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Genetic Recombination Between Stromal and Cancer Cells Results in Highly Malignant Cells Identified by Color‐Coded Imaging in a Mouse Lymphoma Model
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Miki Nakamura Atsushi Suetsugu Kousuke Hasegawa Takuro Matsumoto Hitomi Aoki Takahiro Kunisada Masahito Shimizu Shigetoyo Saji Hisataka Moriwaki Robert M. Hoffman 《Journal of cellular biochemistry》2017,118(12):4216-4221
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《Redox report : communications in free radical research》2013,18(4):161-171
AbstractYeast flavohemoglobin (Yhb1p) plays a pivotal role in NO? detoxification and has also been implicated in oxidative/reductive stress responses. In this study, we have used a YHB1-GFP reporter expressing a full-length chromosome-tagged Yhb1-GFP fusion protein to monitor changes in flavohemoglobin levels after cell treatment with oxidants, antioxidants and nitric oxide donors. Only nitric oxide donors were found to induce a dose-dependent increase in Yhb1-GFP expression while hydrogen peroxide, menadione and diamide caused a moderate diminution of YHB1-GFP fluorescence. Additionally, the levels of endogenous and hydroperoxide-induced ROS production in the Δyhb1 mutant were comparable to those in the isogenic wild-type strain. Although peroxides increased NO? generation while nitrite and nitric oxide donors augmented ROS levels in yeast cells, their effects were generally not more pronounced in Δyhb1 than in wild-type cells. Taken together, these data suggest that yeast flavohemoglobin does not contribute to cross-protection against oxidative and nitrosative stress. 相似文献
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Marta Czernik Antonella Fidanza Martina Sardi Cesare Galli Dario Brunetti Daniela Malatesta Leonardo Della Salda Kazutsugu Matsukawa Grazyna E. Ptak Pasqualino Loi 《Journal of cellular biochemistry》2013,114(1):134-143
Mesenchymal stem cells (MSCs) are an important cell population in the bone marrow microenvironment. MSCs have the capacity to differentiate in vitro into several mesenchymal tissues including bone, cartilage, fat, tendon, muscle, and marrow stroma. This study was designed to isolate, expand, and characterize the differentiation ability of sheep bone marrow‐derived MSCs and to demonstrate the possibility to permanently express a reporter gene. Bone marrow was collected from the iliac crest and mononuclear cells were separated by density gradient centrifugation. Sheep MSCs cell lines were stable characterized as CD44+ and CD34? and then transfected with a green fluorescent protein (GFP) reporter gene. The GFP expression was maintained in about half (46.6%) of cloned blastocysts produced by nuclear transfer of GFP+ sheep MSCs, suggesting the possibility to establish multipotent embryonic cells' lines carrying the fluorescent tag for comparative studies on the differentiation capacity of adult stem cells (MSCs) versus embryonic stem cells. We found that sheep MSCs under appropriate culture conditions could be induced to differentiate into adipocytes, chondrocytes, and osteoblast lineages. Our results confirm the plasticity of sheep MSCs and establish the foundation for the development of a pre‐clinical sheep model to test the efficiency and safety of cell replacement therapy. J. Cell. Biochem. 114: 134–143, 2012. © 2012 Wiley Periodicals, Inc. 相似文献
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Labeling the Stroma of a Patient‐Derived Orthotopic Xenograft (PDOX) Mouse Model of Undifferentiated Pleomorphic Soft‐Tissue Sarcoma With Red Fluorescent Protein for Rapid Non‐Invasive Imaging for Drug Screening
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Tasuku Kiyuna Takashi Murakami Yasunori Tome Kentaro Igarashi Kei Kawaguchi Tara Russell Mark A. Eckardt Joseph Crompton Arun Singh Nicholas Bernthal Susan Bukata Noah Federman Fuminori Kanaya Fritz C. Eilber Robert M. Hoffman 《Journal of cellular biochemistry》2017,118(2):361-365
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Analysis of Stroma Labeling During Multiple Passage of a Sarcoma Imageable Patient‐Derived Orthotopic Xenograft (iPDOX) in Red Fluorescent Protein Transgenic Nude Mice
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Tasuku Kiyuna Takashi Murakami Yasunori Tome Kei Kawaguchi Kentaro Igarashi Kentaro Miyake Fuminori Kanaya Arun Singh Fritz C. Eilber Robert M. Hoffman 《Journal of cellular biochemistry》2017,118(10):3367-3371
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3‐Dimensional Tissue Is Formed From Cancer Cells In Vitro on Gelfoam®, But Not on MatrigelTM
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Yasunori Tome Fuminari Uehara Sumiyuki Mii Shuya Yano Lei Zhang Naotoshi Sugimoto Hiroki Maehara Michael Bouvet Hiroyuki Tsuchiya Fuminori Kanaya Robert M. Hoffman 《Journal of cellular biochemistry》2014,115(8):1362-1367
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Enhanced Metastatic Recurrence Via Lymphatic Trafficking of a High‐Metastatic Variant of Human Triple‐Negative Breast Cancer After Surgical Resection in Orthotopic Nude Mouse Models
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Shuya Yano Kiyoto Takehara Hiroshi Tazawa Hiroyuki Kishimoto Shunsuke Kagawa Michael Bouvet Toshiyoshi Fujiwara Robert M. Hoffman 《Journal of cellular biochemistry》2017,118(3):559-569
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Peripheral Lipopolysaccharide Challenge Induces Long‐Term Changes in Tyrosine Hydroxylase Regulation in the Adrenal Medulla
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Lin Kooi Ong Scott Page Gabrielle D. Briggs Liying Guan Matthew D. Dun Nicole M. Verrills Peter R. Dunkley Phillip W. Dickson 《Journal of cellular biochemistry》2017,118(8):2096-2107
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A Carboxy Terminal BMP/TGF‐β Binding Site in Secreted Phosphoprotein 24 kD Independently Affects BMP‐2 Activity
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Haijun Tian Chen‐Shuang Li Ke‐Wei Zhao Jeffrey C. Wang M. Eugenia L. Duarte Cynthia L. David Kevin Phan Elisa Atti Elsa J. Brochmann Samuel S. Murray 《Journal of cellular biochemistry》2015,116(4):667-676
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