共查询到20条相似文献,搜索用时 15 毫秒
1.
The aim of the present study was to investigate and compare granule and tablet properties of granules prepared by wet granulation
in a rotary processor or a conventional fluid bed. For this purpose the working range of selected process variables was determined
and a factorial study with 3 factors (equipment type, filler type, and liquid addition rate) and 1 covariate (fluidizing air
flow rate) was performed. Two grades of calcium carbonate with different size and shape characteristics were applied, and
the liquid addition and fluidizing air flow rates were investigated in the widest possible range. Dry mixtures of microcrystalline
cellulose, polyvinyl povidone, calcium carbonate, and riboflavin, in a 10∶5∶84∶1 ratio, were granulated in both types of equipment.
The granulation end point was determined manually in the fluid bed and by torque measurements in the rotary processor. The
filler type had a more pronounced effect on granular properties in the fluid bed, but the rotary processor showed a higher
dependency on the investigated process variables. The rotary processor gave rise to more dense granules with better flow properties,
but the fluid bed granules had slightly better compressional properties. Furthermore, the distribution of a low-dose drug
was found to be more homogeneous in the rotary processor granules and tablets. Generally, wet granulation in a rotary processor
was found to be a good alternative to conventional fluid bed granulation, especially when cohesive powders with poor flow
properties or formulations with low drug content are to be granulated by a fluidizing air technique.
Published: March 10, 2006 相似文献
2.
Mingna Song Ning Li Louwrens R. Tiedt Michael D. Degennaro Melgardt M. de Villiers 《AAPS PharmSciTech》2010,11(2):698-707
The aim of this study was to prepare highly porous carrier particles by emulsion solvent evaporation and compare the loading
capacity of these beads with two traditional carriers, sugar beads, and microcrystalline cellulose granules during an interactive
mixing process. The porous carrier particles were prepared by an emulsion solvent evaporation process using cellulose propionate
as a binder, anhydrous dibasic calcium phosphate, and ion exchange resins as a fillers, and polyethylene glycol as a pore
inducer. Micronized furosemide or griseofulvin powder was mixed with the same volume of each carrier in an interactive mixing
process. The tableting properties, drug loading per unit volume of carrier, content uniformity of the mixtures, and dissolution
of the drugs from the mixtures were measured. The results showed that highly porous microcapsules with desirable hardness
equivalent to that of sugar beads and MCC granules were successfully prepared. On average the loading capacity of the new
carrier was 310% that of sugar beads and 320% that of MCC granules during an interactive mixing process with very good content
uniformity. The tableting properties of the microcapsules were equivalent to that of microcrystalline cellulose granules,
and the dissolution of the drugs from interactive mixtures prepared with the new carrier was equivalent to that of drug suspensions.
This showed that the prepared microcapsule carrier could be used to improve the loading capacity during an interactive mixing
and to prepare tablets by direct compression. 相似文献
3.
Metformin has a poor tabletability and flowability. Therefore, metformin is typically wet granulated with a binder before tableting. To save production costs, it would be desirable to implement a roll compaction/dry granulation (RCDG) process for metformin instead of using wet granulation. In order to implement RCDG, the efficiency of dry binders is crucial to ensure a high drug load and suitable properties of dry granules and tablets. This study evaluates dry granules manufactured by RCDG and subsequently tableting of high metformin content formulations (≥?87.5%). Based on previous results, fine particle grades of hydroxypropylcellulose and copovidone in different fractions were compared as dry binders. The formulations are suitable for RCDG and tableting. Furthermore, results can be connected to in-die and out-of-die compressibility analysis. The addition of 7% of dry binder is a good compromise to generate sufficient mechanical properties on the one hand, but also to save resources and ensure a high metformin content on the other hand. Hydroxypropylcellulose was more efficient in terms of granule size, tensile strength and friability. Three percent croscarmellose was added to reach the specifications of the US Pharmacopeia regarding dissolution. The final formulation has a metformin content of 87.5%. A loss in tabletability does not occur for granules compressed at different specific compaction forces, which displays a robust tensile strength of tablets independent of the granulation process. 相似文献
4.
Kristensen J 《AAPS PharmSciTech》2005,6(3):E495-E503
The aim of the present study was to investigate the use of different grades of microcrystalline cellulose (MCC) and lactose
in a direct pelletization process in a rotary processor. For this purpose, a mixed 2- and 3-level factorial study was performed
to determine the influence of the particle size of microcrystalline cellulose (MCC), (≈60 and 105 μm) and lactose (≈30, 40,
and 55 μm), as well as MCC type (Avicel and Emcocel) on the pelletization process and the physical properties of the prepared
pellets. A 1∶4 mixture of MCC and lactose was applied, and granulation liquid was added until a 0.45 Nm increase in the torque
of the friction plate was reached. All combinations of the 3 factors resulted in spherical pellets of a high physical strength.
The particle size of MCC was found to have no marked effect on the amount of water required for agglomerate growth or on the
size of the resulting pellets. An increasing particle size of lactose gave rise to more spherical pellets of a more narrow
size distribution as well as higher yields. The MCC type was found to affect both the release of the model drug from the prepared
pellets and the size distribution. Generally, the determined influence of the investigated factors was small, and direct pelletization
in a rotary processor was found to be a robust process, insensitive to variations in the particle size and type of MCC and
the particle size of lactose.
Published: October 24, 2005 相似文献
5.
The objective of this study was to investigate the properties of granules and tablets with carbamazepine which were prepared
employing a fluidized hot-melt granulation (FHMG) technique. The FHMG process was carried out at 65°C. Macrogol 6000 (PEG
6000) was used as a binder at the content 10% (w/w) of the granulated mass. Granules containing up to 70% (w/w) of the drug and 20–90% (w/w) of a filler (lactose, mannitol, calcium hydrogen phosphate (Di-Cafos), pregelatinized starch, and microcrystalline cellulose
(MCC)) were produced. When the drug content was 30% (w/w), the yield of the process was satisfying (>95%) and flowability of the granules was better than placebo granules or drug-loaded
granules prepared by wet granulation. Type of a filler had strong impact on physical properties of granules, and size distribution
of the particles was the most homogenous when lactose or Di-Cafos were used. The FHMG technique enabled preparation of granules
with better compressability compared with the wet-granulated product or with non-granulated powders. Tablets with shorter
disintegration time than 10 min were obtained with 2.0% crospovidone added as a disintegrant. In comparison to tablets prepared
from the wet-granulated mass, employment of the FHMG method resulted in tablets with faster dissolution of carbamazepine (more
than 80% of the drug released within 15 min). This was achieved with mannitol or lactose/MCC, as fillers. 相似文献
6.
The purpose of this research work was to obtain directly compressible agglomerates of ibuprofen with talc by a novel crystallo-co-agglomeration
(CCA) technique, which is an extension of spherical crystallization. Ibuprofen-talc agglomerates were prepared using dichloromethane
(DCM)-water as the crystallization system. DCM acted as a good solvent for ibuprofen as well as a bridging liquid for agglomeration
of crystallized drug with talc. The agglomerates were characterized by differential scanning calorimetry, powder X-ray diffraction,
and scanning electron microscopy and were evaluated for tableting properties and for drug release. The process yielded spherical
agglomerates containing ∼95% to 96% wt/wt of ibuprofen. Agglomerates containing talc showed uniform distribution of hydroxypropylmethylcellulose
and decreased crystallinity, and deformed under pressure. The miniscular form of ibuprofen and the hydrophobicity of talc
governed the drug release rate. The batch containing a higher proportion of talc showed zeroorder kinetics and drug release
was extended up to 13 hours. The CCA technique developed in this study is suitable for obtaining agglomerates of drug with
talc as an excipient. 相似文献
7.
The 3-D model: Comparison of parameters obtained from and by simulating different tableting machines
Picker KM 《AAPS PharmSciTech》2003,4(3):55-61
The aim of this study is to apply 3-D modeling to data obtained from different tableting machines and for different compression
wheels on a linear rotary tableting machine replicator. A new analysis technique to interpret these data by 3-D parameter
plots is presented. Tablets were produced on an instrumented eccentric tableting machine and on a linear rotary tableting
machine replicator. The materials used were dicalcium phosphate dihydrate (DCPD), spray-dried lactose, microcrystalline cellulose
(MCC), hydroxypropyl methylcellulose (HPMC), and theophylline monohydrate. Tableting was performed to different maximum relative
densities (ρ rel, max). Force, time and displacement were recorded during compaction. The 3-D data plots were prepared using pressure, normalized
time, and porosity according to Heckel. A twisted plane was fitted to these data according to the 3-D modeling technique.
The resulting parameters were analyzed in a 3-D parameter plot. The results show that the 3-D modeling technique can be applied
to compaction cycles from different tableting machines as different as eccentric and rotary tableting machines (simulated).
The relation of the data to each other is the same even when the absolute values are different. This is also true for different
compression wheels used on the linear rotary tableting machine replicator. By using compression wheels of different sizes
on this simulator, mainly time plasticity changes. By using bigger compression wheels for simulation, the materials deform
slower at lower densification and they deform faster at higher densification. For brittle materials, the stages of higher
densification are influenced; for plastically deforming materials, the stages of lower and higher densification can be influenced. 相似文献
8.
Picker KM 《AAPS PharmSciTech》2003,4(4):523-530
The objective of this study is to test the hypothesis that time plasticity (parameterd from 3-D modeling) is influenced by tableting speed. Tablets were produced at different maximum relative densities (ϱrel,max) on an instrumented eccentric tableting machine and on a linear rotary tableting machine replicator. Some 3-D data plots
were prepared using pressure, normalized time, and porosity according to Heckel. After fitting of a twisted plane, the resulting
parameters were analyzed in a 3-D parameter plot. The materials used were dicalcium phosphate dihydrate (DCPD), spray-dried
lactose, microcrystalline cellulose (MCC), hydroxypropyl methylcellulose (HPMC), κ-carrageenan (CAR), and theophylline monohydrate
(TheoM). The results show that tableting speed especially influences the parameterd (time plasticity) of the 3-D model for plastically and viscoelastically deforming materials such as MCC, HPMC, CAR, and TheoM.
For more plastically deforming materials such as MCC, HPMC, and TheoM, a subtle influence on ω is also visible. The stages
of higher densification are affected more than the stages of lower densification. Brittle materials such as DCPD exhibit no
influence of tableting speed. The influence of speed on spray-dried lactose is minor. The results are valid for data obtained
from an eccentric tableting machine and also for data from a linear rotary tableting machine replicator. Thus, the empirically
derived parameter time plasticityd really represents the influence of time. 相似文献
9.
The purpose of this research was to obtain directly compressible agglomerates of ibuprofen-paracetamol containing a desired
ratio of drugs using a crystallo-co-agglomeration technique. Crystallo-co-agglomeration is an extension of the spherical crystallization
technique, which enables simultaneous crystallization and agglomeration of 2 or more drugs or crystallization of a drug and
its simultaneous agglomeration with another drug or excipient. Dichloromethane (DCM)-water system containing polyethylene
glycol (PEG) 6000, polyvinyl pyrollidone, and ethylcellulose was used as the crystallization system. DCM acted as a good solvent
for ibuprofen and bridging liquid for agglomeration. The process was performed at pH 5, considering the low solubility of
ibuprofen and the stability of paracetamol. Loss of paracetamol was reduced by maintaining a low process temperature and by
the addition of dextrose as a solubility suppressant. The agglomerates were characterized by differential scanning calorimetry,
powder x-ray diffraction (PXRD), and scanning electron microscopy and were evaluated for tableting properties. The spherical
agglomerates contained an ibuprofen-paracetamol ratio in the range of 1.23 to 1.36. Micromeritic, mechanical, and compressional
properties of the agglomerates were affected by incorporated polymer. The PXRD data showed reduction in intensities owing
to dilution and reduced crystallinity. Thermal data showed interaction between components at higher temperature. Ethylcellulose
imparted mechanical strength to the agglomerates as well as compacts. The agglomerates containing PEG have better comparessibility
but drug release in the initial stages was affected owing to asperity melting, yielding harder compacts. The agglomeration
and properties of agglomerates were influenced by the nature of polymer. 相似文献
10.
Recently, microwave-induced melt granulation was shown to be a promising alternative to conventional melt granulation with
improved process monitoring capabilities. This study aimed to compare the physicochemical and compaction properties of granules
produced from microwave-induced and conventional melt granulation. Powder admixtures comprising equivalent proportions by
weight of lactose 200 M and anhydrous dicalcium phosphate were granulated with polyethylene glycol 3350 under the influence
of microwave-induced and conventional heating in a 10-L single pot high shear processor. The properties of the granules and
compacts produced from the two processes were compared. Relative to conventional melt granulation, the rates at which the
irradiated powders heated up in microwave-induced melt granulation were lower. Agglomerate growth proceeded at a slower rate,
and this necessitated longer massing durations for growth induction. These factors prompted greater evaporative moisture losses
from the melt granules. Additionally, nonuniform heating of the powders under the influence of microwaves led to increased
inter-batch variations in the binder contents of resultant melt granules and a reliance of content homogeneity on massing
duration. Agglomerate growth proceeded more rapidly under the influence of conventional heating due to the enhanced heating
capabilities of the powders. Melt granules produced using the conventional method possessed higher moisture contents and improved
content homogeneity. The compaction behavior of melt granules were affected by their mean sizes, porosities, flow properties,
binder, and moisture contents. The last two factors were responsible for the disparities in compaction behavior of melt granules
produced from microwave-induced and conventional melt granulation. 相似文献
11.
A mathematical model of high shear wet granulation is proposed, where granule breakage, and not growth, is the dominant process.
The energy required for granule breakage is assumed to be provided by the impact of granules between themselves and the granulator
parts, and the extent of granule breakage determined by the balance between the impactenergy and the work of adhesion between
the agglomerating particles. A specific volume of dry powder per unit crack surface area was allowed to reattach to the surface
of broken granules to account for granule growth. To verify proposed model conditions, lactose monohydrate was granulated
with a relatively low amount (6%) of the binder phase, polyvinyl-pyrrolidone and water, and was added to the powder before
granulation.
The trend in granule size distribution during the experiment closely follwed the predicted model with an initial increase
in the weight fraction of the larger granules. This increase was possibly due to extensive breakage of weaker granules and
less extensive breakage, as if by attrition, of stronger granules, accompanied by the attachment of dry powder to the cracked
surfaces. Eventually, larger granules experience increased impact energy and break. When excess binder is added and, higher
volumes of powder reattach to the crack surface, more large granules form leading to granule overgrowth. This model highlights
the importance of the probability of impact per unit time interval (ie, the rate of impact), the strength of the granules
and the volume of powder that could attach to the cracked surface in high shear granulation processes where significant granule
breakage is encountered.
Published: August 10, 2007 相似文献
12.
The crystallo-co-agglomeration technique was used to design directly compressible and deformable agglomerates of talc containing the low-dose drug bromhexine hydrochloride (BXH). The process of agglomeration involved the use of dichloromethane as a good solvent and bridging liquid for BXH, water as a poor solvent, talc as diluent, and Tween 80 to aid dispersion of BXH and diluent into the poor solvent. Hydroxypropyl methylcellulose (50 cps) 4% wt/wt was used to impart the desired mechanical strength and polyethylene glycol 6000 5% wt/wt was used to impart the desired sphericity to the agglomerates. Clarity of the supernatant was considered an endpoint for completion of the agglomeration process. The drug-to-talc ratio in optimized batch 1 (BT1) and batch 2 (BT2) was kept at 1:15.66 and 1:24, respectively. The spherical agglomerates obtained were evaluated for topographic, micromeritic, mechanical, deformation, compressional, and drug release properties. The agglomeration yield and drug entrapment for both batches were above 94% wt/wt. Crushing strength and friability studies showed good handling qualities of agglomerates. Heckel plot studies showed low mean yield pressure and high tensile strength, indicating excellent compressibility and compactibility of agglomerates. Diametral and axial fracture of compacts showed deformation of agglomerates revealing formation of a heterogeneous compact. Drug release was sustained for 9 hours and 5 hours from BT1 and BT2, respectively, in 0.1N HCl. Hence, the crystallo-co-agglomeration technique can be successfully used for obtaining spherical, deformable, and directly compressible agglomerates, generating a heterogeneous matrix system and providing sustained drug release. 相似文献
13.
The crystallo-co-agglomeration technique was used to design directly compressible and deformable agglomerates of talc containing
the low-dose drug bromhexine hydrochloride (BXH). The process of agglomeration involved the use of dichloromethane as a good
solvent and bridging liquid for BXH, water as a poor solvent, talc as diluent, and Tween 80 to aid dispersion of BXH and diluent
into the poor solvent. Hydroxypropyl methylcellulose (50 cps) 4% wt/wt was used to impart the desired mechanical strength
and polyethylene glycol 6000 5% wt/wt was used to impart the desired sphericity to the agglomerates. Clarity of the supernatant
was considered an endpoint for completion of the agglomeration process. The drug-to-talc ratio in optimized batch 1 (BT1)
and batch 2 (BT2) was kept at 1:15.66 and 1:24, respectively. The spherical agglomerates obtained were evaluated for topographic,
micromeritic, mechanical, deformation, compressional, and drug release properties. The agglomeration yield and drug entrapment
for both batches were above 94% wt/wt. Crushing strength and friability studies showed good handling qualities of agglomerates.
Heckel plot studies showed low mean yield pressure and high tensile strength, indicating excellent compressibility and compactibility
of agglomerates. Diametral and axial fracture of compacts showed deformation of agglomerates revealing formation of a heterogeneous
compact. Drug release was sustained for 9 hours and 5 hours from BT1 and BT2, respectively, in 0.1N HCl. Hence, the crystallo-co-agglomeration
technique can be successfully used for obtaining spherical, deformable, and directly compressible agglomerates, generating
a heterogeneous matrix system and providing sustained drug release.
Published: July 27, 2007 相似文献
14.
以填充剂种类、辅料配比、原料用量、干燥温度和黏合剂用量为考察因素,以颗粒合格率、溶化性、吸湿性和感官评价的总评归一值(OD)作为评价指标,采用单因素实验并结合响应面优化设计优选金线莲颗粒剂最佳成型工艺。结果表明,最佳成型工艺为辅料乳糖:糊精=3:1,原料药比例7.01%、干燥温度50 ℃,按此方案进行试验,预测颗粒成型率87.18%,吸湿率8.22%,溶化时间34.95 s,感官评价81分。采用响应面法优化金线莲颗粒的成型工艺结果可靠,可为金线莲颗粒剂的工业化生产提供依据。 相似文献
15.
Densification of switchgrass into consistent and high-density solid feedstock will reduce the cost of transport, handling, and storage to produce fuels and chemicals. Development a novel, low-cost densification technology is critical for reducing the delivered cost of feedstock while improving the bulk flow properties of densified products. In this paper, a novel wet granulation technology was proposed to investigate the effect of lime pretreatment on the production of switchgrass granules. Granulation is a process of agglomerating fine powders by wetting powder surfaces with liquid binders and mild application of shear/vibrating forces. Switchgrass was size reduced into fine powders using a knife mill and pretreated with three lime loading rates (0.05, 0.1, 0.2 g/g of biomass) at 121 °C for 30 min and at room temperature (25 °C) for 72 h. The structural modification of pretreated samples was analyzed by scanning electron microscopy and autofluorescence microscopy. Pretreated samples were granulated using a pan granulator with pre-formulated starch binder. Granules made from 20 % (0.2 g/g of biomass) lime loading rate had significantly higher single granule density and angle of repose with lower binder requirement than that of untreated granules. Lime treatment did not significantly increase the bulk density and hardness of granules. Lime-treated granules had significantly higher ash content and lower gross calorific value than that of untreated granules. In overall, lime treatment was not attractive to produce granules for thermochemical conversion platform, but lime-treated granules could be used to produce liquid biofuels and platform chemicals in biochemical conversion platform. 相似文献
16.
Graham R Stirling Linda J Smith Kerrie A Licastro Lois M Eden 《Biological Control》1998,11(3):224-230
Arthrobotrys dactyloidesgrew readily in shaken flasks containing glucose corn steep powder and 8–10 g dry wt of fungal biomass/liter medium was usually produced in 5–6 days. However, it was difficult to convert this biomass into a viable, granulated product suitable for commercial use in biological control. Formulations prepared using kaolin and vermiculite as carriers and gum arabic as a binder showed poor viability when biomass was harvested from liquid culture, mixed with formulation ingredients, granulated, and then dried to a moisture content of less than 5%. Inclusion of a solid-phase incubation step following granulation and prior to drying (incubation of moist granules for 3 days at 25°C in a sterile plastic bag aerated with sterile air) markedly improved biological activity. When granules produced in this manner were placed on a glass slide in field soil, hyphae proliferated from granules and always produced traps. Seven experiments in soil microcosms showed that formulations which had been subjected to solid phase incubation prior to drying consistently reduced numbers ofMeloidogyne javanicajuveniles by more than 90%. In seven glasshouse experiments in which field soils were treated with granules (10 g/liter) and planted to tomatoes, the number of galls induced by the nematode was reduced by 57–96%. 相似文献
17.
为了解决黑果枸杞中花青素稳定性问题,本文采用Box-Behnken设计对黑果枸杞提取物泡腾片配方进行优化,并对其进行质量评价。采用酸碱混合制粒压片法,通过单因素实验,筛选出片剂所需的辅料:崩解剂、填充剂、润滑剂以及甜味剂。采用响应面试验,结合感官评价进行处方优化,从而确定最优配方:柠檬酸32%、黑果枸杞提取物25%、碳酸氢钠24%、乳糖15%、甜蜜素3%、聚乙二醇6000 1%;对最优配方进行质量评价,各项指标均符合规定,其中花青素含量为8.06 mg/g。该泡腾片表面光滑,泡腾效果好,具有黑果枸杞香气,为实际生产提供理论依据。 相似文献
18.
There is a growing interest for multiparticulate solid dosage forms such as pellets, because of their several advantages over tablets during drug therapy. It is essential to investigate the drug dissolution process which can be influenced by the composition and manufacturing process technology, too. This study was performed applying experimental design in order to evaluate the effects of independent process variables during high-shear pelletisation, taking the impeller speed (x1) and granulation binder flow rate (x2) as factors into consideration. Theophylline containing pellet formulation was prepared using a matrix consisted of ethylcellulose, microcrystalline cellulose and lactose. Dissolution profiles were modeled by the Weibull function to evaluate the power of process variables. Both process variables were powerful to influence the particle agglomeration. A linear regression was found between the particle size and the diffuse reflectance values after the Kubelka-Munk transformation. Differences in the diffuse reflectance spectra of pellet samples related to particle size offer a fast instrumental method for the in-process control. 相似文献
19.
The effect of anhydrous lactose particle size distribution on its performance in the wet granulation process was evaluated.
Three grades of anhydrous lactose were used in the study: “as is” manufacturer grade and 2 particle size fractions obtained
by screening of the 60M lactose. Particle growth behavior of the 3 lactose grades was evaluated in a high shear mixer. Compactibility
and porosity of the resulting granules were also evaluated. A uniaxial compression test on moist agglomerates of the 3 lactose
grades was performed in an attempt to explain the mechanism of particle size effect observed in the high shear mixer. Particle
growth of anhydrous lactose in the high shear mixer was inversely related to the particle size of the starting material. In
addition, granulation manufactured using the grade with the smallest particle size was more porous and demonstrated enhanced
compactibility compared with the other grades. Compacts with similar porosity and low liquid saturation demonstrated brittle
behavior and their breakage strength was inversely related to lactose particle size in the uniaxial compression test, suggesting
that material with smaller particle size may exhibit more pronounced nucleation behavior during wet granulation. On the other
hand, compacts prepared at higher liquid saturation and similar compression force exhibited more plastic behavior and showed
lower yield stress for the grade with smallest particle size. The lower yield stress of compacts prepared with this grade
may indicate a higher coalescence tendency for its granules during wet granulation. 相似文献
20.
The aim of the study was to analyze hydroxypropylcellulose (HPC) in pure form and in excipient mixtures and to relate its physical and chemical properties to tablet binder functionality. The materials used were Klucel hydroxypropylcellulose grades ranging from low to high molecular weight (80-1000 kDa) of regular particle size (250 microm mean size) and fine particle size (80 microm mean size). These were compared with microcrystalline cellulose, spray-dried lactose, and dicalcium phosphate dihydrate. Thermal behavior of HPC was analyzed by modulated temperature differential scanning calorimetry (MTDSC). Tablets of the pure materials and of dry blends with 4% low viscosity, fine particle HPC and 30% high viscosity, fine particle HPC were produced on an instrumented eccentric tableting machine at 3 relative humidities. The 3-dimensional (3-D) model with the parameters time plasticity d, pressure plasticity e, and the twisting angle omega, the inverse of fast elastic decompression was compared with the Heckel method for characterization of compaction. Elastic recovery and compactibility were also studied. The results show that HPC tablet formation is characterized by high plastic deformation. The d, e, and omega values were markedly higher as compared with the reference materials. Plasticity was highest for the fine particle size HPC types. Maximum compactibility was observed for low molecular weight, fine particle size HPC. Tableting of the mixtures showed deformation, which was strongly influenced by HPC. Plasticity and crushing force of formed tablets was increased. In conclusion, HPC is characterized by strong plastic deformation properties, which are molecular weight and particle size dependent. 相似文献