共查询到20条相似文献,搜索用时 7 毫秒
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C Reisner 《BMJ (Clinical research ed.)》1987,294(6576):905-906
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Stephen E Roberts John G Williams David Yeates Michael J Goldacre 《BMJ (Clinical research ed.)》2007,335(7628):1033
Objective To compare mortality outcomes in the three years after elective colectomy, no colectomy, and emergency colectomy among people admitted to hospital for inflammatory bowel disease, to inform whether the threshold for elective colectomy in clinical practice is appropriate.Design Record linkage studies.Setting Oxford region (1968-99) and England (1998-2003).Participants 23 464 people with hospital stay for more than three days for inflammatory bowel disease, including 5480 who had colectomy.Main outcome measures Case fatality, relative survival, and standardised mortality ratios.Results In the Oxford region, three year mortality was lower after elective colectomy than after either no colectomy or emergency colectomy, although this was not significant. For England, mortality three years after elective colectomy for ulcerative colitis (3.7%) and Crohn''s disease (3.3%) was significantly lower than that after either admission without colectomy (13.6% and 10.1%; both P<0.001) or emergency colectomy (13.2% and 9.9%; P<0.001 for colitis and P<0.01 for Crohn''s disease). Three or more months after elective colectomy, mortality was similar to that in the general population. Adjustment for comorbidity did not affect the findings.Conclusions In England, the clinical threshold for elective colectomy in people with inflammatory bowel disease may be too high. Further research is now required to establish the threshold criteria and optimal timing of elective surgery for people with poorly controlled inflammatory bowel disease. 相似文献
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A randomised trial of the treatment of hypertension in 884 patients aged 60 to 79 years at the onset showed a reduction of 18/11 mm Hg in blood pressure over a mean follow up period of 4.4 years. The principal antihypertensive agents were atenolol and bendrofluazide. There was a reduction in the rate of fatal stroke in the treatment group to 30% of that in the control group (95% confidence interval 11-84%, p less than 0.025). The rate of all strokes (fatal and non-fatal) in the treatment group was 58% of that in the control group (95% confidence interval 35-96%, p less than 0.03). The incidence of myocardial infarction and total mortality was unaffected by treatment. Questionnaires completed by the patients and their relatives failed to identify any differences in symptoms that were likely to be due to treatment. 相似文献
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K Morgan 《BMJ (Clinical research ed.)》1982,284(6316):664-665
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A J Tulloch 《BMJ (Clinical research ed.)》1981,282(6277):1672-1675
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Mukund A. Prabhu Narayanan Namboodiri Srinivas Prasad BV S.P. Abhilash Anees Thajudeen Kumar V.K. Ajith 《Indian pacing and electrophysiology journal》2015,15(6):286-290