共查询到20条相似文献,搜索用时 15 毫秒
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Something about SUMO inhibits transcription 总被引:1,自引:0,他引:1
Gill G 《Current opinion in genetics & development》2005,15(5):536-541
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Bassuk AG Barton KP Anandappa RT Lu MM Leiden JM 《Molecular medicine (Cambridge, Mass.)》1998,4(6):392-401
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Watts FZ 《Seminars in cell & developmental biology》2004,15(2):211-220
A wide range of eukaryotic proteins has been shown to be sumoylated. Most, but not all of these proteins are nuclear. In all cases documented so far, sumoylation has been shown to occur on lysine residues. In general these are located within the consensus sequence psiKxE, although there are some exceptions to this. The role of sumoylation has been investigated for a number of identified targets. Unlike the situation with ubiquitination, sumoylation does not appear to target proteins for proteasome-mediated degradation. In contrast, the effect of SUMO modification appears to depend on the target protein and includes roles in altering protein activity, protein-protein interactions or protein localisation. 相似文献
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P300 transcriptional repression is mediated by SUMO modification 总被引:7,自引:0,他引:7
Girdwood D Bumpass D Vaughan OA Thain A Anderson LA Snowden AW Garcia-Wilson E Perkins ND Hay RT 《Molecular cell》2003,11(4):1043-1054
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