共查询到20条相似文献,搜索用时 15 毫秒
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Seymour M 《Alternatives to laboratory animals : ATLA》2010,38(Z1):15-20
This paper is an overview of the applications of the technique of Accelerator Mass Spectrometry (AMS) in the biomedical drug development field. The work described here has been carried out at Xceleron (York, UK and Germantown, MD, USA), and it aims to apply AMS to provide better information about the human pharmacokinetic/metabolic behaviour of drugs or drug candidates as early as possible. It is hoped that the use of this technique will contribute to the delivery of better, more effective drugs onto the market sooner, which will be good news for all concerned. 相似文献
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Rob Bugter Paula Harrison John Haslett Rob Tinch 《Biodiversity and Conservation》2018,27(7):1549-1560
This Editorial to the BESAFE special issue introduces the project and its approach and case studies. The BESAFE (EC 7th Framework programme) project investigated how the effectiveness of different types of arguments for biodiversity conservation depends on the context in which they are used. Our results show that tailoring of argumentation to audience within the course of decision processes is the main factor determining effectiveness. We consistently found arguments linked to intrinsic value (e.g. moral or ethical obligation arguments) as shared and supported widely, and thus offering common ground between parties. Economic arguments are effective as additional ones, but not as replacements. Next generation biodiversity conservation strategies can probably improve their effectiveness by emphasizing and better explaining the synergies between traditional conservation and especially regulating and cultural services. 相似文献
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E. F. Hvidberg 《BMJ (Clinical research ed.)》1989,299(6699):580-581
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Denecke J Aniento F Frigerio L Hawes C Hwang I Mathur J Neuhaus JM Robinson DG 《The Plant cell》2012,24(4):1316-1326
Transient gene expression, in plant protoplasts or specific plant tissues, is a key technique in plant molecular cell biology, aimed at exploring gene products and their modifications to examine functional subdomains, their interactions with other biomolecules, and their subcellular localization. Here, we highlight some of the major advantages and potential pitfalls of the most commonly used transient gene expression models and illustrate how ectopic expression and the use of dominant mutants can provide insights into protein function. 相似文献
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《FEBS letters》2001,490(3):109-208