共查询到20条相似文献,搜索用时 0 毫秒
1.
《Molecular cell》2021,81(16):3386-3399.e10
2.
3.
4.
5.
ELL-associated protein 30 (EAP30) was initially characterized as a component of the Holo-ELL complex, which contains the elongation factor ELL. Both ELL and Holo-ELL stimulate RNA pol II elongation in vitro. However, ELL and not Holo-ELL inhibits RNA pol II initiation. It is not clear how these two discrete functions of ELL are regulated. Here we report that mini-chromosome maintenance 2 (MCM2) binds to EAP30 and show that MCM2 competes with ELL for binding to EAP30 thus potentially modulating the stability of Holo-ELL.
Structured summary
MINT-7277033: EAP30 (uniprotkb:Q96H20) physically interacts (MI:0915) with RPB1 (uniprotkb:P24928) by anti tag coimmunoprecipitation (MI:0007)MINT-7277085: EAP30 (uniprotkb:Q96H20) binds (MI:0407) to ELL (uniprotkb:P55199) by pull down (MI:0096)MINT-7277072: EAP30 (uniprotkb:Q96H20) physically interacts (MI:0915) with ELL (uniprotkb:P55199) by anti tag coimmunoprecipitation (MI:0007)MINT-7277100: EAP30 (uniprotkb:Q96H20) physically interacts (MI:0915) with ELL (uniprotkb:P55199) by competition binding (MI:0405)MINT-7277153: MCM2 (uniprotkb:P49736) binds (MI:0407) to ELL (uniprotkb:P55199) by pull down (MI:0096)MINT-7276989: EAP30 (uniprotkb:Q96H20) physically interacts (MI:0915) with MCM2 (uniprotkb:P49736) by pull down (MI:0096)MINT-7277005: EAP30 (uniprotkb:Q96H20) physically interacts (MI:0915) with RPB1 (uniprotkb:P24928) by pull down (MI:0096)MINT-7276960, MINT-7277168: MCM2 (uniprotkb:P49736) physically interacts (MI:0915) with EAP30 (uniprotkb:Q96H20) by two hybrid (MI:0018)MINT-7276971, MINT-7277121, MINT-7277137: MCM2 (uniprotkb:P49736) binds (MI:0407) to EAP30 (uniprotkb:Q96H20) by pull down (MI:0096)MINT-7277018, MINT-7277061: EAP30 (uniprotkb:Q96H20) physically interacts (MI:0915) with MCM2 (uniprotkb:P49736) by anti tag coimmunoprecipitation (MI:0007) 相似文献6.
Hemming SA Jansma DB Macgregor PF Goryachev A Friesen JD Edwards AM 《The Journal of biological chemistry》2000,275(45):35506-35511
7.
Wei W Dorjsuren D Lin Y Qin W Nomura T Hayashi N Murakami S 《The Journal of biological chemistry》2001,276(15):12266-12273
8.
9.
10.
11.
12.
TFIIB and the regulation of transcription by RNA polymerase II 总被引:2,自引:0,他引:2
13.
14.
15.
Assembly and disassembly of the Drosophila RNA polymerase II complex during transcription. 总被引:11,自引:0,他引:11
J T Kadonaga 《The Journal of biological chemistry》1990,265(5):2624-2631
16.
17.
18.
O Flores E Maldonado Z Burton J Greenblatt D Reinberg 《The Journal of biological chemistry》1988,263(22):10812-10816
19.