共查询到20条相似文献,搜索用时 31 毫秒
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Casola A Burger N Liu T Jamaluddin M Brasier AR Garofalo RP 《The Journal of biological chemistry》2001,276(23):19715-19722
Respiratory syncytial virus (RSV) produces intense pulmonary inflammation, in part, through its ability to induce chemokine synthesis in infected airway epithelial cells. RANTES (regulated upon activation, normal T-cells expressed and secreted) is a CC chemokine which recruits and activates monocytes, lymphocytes, and eosinophils, all cell types present in the lung inflammatory infiltrate induced by RSV infection. In this study we investigated the role of reactive oxygen species in the induction of RANTES gene expression in human type II alveolar epithelial cells (A549), following RSV infection. Our results indicate that RSV infection of airway epithelial cells rapidly induces reactive oxygen species production, prior to RANTES expression, as measured by oxidation of 2',7'-dichlorofluorescein. Pretreatment of airway epithelial cells with the antioxidant butylated hydroxyanisol (BHA), as well a panel of chemically unrelated antioxidants, blocks RSV-induced RANTES gene expression and protein secretion. This effect is mediated through the ability of BHA to inhibit RSV-induced interferon regulatory factor binding to the RANTES promoter interferon-stimulated responsive element, that is absolutely required for inducible RANTES promoter activation. BHA inhibits de novo interferon regulator factor (IRF)-1 and -7 gene expression and protein synthesis, and IRF-3 nuclear translocation. Together, these data indicates that a redox-sensitive pathway is involved in RSV-induced IRF activation, an event necessary for RANTES gene expression. 相似文献
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Paludan SR Malmgaard L Ellermann-Eriksen S Boscá L Mogensen SC 《European cytokine network》2001,12(2):297-308
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Lefebvre S Berrih-Aknin S Adrian F Moreau P Poea S Gourand L Dausset J Carosella ED Paul P 《The Journal of biological chemistry》2001,276(9):6133-6139
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Gamma interferon triggers interaction between ICSBP (IRF-8) and TEL,recruiting the histone deacetylase HDAC3 to the interferon-responsive element
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Kuwata T Gongora C Kanno Y Sakaguchi K Tamura T Kanno T Basrur V Martinez R Appella E Golub T Ozato K 《Molecular and cellular biology》2002,22(21):7439-7448
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Ruiz-Ruiz C Ruiz de Almodóvar C Rodríguez A Ortiz-Ferrón G Redondo JM López-Rivas A 《The Journal of biological chemistry》2004,279(19):19712-19720
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Wietek C Miggin SM Jefferies CA O'Neill LA 《The Journal of biological chemistry》2003,278(51):50923-50931
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