in cancer and improve our understanding of the underlying biological processes associated with the disease. 相似文献19.
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