共查询到20条相似文献,搜索用时 15 毫秒
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Knockdown of Long Non‐Coding RNA‐ZFAS1 Protects Cardiomyocytes Against Acute Myocardial Infarction Via Anti‐Apoptosis by Regulating miR‐150/CRP 下载免费PDF全文
Tao Wu Dan Wu Qinghua Wu Bing Zou Xiao Huang Xiaoshu Cheng Yanqing Wu Kui Hong Ping Li Renqiang Yang Yunde Li Yingzhang Cheng 《Journal of cellular biochemistry》2017,118(10):3281-3289
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Su Yeon Jeon Hyun‐Jung Lee Kyu‐Hwan Na Dong‐Hyun Cha Jin Kyeoung Kim Jong‐Wan Park Tae Ki Yoon Gi Jin Kim 《Journal of cellular biochemistry》2013,114(1):89-98
The regulation of trophoblast apoptosis is essential for normal placentation, and increased placental trophoblast cell apoptosis is the cause of pathologies such as intrauterine growth retardation (IUGR) and pre‐eclampsia. X‐linked inhibitor of apoptosis (XIAP) is expressed in trophoblasts, but little is known about the role of XIAP in placental development. In the present study, the function of XIAP in the placenta and in HTR‐8/SVneo trophoblasts under hypoxic conditions was examined. In addition, the correlation between XIAP and immortalization‐upregulated protein‐2 (IMUP‐2) was demonstrated in HTR‐8/SVneo trophoblasts under hypoxia, based on a previous study showing that increased IMUP‐2 induces trophoblast apoptosis and pre‐eclampsia. XIAP was downregulated in pre‐eclamptic placentas (P < 0.05). In HTR‐8/SVneo trophoblasts, XIAP expression was decreased and the expression of apoptosis‐related genes was increased in response to hypoxia. Ectopic expression of hypoxia inducible factor (HIF)‐1α in HRT‐8 SV/neo cells induced the nuclear translocation of XIAP and alterations of XIAP protein stability. Furthermore, hypoxia induced nuclear translocated XIAP co‐localized with upregulated IMUP‐2 in trophoblast nuclei, and the interaction between XIAP and IMUP‐2 induced apoptosis in HRT‐8 SV/neo cells. The present results suggest that hypoxia‐induced down‐regulation of XIAP mediates apoptosis in trophoblasts through interaction with increased IMUP‐2, and that this mechanism underlies the pathogenesis of pre‐eclampsia. J. Cell. Biochem. 114: 89–98, 2012. © 2012 Wiley Periodicals, Inc. 相似文献
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c‐Src,Insulin‐Like Growth Factor I Receptor,G‐Protein‐Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes 下载免费PDF全文
Rachel M. DeRita Brad Zerlanko Amrita Singh Huimin Lu Renato V. Iozzo Jeffrey L. Benovic Lucia R. Languino 《Journal of cellular biochemistry》2017,118(1):66-73
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All‐Trans‐Retinoic Acid Stimulates Overexpression of Tumor Protein D52 (TPD52, Isoform 3) and Neuronal Differentiation of IMR‐32 Cells 下载免费PDF全文
Sudha Sravanti Kotapalli Chandrashekhar Dasari Divya Duscharla Karthik Reddy Kami Reddy Manjula Kasula Ramesh Ummanni 《Journal of cellular biochemistry》2017,118(12):4358-4369
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Bombesin Receptor‐Activated Protein (BRAP) Modulates NF‐κB Activation in Bronchial Epithelial Cells by Enhancing HDAC Activity 下载免费PDF全文
Ying Liu Xiao‐Qun Qin Horst Christian Weber Yang Xiang Chi Liu Hui‐Jun Liu Huan Yang Jianxin Jiang Xiangping Qu 《Journal of cellular biochemistry》2016,117(5):1069-1077
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Genetic Recombination Between Stromal and Cancer Cells Results in Highly Malignant Cells Identified by Color‐Coded Imaging in a Mouse Lymphoma Model 下载免费PDF全文
Miki Nakamura Atsushi Suetsugu Kousuke Hasegawa Takuro Matsumoto Hitomi Aoki Takahiro Kunisada Masahito Shimizu Shigetoyo Saji Hisataka Moriwaki Robert M. Hoffman 《Journal of cellular biochemistry》2017,118(12):4216-4221