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Fleming A  Osley MA 《Cell》2004,119(4):449-451
Two recent papers (de Napoles et al., 2004 and Wang et al., 2004) have linked monoubiquitylation of histone H2A to the activities of E3 ubiquitin ligases that reside in Polycomb-group repressor complexes.  相似文献   

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Silence in the germ   总被引:1,自引:0,他引:1  
Pirrotta V 《Cell》2002,110(6):661-664
Gene expression in C. elegans germline cells is subject to strict controls. A set of MES proteins, including SET domain proteins and two homologs of Polycomb group proteins, establish an epigenetically transmitted silenced state that affects X chromosome gene expression.  相似文献   

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A large fraction of genes in the mammalian genome is repressed in every cell throughout development. Here, we propose that this long-term silencing is carried out by distinct molecular mechanisms that operate in a global manner and, once established, can be maintained autonomously through DNA replication. Both individually and in combination these mechanisms bring about repression, mainly by lowering gene accessibility through closed chromatin structures.  相似文献   

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植物转基因沉默研究进展   总被引:2,自引:0,他引:2  
植物基因沉默现象是转基因植物在广泛应用中遇到的一个重要障碍.主要就引起植物转基因沉默因素、相应对策以及研究意义作一综述.  相似文献   

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Silence of the strands: RNA interference in eukaryotic pathogens   总被引:14,自引:0,他引:14  
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Silence sets on a sensory map   总被引:1,自引:0,他引:1  
Bennett MK  Reed RR 《Neuron》2004,42(4):521-522
Recent efforts to understand the contribution of neuronal activity in the creation of the olfactory sensory map have focused on odor-evoked events. In this issue of Neuron, Yu et al. discover a new role for neuronal activity in the organization and maintenance of the olfactory system. Their results highlight the role of spontaneous activity and synaptic transmission in axon outgrowth and olfactory neuron survival.  相似文献   

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A new interpretation of L.S. Vygotsky's “The Tragedy of Hamlet, the Prince of Denmark” and his little-known publication “Traurnye stroki-Den' 9 ava.” An essential question (object) of these texts is the secret of genuine human overcoming of suffering. This is also the main problem of psychotherapy. Vygotsky's answer has both psychological and religious sgnificance: the experience of a tragedy is mediated by prayer. Vygotsky's idea creates the basis for religiously oriented, “synergetic” psychotherapy where the main process will be spiritual, including prayer.  相似文献   

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piRNA是单链非编码小分子RNA,长度约26-31nt,大部分集中在29-30nt,5’端具有尿嘧啶偏向性(约86%),能够与Argonaute蛋白家族中的Piwi亚家族蛋白相互结合而产生作用。piRNA的功能主要是维持基因组中转座子的正常沉默状态,以防止基因组中转座子爆发而引起相应基因的改变。piRNA与siRNA及miRNA均是近些年发现的非编码小RNA,它们均可通过一套相应的机制进行RNA干扰,在转录、转录后甚至翻译水平对靶基因及蛋白进行调节,它们之间既有联系又有区别。piRNA数据库的建立将对这类小分子RNA的研究有很大的促进作用。  相似文献   

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转基因植物中外源基因的沉默及应对策略   总被引:1,自引:0,他引:1  
随着转基因技术在作物育种领域的应用,转基因植物中外源基因表达量低的现象较为普遍。导致外源基因表达量低的主要原因是基因沉默。外源基因沉默可分为转录水平的基因沉默和转录后水平的基因沉默。如何应对基因沉默,提高外源基因的表达量,是转基因技术发展亟待解决的问题。  相似文献   

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Philip C. Parnell 《Ethnos》2013,78(4):453-469
Western law constructs the individual as an agent who can assume responsibility for action independently of context, thus creating an accessible place for hiding systemic political violence. This article considers how individual surrogates of political violence who silence the messages of a Oaxacan assassination emerge from reflexivity as a self-discipline that creates individual agency, law's notion of individual responsibility, and the personalizing processes of bodily violence. Thirty-two years after the assassination, its ethnographer confronts unwelcome knowledge revealed when the silence is broken. Reexamination of his own experiences the night of the murder uncovers ideological levers through which those who become the ‘individuals’ of events are led to detach their behaviors from experience to accept legal constructions of societal relationships.  相似文献   

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