Pericarditis,pleural effusion,and pneumonitis with transient mitochondrial antibodies.

Four women with fever, arthromyalgias, pericarditis, pleural effusion, high erythrocyte sedimentation rates, and lymphopenia had mitochondrial antibodies in the serum in the absence of antinuclear antibody. Their illness lasted 5-12 weeks and the antibody test results became negative on remission. Absence of specific bacteriological findings, normal antistreptolysin O titres, resistance to antibiotics, and good response to steroids suggested that these cases represented a milder and less persistent form of the syndrome resembling systemic lupus erythematosus described by German authors.     

中国四川和宁夏巨须隐翅虫亚属的新种和新纪录(鞘翅目,隐翅虫科,巨须隐翅虫亚科)

报道中国四川和宁夏巨须隐翅虫属Oxyporus Fablicius,巨须隐翅虫亚属subgenus Oxyporus12个种.记述了 4新种,黄缘巨须隐翅虫Oxyporus aureomarginatus,北川巨须隐翅虫O.beichuanus,海螺沟巨须隐翅虫O.hailuogou和肩斑巨须隐翅虫O.humerosus.简述了1新亚种,扬氏高山巨须隐翅虫O.altus yangae的特征.首次记述了黑胸巨须隐翅虫O.nigricollis Zheng的雄性.提供了高山巨须隐翅虫Oxyporus altus Huang,Zhao et Li,仙台巨须隐翅虫O.germanus Sharp,黑腹蕈巨须隐翅虫O.humerocroceus Huang,Zhao et Li,溪巨须隐翅虫O.riparius Zheng,橘红巨须隐翅虫O.rufus(Linné),中华巨须隐翅虫O.sinicus Huang,Zhao et Li,和横沟巨须隐翅虫O.transversesrlcatus Bernhauer的新分布.所有研究标本都附有彩色整体外形图,新种和新的雄性配有特征图.     

New species and host records of New World,mostly Neotropical,opiine Braconidae (Hymenoptera) reared from flower-infesting,stem-galling,and stem-mining Tephritidae (Diptera)

New host records (all members of the family Tephritidae) are presented for 14 newly described species of opiine Braconidae from the neotropics and two previously described species, one from the neotropics and one from the Nearctic Region. Doryctobracon anneae Wharton, Opius baderae Wharton, O. baeblus Wharton, O. cablus Wharton, O. dablus Wharton, O. danielsae Wharton, O. gabriellae Wharton, O. godfrayi Wharton, O. marshi Wharton, O. nablus Wharton, O. pipitae Wharton, O. stecki Wharton, O. taramegillae Wharton, and O. yoderi Wharton are newly described. Hosts are newly recorded for the previously described species Opius nympha Fischer and O. peleus Fischer. A key is presented to Opiinae that have been reared from flower, stem, and leaf feeding tephritids in the New World. Host and host plant associations are discussed; a few of the tephritid host plant records are also new. Opius cosa (Fischer), is a comb. n.     

圆丘直角步甲种名修订及印度尼西亚直角步甲属二新种记述(鞘翅目,步甲总科,直角步甲族)

简述了印度尼西亚圆丘直角步甲Orthogonius inops Chaudoir并确定同产于哈马黑拉岛（Halmahera)的O.aeq-uistrialus Jordan为其新异名（syn.nov)，记述了产于苏拉威西岛（Sulawesi)的直角步甲属2新种；苏岛直角步甲O.sulawesicus sp.nov和里氏直角步甲O.ribbei sp.nov。上述模式标本均保存在法国国家自然历史博物馆。     

Microencephalic nanism, severe retardation, hypertonia, obesity, and hypogonadism in two brothers: a new syndrome?

Two brothers are described with a severe syndrome of postnatal growth and mental retardation which includes extreme microcephaly, obesity developing during infancy, microgonadismsm, and a characteristic amphora-shaped facies. The neurological exam is highly abnormal, with hypertonia and hyperreflexia, nystagmus, and an extremely irritable and agitated behavior. The first child, who died at 4/1/2 years, also presented neonatal hypoglycemia and chronic constipation. Although the etiology of this syndrome is unknown, it is tempting to consider an X-linked recessive gene, given the importance of the X chromosome in mental retardation. Among the over 70 syndromes of X-linked mental retardation already described, our patients resemble individuals with the B?rjeson-Forssman-Lehmann (BFL) syndrome the most. However, the severity of their dwarfism and mental retardation is much greater than described in any BFL patient to date, and the neurological and dysmorphic features vary significantly from those described in the BFL. Although a particularly severe variant, perhaps allelic, is a possibility, an as yet undescribed disorder is also plausible, the etiology of which would probably be recessive, either autosomal or X-linked.     

中国四川巨须隐翅虫亚属二新种(鞘翅目,隐翅虫科,巨须隐翅虫亚科)

报道中国四川巨须隐翅虫属Oxyporus Fablicius,巨须隐翅虫亚属subgenus Oxyporus的5个种,其中包括2新种,美姑巨须隐翅虫Oxyporus(Oxyporus) meigu sp.nov.和闫氏巨须隐翅虫O.(O.) yanae sp.nov.,补充了溪巨须隐翅虫O.riparius Zheng,横沟巨须隐翅虫O.transversesulcatus Bernhauer 和黑胸巨须隐翅虫O.nigricollis Zheng新的地理分布.     

StcE,a metalloprotease secreted by Escherichia coli O157:H7, specifically cleaves C1 esterase inhibitor

Escherichia coli O157:H7 causes diarrhoea, haemorrhagic colitis, and the haemolytic uraemic syndrome. We have identified a protein of previously unknown function encoded on the pO157 virulence plasmid of E. coli O157:H7, which is the first described protease that specifically cleaves C1 esterase inhibitor (C1-INH), a member of the serine protease inhibitor family. The protein, named StcE for secreted protease of C1 esterase inhibitor from EHEC (formerly Tagn), cleaves C1-INH to produce (unique) approximately 60-65 kDa fragments. StcE does not digest other serine protease inhibitors, extracellular matrix proteins or universal protease targets. We also observed that StcE causes the aggregation of cultured human T cells but not macrophage-like cells or B cells. Substitution of aspartic acid for glutamic acid at StcE position 435 within the consensus metalloprotease active site ablates its abilities to digest C1-INH and to aggregate T cells. StcE is secreted by the etp type II secretion pathway encoded on pO157, and extracellular StcE levels are positively regulated by the LEE-encoded regulator, Ler. StcE antigen and activity were detected in the faeces of a child with an E. coli O157:H7 infection, demonstrating the expression of StcE during human disease. Cleavage of C1-INH by StcE could plausibly cause localized pro-inflammatory and coagulation responses resulting in tissue damage, intestinal oedema and thrombotic abnormalities.     

Shallow water rissoiform gastropods from Tristan da Cunha, South Atlantic Ocean, with records of species from Gough Island

Shallow water rissoiform gastropods collected by the Norwegian Scientific Expedition (1937-1938) to Tristan da Cunha are described. The fauna consists of Powellisefia cf. philomelae (Watson) (Rissoidae), three new species of Eatoniella, E. trochiformisa, E. lineuta , and E. tristanensis (Eatoniellidae). two new species of Onoba, O. crassicordara and O. tristanensis (Rissoidae) and Rissoella cf. irma (Bartsch) (Rissoellidae). A small collection from Cough Island is also described, containing three species referred to Onoha , one of which is described as new. O. merelinoides , and a species of Eutoniella. The biogeographie relationships of the fauna are briefly discussed.     

斯里兰卡直角步甲属三新种及一新纪录种(鞘翅目,步甲总科,直角步甲族)

描述了斯里兰卡步甲总科直角步甲属3新种：斯直角步甲O．srilankaicus sp．nov．,贝氏直角步甲O．batesi sp．nov．和卵形直角步甲O．ovatulus sp．nov．。股直角步甲O．femoralis Chaudoir为斯里兰卡新纪录种。     

中国巨须隐翅虫属六新种(鞘翅目,隐翅虫科,巨须隐翅虫亚科)

记述中国巨须隐翅虫属 Oxporus Fablicius 6新种,其中,刘氏巨须隐翅虫 Oxyporus(Oxporus)liuae sp.nov.,狭巨须隐翅虫O.(O.)angustatrs sp.nov.,二郎山巨须隐翅虫O.(O.)erlangshanus sp nov.和黑腹巨须隐翅虫O.(O.)atratulus sp.nov.来自四川,双带巨须隐翅虫O.(O.)bifasciarius sp.nov.和黄腿巨须隐翅虫O.(O.).femoratus sp.nov.采至云南.编制了中国已知种检索表.     

New, partially hydrolyzable synthetic analogues of lecithin, phosphatidyl ethanolamine, and phosphatidic acid

The synthesis of two new synthetic analogues of lecithin, two of phosphatidyl ethanolamine ("cephalin"), and one new phosphatidic acid analogue is described. They comprise one of each of the following types: the "isosteric" diether lecithin and cephalin analogues ROCH(2)CH(OR)- CH(2)CH(2)P(O) (O(-))OCH(2)CH(2)N(+)R'(3) (R = C(18)H(37); R' = H or CH(3)); and the "hydrocarbon" analogues of phosphatidic acid, lecithin, and cephalin, C(17)H(35)CH(2)CH(C(18)H(37))CH(2)P(O)(R) = (R'); [R = R' = OH; R = O(-), R' = OCH(2)CH(2)N(+)(CH(3))(3); and R = O(-), R' = OCH(2)CH(2)N(+)H(3)]. Infrared spectra and other properties of these compounds are described.     

中国云南巨须隐翅虫亚属的新种和新纪录(鞘翅目,隐翅虫科,巨须隐翅虫亚科)(英文)

报道中国云南巨须隐翅虫属Oxyporus Fablicius和巨须隐翅虫亚属subgenus Oxyporus的4个种,其中包括2新种,玉龙巨须隐翅虫Oxyporus (Oxyporus) yulong sp.nov.和李氏巨须隐翅虫O.(O.)lii sp.nov.,补充了仙台巨须隐翅虫O.germanus Sharp和横沟巨须隐翅虫O.transversesulcatus Bernhauer新的地理分布。     

Siluro-devonian Conodonts from the Camelford Limestone, Wellington, New South Wales, Australia

Conodont data have been utilized to identify the Silurian/Devonian boundary within the Camelford Limestone near Wellington, NSW. Conodont faunas are documented from the eosteinhornensis Zone to early delta Zone with one new species of Walliserodus ( W. multistriatus ) and two new species of Ozarkodina ( O. brocki and O. camelfordensis ) described. An apparatus reconstruction of Belodella anomalis is also presented.     

A syndrome of congenital ichthyosis, hypogonadism, small stature, facial dysmorphism, scoliosis and myogenic dystrophy

Rud syndrome formerly was considered as a genetically heterogeneous but distinct clinical entity with the manifestations of ichtyosis, hypogonadism, small stature, mental retardation, epilepsy and, infrequently, retinitis pigmentosa. The existence of such a syndrome has recently been dismissed based on a new understanding of the ichthyoses. We report on the clinical history of a 14-year-old boy with congenital ichthyosis, small stature, hypogonadism, facial dysmorphism, nystagmus, kypho-scoliosis and myogenic dystrophy. He was diagnosed as Rud syndrome but developed neither seizures nor mental retardation. However a cousin was mentally retarded. The ichthyosis was familial as five relatives had ichthyosis but no other features of Rud syndrome. The patient had a deletion of the steroid-sulfatase gene. He had neither chondrodysplasia punctata, nor Kallmann syndrome, two conditions which are part of the contiguous gene syndrome of the Xp22.3 region. Most case reports previously reported as Rud syndrome can now be reassigned under a contemporary ichthyosis classification that does not include Rud syndrome as a distinct entity. This case was clearly distinct from Refsum disease, Sj?gren-Larsson syndrome and any of the other ichthyosis disorders that have been suggested as a replacement for Rud syndrome. Thus the case reported here appears distinct from any previously described, currently recognized syndrome.     

新加坡及泰国南部直角步甲属三新种记述（鞘翅目：步甲总科）

本文记述新加坡和泰国南部产直角步甲族直角步甲属3新种。 1. 壮须直角步甲Orthogonius solidicornis, 新种 (图1～5) 　　正模 ♂,标签为“Singapore Seletar Reservoir, 1°42′N, 103°48′E, 07-Ⅹ-1991, O. Martin leg","Zoologisk Museum, Copenhagen"和“Orthogonius sp. l"(Morvan 先生初步鉴定),保存于丹麦哥本哈根博物馆。 　　本新种触角短,头及前胸背板具刻点,前胸背板后角阔,鞘翅第3行距无毛穴,雄性阳具中叶粗壮,易与本属其它种相区别。 2. 泰直角步甲Orthogonius thaicus, 新种 (图6～10) 　　正模 ♂,标签为“Thailand Satum Province, Thale Ban National Park, 4°42′N,100°10′E, 22～24-Ⅹ-1991, O. Martin leg", "Zoologisk Museum Copenhagen", Morvan 先生的初步鉴定标签为“Orthogonius sp. 2"及“ssp. de. Or. angustus Chaud."; 副模 1♀,"Thailand Satum Province, Thale Ban National Park, 4°42′N, 100°10′E, 22～24-Ⅹ-1991, O. Martin leg","Zoologisk Museum Copenhagen"; 1♀, "Thailand Satum Province, Thale Ban National Park, 4°42′N, 100°10′E, 18～20-Ⅹ-1991, O. Martin leg","Zoologisk Museum Copenhagen"。正模保存于丹麦哥本哈根博物馆,1副模由Morvan 先生收藏(法国Carentoire),另1副模保存在中国广州华南农业大学。 　　本新种相似于O. angustus Chaudoir, 但其体色更暗,唇基4刚毛,雄虫第7腹板略凹入,雄虫阳具中叶稍粗,可与后者区别。 3. 莫氏直角步甲Orthogonius morvani, 新种 (图11～15) 　　正模 ♂,标签为“Thailand Satum Province, Thale Ban National Park, 4°42′N,100°10′E, 22～24-Ⅹ-1991, O. Martin leg", "Zoologisk Museum Copenhagen"和“Orthognius sp. l"(Morvan 先生初步鉴定);副模1♀,同正模。正模和副模分别保存于丹麦哥本哈根博物馆和中国广州华南农业大学。 　　本新种与产于缅甸的O. dispar Bates 很相近,但其雄虫第7腹板中央深凹,鞘翅近端部圆截,且雄性阳具中叶形状与后者明显不同。     

Association of Nucleotide Polymorphisms within the O-Antigen Gene Cluster of Escherichia coli O26, O45, O103, O111, O121, and O145 with Serogroups and Genetic Subtypes

Shiga toxin-producing Escherichia coli (STEC) strains are important food-borne pathogens capable of causing hemolytic-uremic syndrome. STEC O157:H7 strains cause the majority of severe disease in the United States; however, there is a growing concern for the amount and severity of illness attributable to non-O157 STEC. Recently, the Food Safety and Inspection Service (FSIS) published the intent to regulate the presence of STEC belonging to serogroups O26, O45, O103, O111, O121, and O145 in nonintact beef products. To ensure the effective control of these bacteria, sensitive and specific tests for their detection will be needed. In this study, we identified single nucleotide polymorphisms (SNPs) in the O-antigen gene cluster that could be used to detect STEC strains of the above-described serogroups. Using comparative DNA sequence analysis, we identified 22 potentially informative SNPs among 164 STEC and non-STEC strains of the above-described serogroups and designed matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF) assays to test the STEC allele frequencies in an independent panel of bacterial strains. We found at least one SNP that was specific to each serogroup and also differentiated between STEC and non-STEC strains. Differences in the DNA sequence of the O-antigen gene cluster corresponded well with differences in the virulence gene profiles and provided evidence of different lineages for STEC and non-STEC strains. The SNPs discovered in this study can be used to develop tests that will not only accurately identify O26, O45, O103, O111, O121, and O145 strains but also predict whether strains detected in the above-described serogroups contain Shiga toxin-encoding genes.     

Oberonia wynadensis, a new species of Orchidaceae from India

Oberonia wynadensis is described from India. It belongs to the subgenus Oberonia and is related to O. acaulis and O. verticillata in having the flowers arranged in whorls.     

The 4p- syndrome,with a report of two new cases

Summary This report illustrates the typical clinical and cytogenetic findings in two children with the Wolf syndrome (4p- syndrome). The literature of previously published cases is reviewed.

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Zusammenfassung In diesem Bericht werden die typischen klinischen und cytogenetischen Befunde bei zwei Kindern mit Wolf-Syndrom (4p--Syndrom) dargestellt. Bei dieser Gelegen-heit wird eine Übersicht über die bisher publizierten Fälle gegeben.

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Supported by contract No. 20.122 F.W.G.O., Belgium

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Bevoegd Navorser N.F.W.O., Belgium     

Relationships of the Escherichia coli O157, O111, and O55 O-antigen gene clusters with those of Salmonella enterica and Citrobacter freundii, which express identical O antigens

Escherichia coli O157, Salmonella enterica O30, and Citrobacter freundii F90 have identical O-antigen structures, as do E. coli O55 and S. enterica O50. The O-antigen gene cluster sequences for E. coli O157 and E. coli O55 have been published, and the genes necessary for O-antigen biosynthesis have been identified, although transferase genes for glycosidic linkages are only generic and have not been allocated to specific linkages. We determined sequences for S. enterica O30 and C. freundii F90 O-antigen gene clusters and compared them to the sequence of the previously described E. coli O157 cluster. We also determined the sequence of the S. enterica O50 O-antigen gene cluster and compared it to the sequence of the previously described E. coli O55 cluster. For both the S. enterica O30-C. freundii F90-E. coli O157 group and the S. enterica O50-E. coli O55 group of O antigens, the gene clusters have identical or nearly identical organizations. The two sets of gene clusters had comparable overall levels of similarity in their genes, which were lower than the levels determined for housekeeping genes for these species, which were 55 to 65% for the genes encoding glycosyltransferases and O-antigen processing proteins and 75 to 93% for the nucleotide-sugar pathway genes. Nonetheless, the similarity of the levels of divergence in the five gene clusters required us to consider the possibility that the parent gene cluster for each structure was in the common ancestor of the species and that divergence is faster than expected for the common ancestor hypothesis. We propose that the identical O-antigen gene clusters originated from a common ancestor, and we discuss some possible explanations for the increased rate of divergence that is seen in these genes.     

Serum T3, T4, FT3, TSH and TBG in Turner's syndrome]

Turner's syndrome was originally reported as sexual infantilism, short stature, webbed neck and cubitus valgus. Subsequent investigations, however, have disclosed many other abnormalities both in chromosomal and physical features occurring in this syndrome. An increased prevalence of Hashimoto's thyroiditis in patients with Turner's syndrome has been well documented and molecular defects of the TBG have been described. In our study we examined serum T3, T4, FT3, FT4, TSH and TBG levels in 18 girls with Turner's syndrome, in 18 healthy control girls and in the parents of both groups. We reported significant elevated levels of T3 and FT3 in the Turner's group (P 0.01). We did not find any quantitative abnormalities of immunoreactive TBG in the same patients.